Details for: APLNR

Gene ID: 187

Symbol: APLNR

Ensembl ID: ENSG00000134817

Description: apelin receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 5.4146
    Cell Significance Index: 20.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.7833
    Cell Significance Index: 31.6200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.5183
    Cell Significance Index: 23.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7204
    Cell Significance Index: 12.7300
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.6862
    Cell Significance Index: 5.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4017
    Cell Significance Index: 84.6100
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.2875
    Cell Significance Index: 1.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.1843
    Cell Significance Index: 103.9600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1754
    Cell Significance Index: 1.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0715
    Cell Significance Index: 44.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0029
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0000
    Cell Significance Index: 0.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0013
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0071
    Cell Significance Index: -1.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0137
    Cell Significance Index: -4.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0145
    Cell Significance Index: -7.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0200
    Cell Significance Index: -2.2800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0202
    Cell Significance Index: -0.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0207
    Cell Significance Index: -2.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0212
    Cell Significance Index: -6.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0216
    Cell Significance Index: -9.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0328
    Cell Significance Index: -5.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0335
    Cell Significance Index: -6.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0432
    Cell Significance Index: -4.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0487
    Cell Significance Index: -5.9900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0501
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0534
    Cell Significance Index: -6.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0552
    Cell Significance Index: -7.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0560
    Cell Significance Index: -1.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0573
    Cell Significance Index: -7.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0598
    Cell Significance Index: -3.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0627
    Cell Significance Index: -4.8200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0837
    Cell Significance Index: -1.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0863
    Cell Significance Index: -5.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0971
    Cell Significance Index: -7.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0994
    Cell Significance Index: -6.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1002
    Cell Significance Index: -6.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1094
    Cell Significance Index: -4.4800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1106
    Cell Significance Index: -1.8600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1121
    Cell Significance Index: -1.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1246
    Cell Significance Index: -3.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1249
    Cell Significance Index: -2.0900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1262
    Cell Significance Index: -1.6300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1283
    Cell Significance Index: -1.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1396
    Cell Significance Index: -6.5600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1432
    Cell Significance Index: -1.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1488
    Cell Significance Index: -7.8100
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.1573
    Cell Significance Index: -1.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1582
    Cell Significance Index: -6.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1616
    Cell Significance Index: -9.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1656
    Cell Significance Index: -8.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1677
    Cell Significance Index: -7.8200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1692
    Cell Significance Index: -4.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1708
    Cell Significance Index: -5.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1715
    Cell Significance Index: -5.9600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1754
    Cell Significance Index: -4.3800
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.1803
    Cell Significance Index: -2.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1815
    Cell Significance Index: -3.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1873
    Cell Significance Index: -5.0100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1874
    Cell Significance Index: -3.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1886
    Cell Significance Index: -5.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1931
    Cell Significance Index: -8.5400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2079
    Cell Significance Index: -2.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2092
    Cell Significance Index: -6.8500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2094
    Cell Significance Index: -4.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2129
    Cell Significance Index: -6.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2141
    Cell Significance Index: -6.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2263
    Cell Significance Index: -8.5700
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: -0.2302
    Cell Significance Index: -0.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2367
    Cell Significance Index: -6.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2480
    Cell Significance Index: -7.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2498
    Cell Significance Index: -9.1700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2512
    Cell Significance Index: -5.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2693
    Cell Significance Index: -7.0800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2709
    Cell Significance Index: -3.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2746
    Cell Significance Index: -6.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2799
    Cell Significance Index: -7.1300
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2817
    Cell Significance Index: -3.0600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2823
    Cell Significance Index: -7.0500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2888
    Cell Significance Index: -2.2800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2896
    Cell Significance Index: -4.1200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.2913
    Cell Significance Index: -1.7200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.3103
    Cell Significance Index: -2.9500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3206
    Cell Significance Index: -6.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3217
    Cell Significance Index: -6.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3241
    Cell Significance Index: -3.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3259
    Cell Significance Index: -8.8700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3313
    Cell Significance Index: -6.9200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3336
    Cell Significance Index: -4.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3361
    Cell Significance Index: -8.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3370
    Cell Significance Index: -7.3800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3385
    Cell Significance Index: -6.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3402
    Cell Significance Index: -7.2200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3457
    Cell Significance Index: -5.9100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3476
    Cell Significance Index: -4.0000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3486
    Cell Significance Index: -3.9600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3530
    Cell Significance Index: -4.0400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3532
    Cell Significance Index: -3.8400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.3556
    Cell Significance Index: -5.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression in Endothelial Cells**: The Apelin receptor is significantly expressed in endothelial cells of sinusoids, cardiac endothelial cells, and mural cells, indicating its role in vascular development and maintenance. 2. **G Protein-Coupled Receptor Activity**: The Apelin receptor belongs to the class A/1 rhodopsin-like receptors, which are characterized by their ability to activate G protein-coupled signaling pathways. 3. **Positive Regulation of Angiogenesis**: The Apelin receptor promotes angiogenesis, the formation of new blood vessels, by stimulating the proliferation and migration of endothelial cells. 4. **Negative Regulation of Camp-Mediated Signaling**: The Apelin receptor also negatively regulates camp-mediated signaling, which is involved in various cellular processes, including cell growth and differentiation. **Pathways and Functions:** 1. **Adult Heart Development**: The Apelin receptor is involved in heart development, including atrioventricular valve formation and ventricular septum morphogenesis. 2. **Angiogenesis**: The Apelin receptor promotes angiogenesis by stimulating the release of sequestered calcium ions into the cytosol and activating vascular associated smooth muscle cell differentiation. 3. **Vasculature Development**: The Apelin receptor is essential for vasculature development, including coronary vasculature formation and venous blood vessel development. 4. **Regulation of Body Fluid Levels**: The Apelin receptor plays a role in regulating body fluid levels by influencing the activity of the renin-angiotensin system. **Clinical Significance:** 1. **Cardiovascular Diseases**: Dysregulation of the Apelin receptor has been implicated in various cardiovascular diseases, including hypertension, heart failure, and atherosclerosis. 2. **Angiogenesis-related Disorders**: The Apelin receptor's role in angiogenesis makes it a potential target for the treatment of angiogenesis-related disorders, such as cancer and inflammatory diseases. 3. **Regulation of Body Fluid Levels**: The Apelin receptor's involvement in regulating body fluid levels suggests its potential as a therapeutic target for disorders related to fluid balance, such as edema and dehydration. In conclusion, the Apelin receptor plays a critical role in cardiovascular development, angiogenesis, and regulation of body fluid levels. Its dysregulation has been implicated in various cardiovascular diseases, making it an attractive target for therapeutic interventions. Further research is needed to fully understand the mechanisms of the Apelin receptor and its role in human disease.

Genular Protein ID: 2653762008

Symbol: APJ_HUMAN

Name: Apelin receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8294032

Title: A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11.

PubMed ID: 8294032

DOI: 10.1016/0378-1119(93)90495-o

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11090199

Title: Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry.

PubMed ID: 11090199

DOI: 10.1128/jvi.74.24.11972-11976.2000

PubMed ID: 25639753

Title: Elabela-apelin receptor signaling pathway is functional in mammalian systems.

PubMed ID: 25639753

DOI: 10.1038/srep08170

PubMed ID: 28137936

Title: Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension.

PubMed ID: 28137936

DOI: 10.1161/circulationaha.116.023218

Sequence Information:

  • Length: 380
  • Mass: 42660
  • Checksum: 78DB18BEA6D2B2E4
  • Sequence:
  • MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK 
    RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL 
    TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ 
    CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL 
    RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV 
    NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK 
    GGEQMHEKSI PYSQETLVVD

Genular Protein ID: 412901375

Symbol: B2RDH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 380
  • Mass: 42790
  • Checksum: 53B6AB649B7161A9
  • Sequence:
  • MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK 
    RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL 
    TGLSFDRYLA IVRPVANARL RLRVSWAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ 
    CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL 
    RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV 
    NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK 
    GGEQMHEKSI PYSQETLVVD

Genular Protein ID: 1878646929

Symbol: B3KQN4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 380
  • Mass: 42689
  • Checksum: 78D9CA6EA6D2B1E7
  • Sequence:
  • MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK 
    RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL 
    TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ 
    CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL 
    RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV 
    NSCLNPFLYA FFDPRFRRAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK 
    GGEQMHEKSI PYSQETLVVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.