Genular: Defining Cellular Identity and Function

Details for: Pik3ca

Gene ID: 18706

Symbol: Pik3ca

Ensembl ID: ENSMUSG00000027665

Description: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

Associated with

Adaptive immune system
(R-MMU-1280218)
Axon guidance
(R-MMU-422475)
Cd28 co-stimulation
(R-MMU-389356)
Cd28 dependent pi3k/akt signaling
(R-MMU-389357)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Costimulation by the cd28 family
(R-MMU-388841)
Cytokine signaling in immune system
(R-MMU-1280215)
Dap12 interactions
(R-MMU-2172127)
Dap12 signaling
(R-MMU-2424491)
Developmental biology
(R-MMU-1266738)
Downstream signaling of activated fgfr1
(R-MMU-5654687)
Downstream signaling of activated fgfr2
(R-MMU-5654696)
Downstream signaling of activated fgfr3
(R-MMU-5654708)
Downstream signaling of activated fgfr4
(R-MMU-5654716)
Downstream signal transduction
(R-MMU-186763)
Downstream tcr signaling
(R-MMU-202424)
Erythropoietin activates phosphoinositide-3-kinase (pi3k)
(R-MMU-9027276)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-MMU-2029480)
Flt3 signaling
(R-MMU-9607240)
Gab1 signalosome
(R-MMU-180292)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Gpvi-mediated activation cascade
(R-MMU-114604)
Hemostasis
(R-MMU-109582)
Igf1r signaling cascade
(R-MMU-2428924)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Insulin receptor signalling cascade
(R-MMU-74751)
Interleukin-2 family signaling
(R-MMU-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-MMU-512988)
Interleukin receptor shc signaling
(R-MMU-912526)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irs-mediated signalling
(R-MMU-112399)
Irs-related events triggered by igf1r
(R-MMU-2428928)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Met activates pi3k/akt signaling
(R-MMU-8851907)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Nervous system development
(R-MMU-9675108)
Phospholipid metabolism
(R-MMU-1483257)
Pi-3k cascade:fgfr1
(R-MMU-5654689)
Pi-3k cascade:fgfr2
(R-MMU-5654695)
Pi-3k cascade:fgfr3
(R-MMU-5654710)
Pi-3k cascade:fgfr4
(R-MMU-5654720)
Pi3k/akt activation
(R-MMU-198203)
Pi3k cascade
(R-MMU-109704)
Pi3k events in erbb2 signaling
(R-MMU-1963642)
Pi3k events in erbb4 signaling
(R-MMU-1250342)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pi metabolism
(R-MMU-1483255)
Pip3 activates akt signaling
(R-MMU-1257604)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Rac1 gtpase cycle
(R-MMU-9013149)
Rac2 gtpase cycle
(R-MMU-9013404)
Raf/map kinase cascade
(R-MMU-5673001)
Regulation of signaling by cbl
(R-MMU-912631)
Ret signaling
(R-MMU-8853659)
Rho gtpase cycle
(R-MMU-9012999)
Role of lat2/ntal/lab on calcium mobilization
(R-MMU-2730905)
Role of phospholipids in phagocytosis
(R-MMU-2029485)
Signaling by alk
(R-MMU-201556)
Signaling by egfr
(R-MMU-177929)
Signaling by erbb2
(R-MMU-1227986)
Signaling by erbb4
(R-MMU-1236394)
Signaling by erythropoietin
(R-MMU-9006335)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by fgfr3
(R-MMU-5654741)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by gpcr
(R-MMU-372790)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by interleukins
(R-MMU-449147)
Signaling by met
(R-MMU-6806834)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by pdgf
(R-MMU-186797)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by scf-kit
(R-MMU-1433557)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-MMU-2404192)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Synthesis of pips at the plasma membrane
(R-MMU-1660499)
Tcr signaling
(R-MMU-202403)
Tie2 signaling
(R-MMU-210993)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
1-phosphatidylinositol-3-kinase activity
(GO:0016303)
Atp binding
(GO:0005524)
Kinase activity
(GO:0016301)
Nucleotide binding
(GO:0000166)
Protein binding
(GO:0005515)
Protein serine/threonine kinase activity
(GO:0004674)

Other Information

Proteins

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Genular Protein ID: 1799199481

Symbol: PK3CA_MOUSE

Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

UniProtKB Accession Codes:

P42337 Q0VGQ5

Database IDs:

Citations:

PubMed ID: 8139567

Title: The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity.

PubMed ID: 8139567

DOI: 10.1128/mcb.14.4.2675-2685.1994

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15197263

Title: Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase.

PubMed ID: 15197263

DOI: 10.1073/pnas.0403328101

PubMed ID: 16647110

Title: A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.

PubMed ID: 16647110

DOI: 10.1016/j.cell.2006.03.035

PubMed ID: 16625210

Title: Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.

PubMed ID: 16625210

DOI: 10.1038/nature04694

PubMed ID: 17060635

Title: The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation.

PubMed ID: 17060635

DOI: 10.1073/pnas.0607899103

PubMed ID: 17540175

Title: Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.

PubMed ID: 17540175

DOI: 10.1016/j.cell.2007.03.051

PubMed ID: 18449193

Title: Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

PubMed ID: 18449193

DOI: 10.1038/nature06892

PubMed ID: 19604150

Title: Specific role of phosphoinositide 3-kinase p110alpha in the regulation of phagocytosis and pinocytosis in macrophages.

PubMed ID: 19604150

DOI: 10.1042/bj20090687

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21540297

Title: VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells.

PubMed ID: 21540297

DOI: 10.1242/jcs.077594

Sequence Information:

Length: 1068
Mass: 124412
Checksum: D593283B416ABFD0
Sequence:

MPPRPSSGEL WGIHLMPPRI LVECLLPNGM IVTLECLREA TLVTIKHELF REARKYPLHQ 
LLQDETSYIF VSVTQEAERE EFFDETRRLC DLRLFQPFLK VIEPVGNREE KILNREIGFV 
IGMPVCEFDM VKDPEVQDFR RNILNVCKEA VDLRDLNSPH SRAMYVYPPN VESSPELPKH 
IYNKLDKGQI IVVIWVIVSP NNDKQKYTLK INHDCVPEQV IAEAIRKKTR SMLLSSEQLK 
LCVLEYQGKY ILKVCGCDEY FLEKYPLSQY KYIRSCIMLG RMPNLMLMAK ESLYSQLPID 
SFTMPSYSRR ISTATPYMNG ETSTKSLWVI NSALRIKILC ATYVNVNIRD IDKIYVRTGI 
YHGGEPLCDN VNTQRVPCSN PRWNEWLNYD IYIPDLPRAA RLCLSICSVK GRKGAKEEHC 
PLAWGNINLF DYTDTLVSGK MALNLWPVPH GLEDLLNPIG VTGSNPNKET PCLELEFDWF 
SSVVKFPDMS VIEEHANWSV SREAGFSYSH TGLSNRLARD NELRENDKEQ LRALCTRDPL 
SEITEQEKDF LWSHRHYCVT IPEILPKLLL SVKWNSRDEV AQMYCLVKDW PPIKPEQAME 
LLDCNYPDPM VRSFAVRCLE KYLTDDKLSQ YLIQLVQVLK YEQYLDNLLV RFLLKKALTN 
QRIGHFFFWH LKSEMHNKTV SQRFGLLLES YCRACGMYLK HLNRQVEAME KLINLTDILK 
QEKKDETQKV QMKFLVEQMR QPDFMDALQG FLSPLNPAHQ LGNLRLEECR IMSSAKRPLW 
LNWENPDIMS ELLFQNNEII FKNGDDLRQD MLTLQIIRIM ENIWQNQGLD LRMLPYGCLS 
IGDCVGLIEV VRNSHTIMQI QCKGGLKGAL QFNSHTLHQW LKDKNKGEIY DAAIDLFTRS 
CAGYCVATFI LGIGDRHNSN IMVKDDGQLF HIDFGHFLDH KKKKFGYKRE RVPFVLTQDF 
LIVISKGAQE YTKTREFERF QEMCYKAYLA IRQHANLFIN LFSMMLGSGM PELQSFDDIA 
YIRKTLALDK TEQEALEYFT KQMNDAHHGG WTTKMDWIFH TIKQHALN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pik3ca

Associated with

Other Information

The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. PubMed ID: 8139567

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase. PubMed ID: 15197263

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. PubMed ID: 16647110

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. PubMed ID: 16625210

The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. PubMed ID: 17060635

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. PubMed ID: 17540175

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. PubMed ID: 18449193

Specific role of phosphoinositide 3-kinase p110alpha in the regulation of phagocytosis and pinocytosis in macrophages. PubMed ID: 19604150

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells. PubMed ID: 21540297