Genular: Defining Cellular Identity and Function

Details for: Phf2

Gene ID: 18676

Symbol: Phf2

Ensembl ID: ENSMUSG00000038025

Description: PHD finger protein 2

Associated with

Chromatin modifying enzymes
(R-MMU-3247509)
Hdms demethylate histones
(R-MMU-3214842)
Chromatin organization
(GO:0006325)
Chromosome
(GO:0005694)
Chromosome, centromeric region
(GO:0000775)
Dioxygenase activity
(GO:0051213)
Histone demethylase activity
(GO:0032452)
Histone h3k9 demethylase activity
(GO:0032454)
Histone h4k20 demethylase activity
(GO:0035575)
Iron ion binding
(GO:0005506)
Kinetochore
(GO:0000776)
Metal ion binding
(GO:0046872)
Methylated histone binding
(GO:0035064)
Negative regulation of rdna heterochromatin formation
(GO:0061188)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oxidoreductase activity
(GO:0016491)
Protein binding
(GO:0005515)
Protein demethylation
(GO:0006482)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator activity
(GO:0003712)
Transcription initiation-coupled chromatin remodeling
(GO:0045815)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Lysine-specific demethylase PHF2

Genular Protein ID: 3159428419

Symbol: PHF2_MOUSE

Name: Lysine-specific demethylase PHF2

UniProtKB Accession Codes:

Q9WTU0 Q6A023 Q80WA8

Database IDs:

Citations:

PubMed ID: 10051327

Title: PHF2, a novel PHD finger gene located on human chromosome 9q22.

PubMed ID: 10051327

DOI: 10.1007/s003359900989

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15368895

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 15368895

DOI: 10.1093/dnares/11.3.205

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20129925

Title: Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation.

PubMed ID: 20129925

DOI: 10.1074/jbc.c109.097667

PubMed ID: 22921934

Title: Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20.

PubMed ID: 22921934

DOI: 10.1016/j.molcel.2012.07.020

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

Sequence Information:

Length: 1096
Mass: 120814
Checksum: 778B822C007D8860
Sequence:

MATVPVYCVC RLPYDVTRFM IECDACKDWF HGSCVGVEEE EAPDIDIYHC PNCEKTHGKS 
TLKKKRTWHK HGPGPTPDVK PVQNGSQLFI KELRSRTFPS AEDVVSRVPG SQLTVGYMEE 
HGFTEPILVP KKDGLGLAVP APTFYVSDVE NYVGPERSVD VTDVTKQKDC KMKLKEFVDY 
YYSTNRKRVL NVTNLEFSDT RMSSFVEPPD IVKKLSWVEN YWPDDALLAK PKVTKYCLIC 
VKDSYTDFHI DSGGASAWYH VLKGEKIFYL IRPASANISL YERWRSASNH SEMFFADQVD 
RCYKCTVKQG QTLFIPSGWI YATLTPVDCL AFAGHFLHSL SVEMQMRAYE VERRLKLGSL 
TQFPNFETAC WYMGKHLLEA FKGSHKSGKQ LPPHLVQGAK ILNGAFRSWT KKQALAEHED 
ELPEHFRPSQ LIKDLAKEIR LSENASKTVR PEVNAAASSD EVCDGDREKE EPPSPVETTP 
PRSLLEKVSK KKTSKTVKMP KPSKIPKPPK SPKPPKTLKL KDGSKKKGKK CKESASPTIP 
NLDLLEAHTK EALTKMEPPK KGKTPKSVLS VPNKDTVHTQ NDMERLEIRE QTKSKSEAKW 
KYKNSKPDSL LKMEEEQRLE KSPLAGNKDK FSFSFSNRKL LGSKALRPPS SPGVFGALQS 
FKEDKAKPVR DEYEYVSDDG ELKIDEFPIR RKKSAPKRDL SFLLDKKEAL LMPTSKPKLD 
SAVYKSDDSS DEGSLHIDTD TKPGRNAKVK KESGSSAAGI LDLLQASEEV GALEYNPNSQ 
PPASPSTQEA IQGMLSMANL QASDSCLQTT WGTGQAKGGS LAAHGARKIG GGNKGTGKRL 
LKRTAKNSVD LEDYEEQDHL DACFKDSDYV YPSLESDEDN PVFKSRSKKR KGSDDAPYSP 
TARVGPSVPR QDRPVREGTR VASIETGLAA AAAKLSQQEE QKNRKKKNTK RKPAPNTASP 
SISTSASAST GTTSASTTPA STTPASTTPA STTPASTSTA SSQASQEGSS PEPPPESHSS 
SLADHEYTAA GTFSGSQAGR ASQPMAPGVF LTQRRPSASS PNNTAAKGKR TKKGMATAKQ 
RLGKILKIHR NGKLLL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Phf2

Associated with

Other Information

PHF2, a novel PHD finger gene located on human chromosome 9q22. PubMed ID: 10051327

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. PubMed ID: 15368895

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. PubMed ID: 20129925

Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. PubMed ID: 22921934

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337