Details for: APLNR

Gene ID: 187

Symbol: APLNR

Ensembl ID: ENSG00000134817

Description: apelin receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.54
    Marker Score: 373
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.51
    Marker Score: 2864
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169563
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.3
    Marker Score: 303
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7632
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.08
    Marker Score: 1019
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.94
    Marker Score: 210
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.82
    Marker Score: 1670
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.67
    Marker Score: 322
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 416
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 465
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.54
    Marker Score: 359
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.54
    Marker Score: 8450
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.51
    Marker Score: 865
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.5
    Marker Score: 285
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.49
    Marker Score: 2962
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.49
    Marker Score: 442
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 128
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.48
    Marker Score: 956
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.46
    Marker Score: 117
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 434
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 389
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 183
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.42
    Marker Score: 116
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.41
    Marker Score: 602
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.41
    Marker Score: 1036
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.4
    Marker Score: 344
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.37
    Marker Score: 244
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.36
    Marker Score: 219
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.35
    Marker Score: 375
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 313
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.29
    Marker Score: 77
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.28
    Marker Score: 72
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.27
    Marker Score: 113
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.27
    Marker Score: 84.5
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.26
    Marker Score: 5475
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 113
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.25
    Marker Score: 57
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.23
    Marker Score: 231
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.22
    Marker Score: 83
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.22
    Marker Score: 88
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2
    Marker Score: 83.5
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.19
    Marker Score: 45
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.19
    Marker Score: 576
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 102
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.17
    Marker Score: 106
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.17
    Marker Score: 145
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.14
    Marker Score: 59
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.13
    Marker Score: 131
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.13
    Marker Score: 203
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.12
    Marker Score: 149
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.12
    Marker Score: 61
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 69.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.12
    Marker Score: 117
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.12
    Marker Score: 112
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.11
    Marker Score: 67
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.11
    Marker Score: 113
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.11
    Marker Score: 23
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.11
    Marker Score: 71
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.1
    Marker Score: 428
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.1
    Marker Score: 70
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1
    Marker Score: 834
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.09
    Marker Score: 44
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.09
    Marker Score: 101
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.08
    Marker Score: 58
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 143
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.08
    Marker Score: 252
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.08
    Marker Score: 81
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.08
    Marker Score: 15
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.07
    Marker Score: 57

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Other Information

**Key characteristics:** * APLR is a member of the G protein-coupled receptor (GPCR) family of cell surface receptors. * It is a type a/1 GPCR, which are characterized by the presence of a single transmembrane domain that is homologous to the extracellular domain of rhodopsin. * APLR is expressed on the surface of endothelial cells, where it is involved in the regulation of blood flow. * It is also expressed on the surface of cardiac cells, where it is involved in the regulation of cardiac function. * APLR is also expressed on the surface of mural cells, where it is involved in the formation of blood vessels. * It is also expressed on the surface of immune cells, where it is involved in the regulation of inflammation and immune responses. **Pathways and functions:** * APLR is a key regulator of angiogenesis. It is expressed in high levels in endothelial cells, where it is involved in the formation of new blood vessels. * APLR is also expressed in cardiac cells, where it is involved in the regulation of cardiac function. * It is involved in the development and maintenance of the cardiovascular endothelium. * APLR is also involved in the development of the endocardial cushion, a layer of cells that lines the heart and blood vessels. * It is involved in the regulation of blood vessel development. **Clinical significance:** APLR is a potential therapeutic target for a variety of diseases. For example, mutations in the APLR gene have been linked to a number of cardiovascular diseases, including heart failure, stroke, and hypertension. In addition, mutations in the APLR gene have been linked to a number of cancers, including breast cancer, lung cancer, and colon cancer.

Genular Protein ID: 2653762008

Symbol: APJ_HUMAN

Name: Apelin receptor

UniProtKB Accession Codes:

P35414

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 12 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8294032

Title: A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11.

PubMed ID: 8294032

DOI: 10.1016/0378-1119(93)90495-o

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11090199

Title: Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry.

PubMed ID: 11090199

DOI: 10.1128/jvi.74.24.11972-11976.2000

PubMed ID: 25639753

Title: Elabela-apelin receptor signaling pathway is functional in mammalian systems.

PubMed ID: 25639753

DOI: 10.1038/srep08170

PubMed ID: 28137936

Title: Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension.

PubMed ID: 28137936

DOI: 10.1161/circulationaha.116.023218

Sequence Information:

  • Length: 380
  • Mass: 42660
  • Checksum: 78DB18BEA6D2B2E4
  • Sequence:
    • MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK 
RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL 
TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ 
CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL 
RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV 
NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK 
GGEQMHEKSI PYSQETLVVD

Genular Protein ID: 1878646929

Symbol: B3KQN4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KQN4

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 2 SUPFAM 1

Citations:

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 380
  • Mass: 42689
  • Checksum: 78D9CA6EA6D2B1E7
  • Sequence:
    • MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK 
RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL 
TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ 
CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL 
RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV 
NSCLNPFLYA FFDPRFRRAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK 
GGEQMHEKSI PYSQETLVVD

Genular Protein ID: 412901375

Symbol: B2RDH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RDH3

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 380
  • Mass: 42790
  • Checksum: 53B6AB649B7161A9
  • Sequence:
    • MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK 
RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL 
TGLSFDRYLA IVRPVANARL RLRVSWAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ 
CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL 
RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV 
NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK 
GGEQMHEKSI PYSQETLVVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.