Genular: Defining Cellular Identity and Function

Details for: Pip5k1b

Gene ID: 18719

Symbol: Pip5k1b

Ensembl ID: ENSMUSG00000024867

Description: phosphatidylinositol-4-phosphate 5-kinase, type 1 beta

Associated with

Intracellular signaling by second messengers
(R-MMU-9006925)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Phospholipid metabolism
(R-MMU-1483257)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pi metabolism
(R-MMU-1483255)
Pip3 activates akt signaling
(R-MMU-1257604)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Synthesis of pips at the plasma membrane
(R-MMU-1660499)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Wnt mediated activation of dvl
(R-MMU-201688)
1-phosphatidylinositol-4-phosphate 5-kinase activity
(GO:0016308)
Atp binding
(GO:0005524)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Kinase activity
(GO:0016301)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Nucleotide binding
(GO:0000166)
Phosphatidylinositol biosynthetic process
(GO:0006661)
Phosphatidylinositol kinase activity
(GO:0052742)
Phosphatidylinositol metabolic process
(GO:0046488)
Phosphatidylinositol phosphate biosynthetic process
(GO:0046854)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Transferase activity
(GO:0016740)
Uropod
(GO:0001931)

Other Information

Proteins

PI51B_MOUSE

Genular Protein ID: 2547005660

Symbol: PI51B_MOUSE

Name: N/A

UniProtKB Accession Codes:

P70181 O70335 Q8JZY6

Database IDs:

Citations:

PubMed ID: 8798574

Title: Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol 4-phosphate 5-kinase.

PubMed ID: 8798574

DOI: 10.1074/jbc.271.39.23611

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9367159

Title: A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.

PubMed ID: 9367159

DOI: 10.1038/36621

PubMed ID: 9535851

Title: Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family.

PubMed ID: 9535851

DOI: 10.1074/jbc.273.15.8741

PubMed ID: 10679324

Title: Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly.

PubMed ID: 10679324

DOI: 10.1016/s0960-9822(00)00315-8

PubMed ID: 11032811

Title: Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity.

PubMed ID: 11032811

DOI: 10.1093/emboj/19.20.5440

PubMed ID: 10747863

Title: Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the Golgi compartment.

PubMed ID: 10747863

DOI: 10.1074/jbc.c901019199

PubMed ID: 15870270

Title: The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha.

PubMed ID: 15870270

DOI: 10.1128/mcb.25.10.3956-3966.2005

PubMed ID: 18772378

Title: Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.

PubMed ID: 18772378

DOI: 10.1073/pnas.0804139105

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22942276

Title: Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator.

PubMed ID: 22942276

DOI: 10.1074/jbc.m112.370155

Sequence Information:

Length: 539
Mass: 60803
Checksum: A8478C9E21546AC3
Sequence:

MSSTAENGDA VPGKQNEEKT YKKTASSAIK GAIQLGIGYT VGNLTSKPER DVLMQDFYVV 
ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI KPDDYLYSIC SEPLIELSNP 
GASGSLFFLT SDDEFIIKTV QHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCMQSGG 
INIRIVVMNN VLPRAMRMHL TYDLKGSTYK RRASRKEREK PNPTFKDLDF LQDMHEGLYF 
DTETYNALMK TLQRDCRVLE SFKIMDYSLL LGIHILDHSL KDKEEEPLQN VPDAKRPGMQ 
KVLYSTAMES IQGPGKSADG IIAENPDTMG GIPAKSHKGE KLLLFMGIID ILQSYRLMKK 
LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNSRVFKKIQ ALKASPSKKR CNSIAALKAT 
SQEIVSSISQ EWKDEKRDLL TEGQSFSSLD EEALGSRHRP DLVPSTPSLF EAASLATTIS 
SSSLYVGEHY PHDRTTLYSN SKGLPSSSTF TLEEGTIYLT AEPNTLDLQD DASVLDVYL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pip5k1b

Associated with

Other Information

Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol 4-phosphate 5-kinase. PubMed ID: 8798574

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. PubMed ID: 9367159

Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. PubMed ID: 9535851

Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. PubMed ID: 10679324

Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. PubMed ID: 11032811

Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the Golgi compartment. PubMed ID: 10747863

The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. PubMed ID: 15870270

Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. PubMed ID: 18772378

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator. PubMed ID: 22942276