Genular: Defining Cellular Identity and Function

Details for: Pik3r2

Gene ID: 18709

Symbol: Pik3r2

Ensembl ID: ENSMUSG00000031834

Description: phosphoinositide-3-kinase regulatory subunit 2

Associated with

Adaptive immune system
(R-MMU-1280218)
Axon guidance
(R-MMU-422475)
Cd28 co-stimulation
(R-MMU-389356)
Cd28 dependent pi3k/akt signaling
(R-MMU-389357)
Cdc42 gtpase cycle
(R-MMU-9013148)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Costimulation by the cd28 family
(R-MMU-388841)
Cytokine signaling in immune system
(R-MMU-1280215)
Dap12 interactions
(R-MMU-2172127)
Dap12 signaling
(R-MMU-2424491)
Developmental biology
(R-MMU-1266738)
Downstream signal transduction
(R-MMU-186763)
Downstream tcr signaling
(R-MMU-202424)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-MMU-2029480)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Gpvi-mediated activation cascade
(R-MMU-114604)
Hemostasis
(R-MMU-109582)
Igf1r signaling cascade
(R-MMU-2428924)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Insulin receptor signalling cascade
(R-MMU-74751)
Interleukin-2 family signaling
(R-MMU-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-MMU-512988)
Interleukin-7 signaling
(R-MMU-1266695)
Interleukin receptor shc signaling
(R-MMU-912526)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irs-mediated signalling
(R-MMU-112399)
Irs-related events triggered by igf1r
(R-MMU-2428928)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Nervous system development
(R-MMU-9675108)
Phospholipid metabolism
(R-MMU-1483257)
Pi3k/akt activation
(R-MMU-198203)
Pi3k cascade
(R-MMU-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pi metabolism
(R-MMU-1483255)
Pip3 activates akt signaling
(R-MMU-1257604)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Rac1 gtpase cycle
(R-MMU-9013149)
Rac2 gtpase cycle
(R-MMU-9013404)
Rac3 gtpase cycle
(R-MMU-9013423)
Raf/map kinase cascade
(R-MMU-5673001)
Regulation of signaling by cbl
(R-MMU-912631)
Ret signaling
(R-MMU-8853659)
Rhoa gtpase cycle
(R-MMU-8980692)
Rhob gtpase cycle
(R-MMU-9013026)
Rhod gtpase cycle
(R-MMU-9013405)
Rhof gtpase cycle
(R-MMU-9035034)
Rho gtpase cycle
(R-MMU-9012999)
Rhoj gtpase cycle
(R-MMU-9013409)
Rhou gtpase cycle
(R-MMU-9013420)
Rnd1 gtpase cycle
(R-MMU-9696273)
Rnd2 gtpase cycle
(R-MMU-9696270)
Rnd3 gtpase cycle
(R-MMU-9696264)
Role of lat2/ntal/lab on calcium mobilization
(R-MMU-2730905)
Role of phospholipids in phagocytosis
(R-MMU-2029485)
Signaling by alk
(R-MMU-201556)
Signaling by gpcr
(R-MMU-372790)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by interleukins
(R-MMU-449147)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by pdgf
(R-MMU-186797)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by scf-kit
(R-MMU-1433557)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-MMU-2404192)
Signaling by vegf
(R-MMU-194138)
Synthesis of pips at the plasma membrane
(R-MMU-1660499)
Tcr signaling
(R-MMU-202403)
Tie2 signaling
(R-MMU-210993)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
1-phosphatidylinositol-3-kinase regulator activity
(GO:0046935)
Cellular response to insulin stimulus
(GO:0032869)
Insulin receptor signaling pathway
(GO:0008286)
Intracellular glucose homeostasis
(GO:0001678)
Negative regulation of mapk cascade
(GO:0043409)
Phosphatidylinositol 3-kinase regulatory subunit binding
(GO:0036312)
Phosphotyrosine residue binding
(GO:0001784)
Positive regulation of protein import into nucleus
(GO:0042307)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein phosphatase binding
(GO:0019903)
Protein transport
(GO:0015031)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of actin filament polymerization
(GO:0030833)
Regulation of autophagy
(GO:0010506)
Response to endoplasmic reticulum stress
(GO:0034976)
Signal transduction
(GO:0007165)

Other Information

Proteins

Phosphatidylinositol 3-kinase regulatory subunit beta

Genular Protein ID: 4156798264

Symbol: P85B_MOUSE

Name: Phosphatidylinositol 3-kinase regulatory subunit beta

UniProtKB Accession Codes:

O08908 Q5U3K7

Database IDs:

Citations:

PubMed ID: 9582025

Title: An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme.

PubMed ID: 9582025

DOI: 10.1038/sj.onc.1201695

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16452087

Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

PubMed ID: 16452087

DOI: 10.1074/mcp.t500041-mcp200

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20348926

Title: The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation.

PubMed ID: 20348926

DOI: 10.1038/nm.2099

PubMed ID: 21946561

Title: NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.

PubMed ID: 21946561

DOI: 10.1038/emboj.2011.348

Sequence Information:

Length: 722
Mass: 81266
Checksum: A999FAF9011455FE
Sequence:

MAGAEGFQYR AVYPFRRERP EDLELLPGDL LVVSRVALQA LGVADGGERC PHNVGWMPGF 
NERTRQRGDF PGTYVEFLGP VALARPGPRP RGPRPLPARP LDGSSESGHI LPDLAEQFSP 
PDPAPPILVK LVEAIEQAEL DSECYSKPEL PATRTDWSLS DLEQWDRTAL YDAVKGFLLA 
LPAAVVTPEA AAEAYRALRE VAGPVGLVLE PPTLPLHQAL TLRFLLQHLG RVARRAPSPD 
TAVHALASAF GPLLLRIPPS GGEGDGSEPV PDFPVLLLER LVQEHVEEQD AAPPALPPKP 
SKAKPAPTAL ANGGSPPSLQ DAEWYWGDIS REEVNERLRD TPDGTFLVRD ASSKIQGEYT 
LTLRKGGNNK LIKVFHRDGH YGFSEPLTFC SVVELISHYR HESLAQYNAK LDTRLLYPVS 
KYQQDQVVKE DSIEAVGAQL KVYHQQYQDK SREYDQLYEE YTRTSQELQM KRTAIEAFNE 
TIKIFEEQGQ TQEKCSKEYL ERFRREGNEK EMQRILLNSE RLKSRIAEIH ESRTKLEQDL 
RAQASDNREI DKRMNSLKPD LMQLRKIRDQ YLVWLTQKGA RQRKINEWLG IKNETEDQYS 
LMEDEDALPH HEERTWYVGK INRTQAEEML SGKRDGTFLI RESSQRGCYA CSVVVDGDTK 
HCVIYRTATG FGFAEPYNLY GSLKELVLHY QHASLVQHND ALTVTLAHPV RAPGPGPPSA 
AR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pik3r2

Associated with

Other Information

An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme. PubMed ID: 9582025

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Comprehensive identification of phosphorylation sites in postsynaptic density preparations. PubMed ID: 16452087

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. PubMed ID: 20348926

NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. PubMed ID: 21946561