Genular: Defining Cellular Identity and Function

Details for: Phb1

Gene ID: 18673

Symbol: Phb1

Ensembl ID: ENSMUSG00000038845

Description: prohibitin 1

Associated with

Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Mitochondrial calcium ion transport
(R-MMU-8949215)
Processing of smdt1
(R-MMU-8949664)
Raf/map kinase cascade
(R-MMU-5673001)
Raf activation
(R-MMU-5673000)
Signal transduction
(R-MMU-162582)
Transport of small molecules
(R-MMU-382551)
Activation of phospholipase c activity
(GO:0007202)
Activation of protein kinase c activity
(GO:1990051)
Antiviral innate immune response
(GO:0140374)
B cell activation
(GO:0042113)
Cd40 signaling pathway
(GO:0023035)
Cell surface
(GO:0009986)
Cellular response to interleukin-6
(GO:0071354)
Complement component c3a binding
(GO:0001850)
Complement component c3b binding
(GO:0001851)
Cytoplasm
(GO:0005737)
Dna biosynthetic process
(GO:0071897)
Early endosome
(GO:0005769)
Enzyme binding
(GO:0019899)
Epigenetic regulation of gene expression
(GO:0040029)
Extrinsic component of presynaptic active zone membrane
(GO:0098891)
Gaba-ergic synapse
(GO:0098982)
Glutamatergic synapse
(GO:0098978)
Histone deacetylase binding
(GO:0042826)
Membrane
(GO:0016020)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrial prohibitin complex
(GO:0035632)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Modulation by host of viral rna genome replication
(GO:0044830)
Myelin sheath
(GO:0043209)
Negative regulation of androgen receptor signaling pathway
(GO:0060766)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of glucocorticoid receptor signaling pathway
(GO:2000323)
Negative regulation of protein catabolic process
(GO:0042177)
Negative regulation of transcription by competitive promoter binding
(GO:0010944)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of complement activation
(GO:0045917)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of g protein-coupled receptor signaling pathway
(GO:0045745)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Postsynaptic density
(GO:0014069)
Progesterone receptor signaling pathway
(GO:0050847)
Proteinase activated receptor binding
(GO:0031871)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein stabilization
(GO:0050821)
Regulation of dna-templated transcription
(GO:0006355)
Rig-i signaling pathway
(GO:0039529)
Symbiont entry into host cell
(GO:0046718)
Synapse
(GO:0045202)
T-helper 17 type immune response
(GO:0072538)
Transcription corepressor activity
(GO:0003714)

Other Information

Proteins

B-cell receptor-associated protein 32

Genular Protein ID: 4051172953

Symbol: PHB1_MOUSE

Name: B-cell receptor-associated protein 32

UniProtKB Accession Codes:

P67778 P24142 Q3UB75 Q5SQG4

Database IDs:

Citations:

PubMed ID: 8070406

Title: The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein.

PubMed ID: 8070406

DOI: 10.1002/j.1460-2075.1994.tb06689.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11302691

Title: Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence.

PubMed ID: 11302691

DOI: 10.1006/excr.2001.5166

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20959514

Title: Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.

PubMed ID: 20959514

DOI: 10.1096/fj.10-167502

PubMed ID: 23241883

Title: Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes.

PubMed ID: 23241883

DOI: 10.4049/jimmunol.1201646

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

PubMed ID: 24856930

Title: DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.

PubMed ID: 24856930

DOI: 10.1016/j.cmet.2014.04.016

PubMed ID: 24947361

Title: Prohibitin overexpression in adipocytes induces mitochondrial biogenesis, leads to obesity development, and affects glucose homeostasis in a sex-specific manner.

PubMed ID: 24947361

DOI: 10.2337/db13-1807

PubMed ID: 29324904

Title: Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis.

PubMed ID: 29324904

DOI: 10.1371/journal.ppat.1006778

PubMed ID: 31819158

Title: Prohibitin levels regulate OMA1 activity and turnover in neurons.

PubMed ID: 31819158

DOI: 10.1038/s41418-019-0469-4

Sequence Information:

Length: 272
Mass: 29820
Checksum: 6B26073E169C2FFC
Sequence:

MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV GEGTHFLIPW 
VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA SQLPRIYTSI GEDYDERVLP 
SITTEILKSV VARFDAGELI TQRELVSRQV SDDLTERAAT FGLILDDVSL THLTFGKEFT 
EAVEAKQVAQ QEAERARFVV EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK 
LEAAEDIAYQ LSRSRNITYL PAGQSVLLQL PQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Phb1

Associated with

Other Information

The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. PubMed ID: 8070406

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. PubMed ID: 11302691

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. PubMed ID: 20959514

Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes. PubMed ID: 23241883

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753

DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling. PubMed ID: 24856930

Prohibitin overexpression in adipocytes induces mitochondrial biogenesis, leads to obesity development, and affects glucose homeostasis in a sex-specific manner. PubMed ID: 24947361

Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis. PubMed ID: 29324904

Prohibitin levels regulate OMA1 activity and turnover in neurons. PubMed ID: 31819158