Details for: Pikfyve
Associated with
Other Information
Genular Protein ID: 2990561644
Symbol: FYV1_MOUSE
Name: FYVE finger-containing phosphoinositide kinase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9858586
Title: Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells.
PubMed ID: 9858586
DOI: 10.1128/mcb.19.1.623
PubMed ID: 15368895
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
PubMed ID: 15368895
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 10567352
Title: Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases.
PubMed ID: 10567352
PubMed ID: 10419465
Title: PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin.
PubMed ID: 10419465
PubMed ID: 11123925
Title: PIKfyve lipid kinase is a protein kinase: downregulation of 5'-phosphoinositide product formation by autophosphorylation.
PubMed ID: 11123925
DOI: 10.1021/bi001897f
PubMed ID: 14530284
Title: Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40.
PubMed ID: 14530284
PubMed ID: 17242355
Title: Large-scale phosphorylation analysis of mouse liver.
PubMed ID: 17242355
PubMed ID: 17956977
Title: Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.
PubMed ID: 17956977
PubMed ID: 17909029
Title: The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus.
PubMed ID: 17909029
PubMed ID: 19037259
Title: VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.
PubMed ID: 19037259
PubMed ID: 19056739
Title: Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin.
PubMed ID: 19056739
PubMed ID: 20513353
Title: Regulation of PIKfyve phosphorylation by insulin and osmotic stress.
PubMed ID: 20513353
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 21349843
Title: The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.
PubMed ID: 21349843
PubMed ID: 22621786
Title: Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.
PubMed ID: 22621786
PubMed ID: 23673157
Title: Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching.
PubMed ID: 23673157
PubMed ID: 25178411
Title: Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.
PubMed ID: 25178411
DOI: 10.1038/ncomms5691
PubMed ID: 27623384
Title: PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.
PubMed ID: 27623384
PubMed ID: 28779020
Title: The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase.
PubMed ID: 28779020
PubMed ID: 29584722
Title: PIKfyve regulates melanosome biogenesis.
PubMed ID: 29584722
PubMed ID: 31427458
Title: PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice.
PubMed ID: 31427458
DOI: 10.1128/mcb.00158-19
Sequence Information:
- Length: 2097
- Mass: 236877
- Checksum: 8C529E86FBEED8E6
- Sequence:
MATDDKSSPT LDSANDLPRS PASPSHLTHF KPLTPDQDEP PFKSAYSSFV NLFRFNKERG EGGQGEQQSP SSSWASPQIP SRTQSVRSPV PYKKQLNEEL HRRSSVLDSR RKAEPACGGH DPRTAVQLRS LSTVLKRLKE IMEGKSQDSD LKQYWMPDSQ CKECYDCSEK FTTFRRRHHC RLCGQIFCSR CCNQEIPGKF MGYTGDLRAC TYCRKIALSY AHSTDSNSIG EDLNALSDST CSVSILDPSE PRTPVGSRKA SRNIFLEDDL AWQSLIHPDS SNSALSTRLV SVQEDAGKSP ARNRSASITN LSLDRSGSPM VPSYETSVSP QANRNYIRTE TTEDERKILL DSAQLKDLWK KICHHTSGME FQDHRYWLRT HPNCIVGKEL VNWLIRNGHI ATRAQAIAIG QAMVDGRWLD CVSHHDQLFR DEYALYRPLQ STEFSETPSP DSDSVNSVEG HSEPSWFKDI KFDDSDTEQI AEEGDDNLAN SASPSKRTSV SSFQSTVDSD SAASISLNVE LDNVNFHIKK PSKYPHVPPH PADQKEYLVS DTGGQQLSIS DAFIKESLFN RRVEEKSKEL PFTPLGWHHN NLELLREENE EKQAMERLLS ANHNHMMALL QQLLQNESLS SSWRDIIVSL VCQVVQTVRP DVKHQDDDMD IRQFVHIKKI PGGKKFDSVV VNGFVCTKNI AHKKMNSCIK NPKILLLKCS IEYLYREETK FTCIDPIVLQ EREFLKNYVQ RIVDVRPTLV LVEKTVSRIA QDMLLEHGIT LVINVKSQVL ERISRMTQGD LVVSMDQLLT KPHLGTCHKF YMQIFQLPNE QTKTLMFFEG CPQHLGCTIK LRGGSDYELA RVKEILIFMI CVAYHSQLEI SFLMDEFAMP PTLMQSPSFH LLTEGRGEEG ASQEQVSGSS LPQDPECPRE ALSSEDSTLL ESRTVLEKGE LDNKSIPQAV ASLKHQDYTT PTCPAGIPCA LFALVPESLL PLHMDQQDAV GNEQPETSQQ TDEQQDPKSQ MKAFRDPLQD DTGMYVTEEV TSSEDQRKTY ALTFKQELKD VILCISPVIT FREPFLLTEK GMRCSTRDYF PEQIYWSPLL NKEVKEMESR RKKQLLRDLS GLQGMNGSVQ AKSIQVLPSH ELVSTRIAEH LGDSQTLGRM LADYRARGGR IQSKHLDPFV HSKDASCTSG GKSGNKTESD EERGLIPSDV IWPTKVDCLN PANHQRLCVL FSSSSAQSSN APSACVSPWI VTMEFYGKND LTLGIFLERY CFRSSYQCPS MFCDTPMVHH IRRFVHGQGC VQIILKELDS PVPGYQHTIL TYSWCRICKQ VTPVVALSNE SWSMSFAKYL ELRFYGHQYT RRANAEPCGH SIHHDYHQYF SYNQMVASFS YSPIRLLEVC VPLPKIFIKR QAPLKVSLLQ DLKDFFQKVS QVYLAVDERL ASLKTDTFSK TREEKMEDIF AQKEMEEGEF KNWTEKMQAR LMSSSVDTPQ QLQSIFESLI AKKQSLCEVL QAWNSRLQDL FQQEKGRKRP SVPPSPGRLR QGEESKINAM DTSPRNISPG LHNGEKEDRF LTTLSSQSST SSTHLQLPTP PEALAEQVVG GPTDLDSASG SEDVFDGHLL GSTDSQVKEK STMKAIFANL LPGNSYNPIP FPFDPDKHYL MYEHERVPIA VCEKEPSSII AFALSCKEYR NALEELSKAT LRNSAEEGLP ANSALDNRPK SSSPIRLPEI SGGQTNRTVE AEPQPTKKAS GMLSFFRGTA GKSPDLSSQK RETLRGADSA YYQVGQAGKE GLESQGLEPQ DEVDGGDTQK KQLTNPHVEL QFSDANAKFY CRLYYAGEFH KMREVILGSS EEEFIRSLSH SSPWQARGGK SGAAFYATED DRFILKQMPR LEVQSFLDFA PHYFNYITNA VQQKRPTALA KILGVYRIGY KNSQNNTEKK LDLLVMENLF YGRKMAQVFD LKGSLRNRNV KTDTGKESCD VVLLDENLLK MVRDNPLYIR SHSKSVLRTS IHSDAHFLSS HLIIDYSLLV GRDDTSNELV VGIIDYIRTF TWDKKLEMVV KSTGILGGQG KMPTVVSPEL YRTRFCEAMD KYFLMVPDHW TGLDLNC
Genular Protein ID: 3539973114
Symbol: D3Z5N5_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 17242355
Title: Large-scale phosphorylation analysis of mouse liver.
PubMed ID: 17242355
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
Sequence Information:
- Length: 2052
- Mass: 232080
- Checksum: FA7B14B44651C100
- Sequence:
MATDDKSSPT LDSANDLPRS PASPSHLTHF KPLTPDQDEP PFKSAYSSFV NLFRFNKERG EGGQGEQQSP SSSWASPQIP SRTQSVRSPV PYKKQLNEEL HRRSSVLENT LPHPQESTDS RRKAEPACGG HDPRTAVQLR SLSTVLKRLK EIMEGKSQDS DLKQYWMPDS QCKECYDCSE KFTTFRRRHH CRLCGQIFCS RCCNQEIPGK FMGYTGDLRA CTYCRKIALS YAHSTDSNSI GEDLNALSDS TCSVSILDPS EPRTPVGSRK ASRNIFLEDD LAWQSLIHPD SSNSALSTRL VSVQEDAGKS PARNRSASIT NLSLDRSGSP MVPSYETSVS PQANRNYIRT ETTEDERKIL LDSAQLKDLW KKICHHTSGM EFQDHRYWLR THPNCIVGKE LVNWLIRNGH IATRAQAIAI GQAMVDGRWL DCVSHHDQLF RDEYALYRPL QSTEFSETPS PDSDSVNSVE GHSEPSWFKD IKFDDSDTEQ IAEEGDDNLA KYLVSDTGGQ QLSISDAFIK ESLFNRRVEE KSKELPFTPL GWHHNNLELL REENEEKQAM ERLLSANHNH MMALLQQLLQ NESLSSSWRD IIVSLVCQVV QTVRPDVKHQ DDDMDIRQFV HIKKIPGGKK FDSVVVNGFV CTKNIAHKKM NSCIKNPKIL LLKCSIEYLY REETKFTCID PIVLQEREFL KNYVQRIVDV RPTLVLVEKT VSRIAQDMLL EHGITLVINV KSQVLERISR MTQGDLVVSM DQLLTKPHLG TCHKFYMQIF QLPNEQTKTL MFFEGCPQHL GCTIKLRGGS DYELARVKEI LIFMICVAYH SQLEISFLMD EFAMPPTLMQ SPSFHLLTEG RGEEGASQEQ VSGSSLPQDP ECPREALSSE DSTLLESRTV LEKGELDNKS IPQAVASLKH QDYTTPTCPA GIPCALFALV PESLLPLHMD QQDAVGNEQP ETSQQTDEQQ DPKSQMKAFR DPLQDDTGMY VTEEVTSSED QRKTYALTFK QELKDVILCI SPVITFREPF LLTEKGMRCS TRDYFPEQIY WSPLLNKEVK EMESRRKKQL LRDLSGLQGM NGSVQAKSIQ VLPSHELVST RIAEHLGDSQ TLGRMLADYR ARGGRIQSKH LDPFVHSKDA SCTSGGKSGN KTESDEERGL IPSDVIWPTK VDCLNPANHQ RLCVLFSSSS AQSSNAPSAC VSPWIVTMEF YGKNDLTLGI FLERYCFRSS YQCPSMFCDT PMVHHIRRFV HGQGCVQIIL KELDSPVPGY QHTILTYSWC RICKQVTPVV ALSNESWSMS FAKYLELRFY GHQYTRRANA EPCGHSIHHD YHQYFSYNQM VASFSYSPIR LLEVCVPLPK IFIKRQAPLK VSLLQDLKDF FQKVSQVYLA VDERLASLKT DTFSKTREEK MEDIFAQKEM EEGEFKNWTE KMQARLMSSS VDTPQQLQSI FESLIAKKQS LCEVLQAWNS RLQDLFQQEK GRKRPSVPPS PGRLRQGEES KINAMDTSPR NISPGLHNGE KEDRFLTTLS SQSSTSSTHL QLPTPPEALA EQVVGGPTDL DSASGSEDVF DGHLLGSTDS QVKEKSTMKA IFANLLPGNS YNPIPFPFDP DKHYLMYEHE RVPIAVCEKE PSSIIAFALS CKEYRNALEE LSKATLRNSA EEGLPANSAL DNRPKSSSPI RLPEISGGQT NRTVEAEPQP TKKASGMLSF FRGTAGKSPD LSSQKRETLR GADSAYYQVG QAGKEGLESQ GLEPQDEVDG GDTQKKQLTN PHVELQFSDA NAKFYCRLYY AGEFHKMREV ILGSSEEEFI RSLSHSSPWQ ARGGKSGAAF YATEDDRFIL KQMPRLEVQS FLDFAPHYFN YITNAVQQKR PTALAKILGV YRIGYKNSQN NTEKKLDLLV MENLFYGRKM AQVFDLKGSL RNRNVKTDTG KESCDVVLLD ENLLKMVRDN PLYIRSHSKS VLRTSIHSDA HFLSSHLIID YSLLVGRDDT SNELVVGIID YIRTFTWDKK LEMVVKSTGI LGGQGKMPTV VSPELYRTRF CEAMDKYFLM VPDHWTGLDL NC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.