Details for: Pik3r1

Gene ID: 18708

Symbol: Pik3r1

Ensembl ID: ENSMUSG00000041417

Description: phosphoinositide-3-kinase regulatory subunit 1

Associated with

Other Information

Genular Protein ID: 1564965171

Symbol: P85A_MOUSE

Name: Phosphatidylinositol 3-kinase regulatory subunit alpha

UniProtKB Accession Codes:

P26450 Q8K3B3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 5 CORUM 1 CTD 1 ChEMBL 3 ChiTaRS 1 DIP 1 DNASU 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 87 Gene3D 4 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 3 PaxDb 1 PeptideAtlas 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 54 RefSeq 1 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1849460

Title: cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor.

PubMed ID: 1849460

DOI: 10.1016/0092-8674(91)90409-r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1646396

Title: Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction.

PubMed ID: 1646396

DOI: 10.1128/mcb.11.7.3780-3785.1991

PubMed ID: 8128248

Title: Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit.

PubMed ID: 8128248

DOI: 10.1126/science.8128248

PubMed ID: 8943348

Title: Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.

PubMed ID: 8943348

DOI: 10.1128/mcb.16.12.6926

PubMed ID: 9312046

Title: Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling.

PubMed ID: 9312046

DOI: 10.1093/emboj/16.19.5880

PubMed ID: 10521483

Title: Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.

PubMed ID: 10521483

DOI: 10.1074/jbc.274.43.30896

PubMed ID: 10528161

Title: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties.

PubMed ID: 10528161

PubMed ID: 10353604

Title: Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase.

PubMed ID: 10353604

DOI: 10.1038/sj.onc.1202612

PubMed ID: 11006284

Title: The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinase.

PubMed ID: 11006284

DOI: 10.1074/jbc.m006665200

PubMed ID: 10646608

Title: Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.

PubMed ID: 10646608

DOI: 10.1038/35003228

PubMed ID: 11294897

Title: Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation.

PubMed ID: 11294897

DOI: 10.1091/mbc.12.4.931

PubMed ID: 11113178

Title: Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling.

PubMed ID: 11113178

DOI: 10.1128/mcb.21.1.26-38.2001

PubMed ID: 11526404

Title: Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

PubMed ID: 11526404

DOI: 10.1038/ni0901-870

PubMed ID: 11711534

Title: 'Srcasm: a novel Src activating and signaling molecule.

PubMed ID: 11711534

DOI: 10.1074/jbc.m106813200

PubMed ID: 12052866

Title: SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.

PubMed ID: 12052866

DOI: 10.1128/mcb.22.13.4567-4578.2002

PubMed ID: 14610044

Title: LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.

PubMed ID: 14610044

DOI: 10.1084/jem.20030232

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16249387

Title: LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.

PubMed ID: 16249387

DOI: 10.1182/blood-2005-05-1859

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20348926

Title: The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation.

PubMed ID: 20348926

DOI: 10.1038/nm.2099

PubMed ID: 25328665

Title: Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway.

PubMed ID: 25328665

DOI: 10.1186/2045-3701-4-60

PubMed ID: 27708159

Title: Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.

PubMed ID: 27708159

DOI: 10.1073/pnas.1614467113

Sequence Information:

  • Length: 724
  • Mass: 83517
  • Checksum: 9975D7AD8BABBA9C
  • Sequence:
    • MSAEGYQYRA LYDYKKEREE DIDLHLGDIL TVNKGSLVAL GFSDGQEARP EDIGWLNGYN 
ETTGERGDFP GTYVEYIGRK RISPPTPKPR PPRPLPVAPG SSKTEADTEQ QALPLPDLAE 
QFAPPDVAPP LLIKLLEAIE KKGLECSTLY RTQSSSNPAE LRQLLDCDAA SVDLEMIDVH 
VLADAFKRYL ADLPNPVIPV AVYNEMMSLA QELQSPEDCI QLLKKLIRLP NIPHQCWLTL 
QYLLKHFFKL SQASSKNLLN ARVLSEIFSP VLFRFPAASS DNTEHLIKAI EILISTEWNE 
RQPAPALPPK PPKPTTVANN SMNNNMSLQD AEWYWGDISR EEVNEKLRDT ADGTFLVRDA 
STKMHGDYTL TLRKGGNNKL IKIFHRDGKY GFSDPLTFNS VVELINHYRN ESLAQYNPKL 
DVKLLYPVSK YQQDQVVKED NIEAVGKKLH EYNTQFQEKS REYDRLYEEY TRTSQEIQMK 
RTAIEAFNET IKIFEEQCQT QERYSKEYIE KFKREGNEKE IQRIMHNHDK LKSRISEIID 
SRRRLEEDLK KQAAEYREID KRMNSIKPDL IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN 
ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN RNKAENLLRG KRDGTFLVRE SSKQGCYACS 
VVVDGEVKHC VINKTATGYG FAEPYNLYSS LKELVLHYQH TSLVQHNDSL NVTLAYPVYA 
QQRR

Genular Protein ID: 4169592943

Symbol: Q8C7P2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C7P2

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 1 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 RefSeq 2 SAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 109
  • Mass: 12170
  • Checksum: DCE0EA70AE10B329
  • Sequence:
    • MYNVHGLFPI HLSATQIHSQ VQVHNKQMSS TGLVYVCVCV CVCVCVFLYF FAIALFCLIK 
YNLSTSEVRS PSFDTFLFLE ALPFQGAAWM ICLPDGSLFS VLSSQSVFL

Genular Protein ID: 2244988169

Symbol: Q80UI5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q80UI5

Database IDs:

AGR 1 ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 2 GeneTree 1 HOGENOM 1 IntAct 1 InterPro 6 MGI 2 MINT 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PROSITE-ProRule 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 454
  • Mass: 53399
  • Checksum: 543B736F6439FFFF
  • Sequence:
    • MYTTVWTMED LDLECAKTDI NCGTDLVFYI EMDPPALPPK PPKPTTVANN SMNNNMSLQD 
AEWYWGDISR EEVNEKLRDT ADGTFLVRDA STKMHGDYTL TLRKGGNNKL IKIFHRDGKY 
GFSDPLTFNS VVELINHYRN ESLAQYNPKL DVKLLYPVSK YQQDQVVKED NIEAVGKKLH 
EYNTQFQEKS REYDRLYEEY TRTSQEIQMK RTAIEAFNET IKIFEEQCQT QERYSKEYIE 
KFKREGNEKE IQRIMHNHDK LKSRISEIID SRRRLEEDLK KQAAEYREID KRMNSIKPDL 
IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN 
RNKAENLLRG KRDGTFLVRE SSKQGCYACS VVVDGEVKHC VINKTATGYG FAEPYNLYSS 
LKELVLHYQH TSLVQHNDSL NVTLAYPVYA QQRR

Genular Protein ID: 827926848

Symbol: Q3TP23_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TP23

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 InterPro 3 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 2 SMART 1 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 106
  • Mass: 12004
  • Checksum: A78E3DEBE99DD7E9
  • Sequence:
    • HDEKTWNVGS SNRNKAENLL RGKRDGTFLV RESSKQGCYA CSVVVDGEVK HCVINKTATG 
YGFAEPYNLY SSLKELVLHY QHTSLVQHND SLNVTLAYPV YAQQRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.