Genular: Defining Cellular Identity and Function

Details for: Pip4k2a

Gene ID: 18718

Symbol: Pip4k2a

Ensembl ID: ENSMUSG00000026737

Description: phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Intracellular signaling by second messengers
(R-MMU-9006925)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Phospholipid metabolism
(R-MMU-1483257)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pi5p regulates tp53 acetylation
(R-MMU-6811555)
Pi metabolism
(R-MMU-1483255)
Pip3 activates akt signaling
(R-MMU-1257604)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through acetylation
(R-MMU-6804758)
Rna polymerase ii transcription
(R-MMU-73857)
Signal transduction
(R-MMU-162582)
Synthesis of pips at the plasma membrane
(R-MMU-1660499)
Synthesis of pips in the nucleus
(R-MMU-8847453)
Transcriptional regulation by tp53
(R-MMU-3700989)
1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate biosynthetic process
(GO:1902635)
1-phosphatidylinositol-4-phosphate 5-kinase activity
(GO:0016308)
1-phosphatidylinositol-5-phosphate 4-kinase activity
(GO:0016309)
Atp binding
(GO:0005524)
Autophagosome
(GO:0005776)
Autophagosome-lysosome fusion
(GO:0061909)
Cell projection
(GO:0042995)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Kinase activity
(GO:0016301)
Lipid metabolic process
(GO:0006629)
Lysosome
(GO:0005764)
Megakaryocyte development
(GO:0035855)
Membrane
(GO:0016020)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphatidylinositol kinase activity
(GO:0052742)
Phosphatidylinositol metabolic process
(GO:0046488)
Phosphatidylinositol phosphate biosynthetic process
(GO:0046854)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of autophagosome assembly
(GO:2000786)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of autophagy
(GO:0010506)
Transferase activity
(GO:0016740)
Vesicle-mediated cholesterol transport
(GO:0090119)

Other Information

Proteins

1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha

Genular Protein ID: 2072714953

Symbol: PI42A_MOUSE

Name: 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha

UniProtKB Accession Codes:

O70172

Database IDs:

Citations:

PubMed ID: 9535851

Title: Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family.

PubMed ID: 9535851

DOI: 10.1074/jbc.273.15.8741

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16434494

Title: Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis.

PubMed ID: 16434494

DOI: 10.1182/blood-2005-07-2755

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20204506

Title: Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II alpha phosphatidylinositol-5-phosphate 4-kinase.

PubMed ID: 20204506

DOI: 10.1007/s11064-010-0146-y

PubMed ID: 29727621

Title: Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.

PubMed ID: 29727621

DOI: 10.1016/j.molcel.2018.03.037

Sequence Information:

Length: 405
Mass: 46152
Checksum: 2D6CC431BDA4D967
Sequence:

MATPGNLGSS VLASKTKTKK KHFVAQKVKL FRASDPLLSV LMWGVNHSIN ELSHVQIPVM 
LMPDDFKAYS KIKVDNHLFN KENMPSHFKF KEYCPMVFRN LRERFGIDDQ DFQNSLTRSA 
PLPNDSQARS GARFHTSYDK RYVIKTITSE DVAEMHNILK KYHQYIVECH GVTLLPQFLG 
MYRLNVDGVE IYVIVTRNVF SHRLSVYRKY DLKGSTVARE ASDKEKAKEL PTLKDNDFIN 
EGQKIYIDDN NKKIFLEKLK KDVEFLAQLK LMDYSLLVGI HDVERAEQEE VECEENDGEE 
EGESDSTHPI GTPPDSPGNT LNSSPPLAPG EFDPNIDVYA IKCHENAPRK EVYFMAIIDI 
LTHYDAKKKA AHAAKTVKHG AGAEISTVNP EQYSKRFLDF IGHIL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pip4k2a

Associated with

Other Information

Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. PubMed ID: 9535851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. PubMed ID: 16434494

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II alpha phosphatidylinositol-5-phosphate 4-kinase. PubMed ID: 20204506