Genular: Defining Cellular Identity and Function

Details for: Pip5k1a

Gene ID: 18720

Symbol: Pip5k1a

Ensembl ID: ENSMUSG00000028126

Description: phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha

Associated with

Intracellular signaling by second messengers
(R-MMU-9006925)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Phospholipid metabolism
(R-MMU-1483257)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pi metabolism
(R-MMU-1483255)
Pip3 activates akt signaling
(R-MMU-1257604)
Signal transduction
(R-MMU-162582)
Synthesis of pips at the plasma membrane
(R-MMU-1660499)
1-phosphatidylinositol-4-phosphate 5-kinase activity
(GO:0016308)
Actin cytoskeleton organization
(GO:0030036)
Activation of gtpase activity
(GO:0090630)
Atp binding
(GO:0005524)
Cell chemotaxis
(GO:0060326)
Cell projection
(GO:0042995)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Fibroblast migration
(GO:0010761)
Focal adhesion assembly
(GO:0048041)
Kinase activity
(GO:0016301)
Kinase binding
(GO:0019900)
Lamellipodium
(GO:0030027)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Mrna cleavage and polyadenylation specificity factor complex
(GO:0005847)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphatidylinositol biosynthetic process
(GO:0006661)
Phosphatidylinositol kinase activity
(GO:0052742)
Phosphatidylinositol metabolic process
(GO:0046488)
Phosphatidylinositol phosphate biosynthetic process
(GO:0046854)
Phospholipid biosynthetic process
(GO:0008654)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Ruffle assembly
(GO:0097178)
Ruffle membrane
(GO:0032587)
Transferase activity
(GO:0016740)

Other Information

Proteins

PI51A_MOUSE

Genular Protein ID: 2350260457

Symbol: PI51A_MOUSE

Name: N/A

UniProtKB Accession Codes:

P70182 F8WIX5 Q3U917 Q8K0D3 Q99L80

Database IDs:

Citations:

PubMed ID: 8798574

Title: Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol 4-phosphate 5-kinase.

PubMed ID: 8798574

DOI: 10.1074/jbc.271.39.23611

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9535851

Title: Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family.

PubMed ID: 9535851

DOI: 10.1074/jbc.273.15.8741

PubMed ID: 10679324

Title: Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly.

PubMed ID: 10679324

DOI: 10.1016/s0960-9822(00)00315-8

PubMed ID: 18772378

Title: Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.

PubMed ID: 18772378

DOI: 10.1073/pnas.0804139105

PubMed ID: 19153220

Title: Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis.

PubMed ID: 19153220

DOI: 10.1083/jcb.200806121

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20622009

Title: Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain.

PubMed ID: 20622009

DOI: 10.1074/jbc.m110.132191

PubMed ID: 27739494

Title: A novel IRS-1-associated protein, DGKzeta regulates GLUT4 translocation in 3T3-L1 adipocytes.

PubMed ID: 27739494

DOI: 10.1038/srep35438

Sequence Information:

Length: 546
Mass: 60485
Checksum: 6E895F22A75B7140
Sequence:

MASASSGPAA AGFSSLDAGA PAGTAAASGI KRATVSEGPS ASVMPVKKIG HRSVDSSGET 
TYKKTTSSAL KGAIQLGITH TVGSLSTKPE RDVLMQDFYV VESIFFPSEG SNLTPAHHYN 
DFRFKTYAPV AFRYFRELFG IRPDDYLYSL CSEPLIELSN SGASGSLFYV SSDDEFIIKT 
VQHKEAEFLQ KLLPGYYMNL NQNPRTLLPK FYGLYCVQAG GKNIRIVVMN NLLPRSVKMH 
MKYDLKGSTY KRRASQKERE KTLPTFKDLD FLQDIPDGLF LDADMYSALC KTLQRDCLVL 
QSFKIMDYSL LMSIHNMDHA QREPTSNDTQ YSADTRRPAP QKALYSTAME SIQGEARRGG 
TVETEDHMGG IPARNNKGER LLLYIGIIDI LQSYRFVKKL EHSWKALVHD GDTVSVHRPG 
FYAERFQRFM CNTVFKKIPL KPSPTKKFRS GPSFSRRSGP SGNSCTSQLM ASGEHRAQVT 
TKAEVEPDVH LGRPDVLPQT PPLEEISEGS PVPGPSFSPV VGQPLQILNL SSTLEKLDVA 
ESEFTH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pip5k1a

Associated with

Other Information

Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol 4-phosphate 5-kinase. PubMed ID: 8798574

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. PubMed ID: 9535851

Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. PubMed ID: 10679324

Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. PubMed ID: 18772378

Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis. PubMed ID: 19153220

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. PubMed ID: 20622009

A novel IRS-1-associated protein, DGKzeta regulates GLUT4 translocation in 3T3-L1 adipocytes. PubMed ID: 27739494