Details for: Pim1

Gene ID: 18712

Symbol: Pim1

Ensembl ID: ENSMUSG00000024014

Description: proviral integration site 1

Associated with

Other Information

Genular Protein ID: 490008224

Symbol: PIM1_MOUSE

Name: Serine/threonine-protein kinase pim-1

UniProtKB Accession Codes:

P06803 F6XDQ5 Q8CFN8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DNASU 1 EC 3 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneTree 1 HOGENOM 1 InParanoid 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 1 Rhea 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 3015420

Title: The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases.

PubMed ID: 3015420

DOI: 10.1016/0092-8674(86)90886-x

PubMed ID: 1825810

Title: The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG.

PubMed ID: 1825810

DOI: 10.1002/j.1460-2075.1991.tb07994.x

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7689870

Title: Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells.

PubMed ID: 7689870

PubMed ID: 8228813

Title: Pim-1 levels determine the size of early B lymphoid compartments in bone marrow.

PubMed ID: 8228813

DOI: 10.1084/jem.178.5.1665

PubMed ID: 10931201

Title: PAP-1, a novel target protein of phosphorylation by Pim-1 kinase.

PubMed ID: 10931201

DOI: 10.1046/j.1432-1327.2000.01585.x

PubMed ID: 15280015

Title: Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site.

PubMed ID: 15280015

DOI: 10.1016/j.febslet.2004.06.050

PubMed ID: 15199164

Title: Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors.

PubMed ID: 15199164

DOI: 10.1128/mcb.24.13.6104-6115.2004

PubMed ID: 18438430

Title: Pim kinase-dependent inhibition of c-Myc degradation.

PubMed ID: 18438430

DOI: 10.1038/onc.2008.123

PubMed ID: 19687226

Title: Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration.

PubMed ID: 19687226

DOI: 10.1084/jem.20082074

PubMed ID: 27923061

Title: Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.

PubMed ID: 27923061

DOI: 10.1371/journal.pgen.1006474

PubMed ID: 31548394

Title: Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.

PubMed ID: 31548394

DOI: 10.1073/pnas.1904774116

Sequence Information:

  • Length: 313
  • Mass: 35451
  • Checksum: 1294F16A03B7C7D7
  • Sequence:
    • MLLSKINSLA HLRAAPCNDL HATKLAPGKE KEPLESQYQV GPLLGSGGFG SVYSGIRVAD 
NLPVAIKHVE KDRISDWGEL PNGTRVPMEV VLLKKVSSDF SGVIRLLDWF ERPDSFVLIL 
ERPEPVQDLF DFITERGALQ EDLARGFFWQ VLEAVRHCHN CGVLHRDIKD ENILIDLSRG 
EIKLIDFGSG ALLKDTVYTD FDGTRVYSPP EWIRYHRYHG RSAAVWSLGI LLYDMVCGDI 
PFEHDEEIIK GQVFFRQTVS SECQHLIKWC LSLRPSDRPS FEEIRNHPWM QGDLLPQAAS 
EIHLHSLSPG SSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.