Genular: Defining Cellular Identity and Function

Details for: Pirb

Gene ID: 18733

Symbol: Pirb

Ensembl ID: ENSMUSG00000058818

Description: paired Ig-like receptor B

Associated with

Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Adaptive immune response
(GO:0002250)
Amyloid-beta binding
(GO:0001540)
B cell homeostasis
(GO:0001782)
B cell mediated immunity
(GO:0019724)
Cell adhesion molecule binding
(GO:0050839)
Cell surface
(GO:0009986)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoplasm
(GO:0005737)
External side of plasma membrane
(GO:0009897)
Extracellular space
(GO:0005615)
Hla-a specific inhibitory mhc class i receptor activity
(GO:0030107)
Hla-b specific inhibitory mhc class i receptor activity
(GO:0030109)
Immune system process
(GO:0002376)
Inhibitory mhc class i receptor activity
(GO:0032396)
Learning or memory
(GO:0007611)
Membrane
(GO:0016020)
Mhc class ib protein binding
(GO:0023029)
Mhc class ib protein complex binding
(GO:0023025)
Mhc class ib receptor activity
(GO:0032394)
Mhc class i protein binding
(GO:0042288)
Mhc class i receptor activity
(GO:0032393)
Myeloid dendritic cell differentiation
(GO:0043011)
Negative regulation of osteoclast differentiation
(GO:0045671)
Negative regulation of protein metabolic process
(GO:0051248)
Plasma membrane
(GO:0005886)
Positive regulation of long-term synaptic depression
(GO:1900454)
Positive regulation of protein dephosphorylation
(GO:0035307)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein phosphatase 1 binding
(GO:0008157)
Regulation of long-term synaptic potentiation
(GO:1900271)
Sh2 domain binding
(GO:0042169)

Other Information

Proteins

Leukocyte immunoglobulin-like receptor subfamily B member 3

Genular Protein ID: 2043685456

Symbol: LIRB3_MOUSE

Name: Leukocyte immunoglobulin-like receptor subfamily B member 3

UniProtKB Accession Codes:

P97484

Database IDs:

Citations:

PubMed ID: 9054430

Title: Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors.

PubMed ID: 9054430

DOI: 10.1074/jbc.272.11.7320

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 9482905

Title: The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1.

PubMed ID: 9482905

DOI: 10.1073/pnas.95.5.2446

PubMed ID: 10327049

Title: Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1.

PubMed ID: 10327049

DOI: 10.1038/sj.onc.1202552

PubMed ID: 10611342

Title: Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B.

PubMed ID: 10611342

DOI: 10.1073/pnas.96.26.15086

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

Sequence Information:

Length: 841
Mass: 93054
Checksum: 33E9B3C51F44FF3C
Sequence:

MSCTFTALLR LGLTLSLWIP VLTGSLPKPI LRVQPDSVVS RRTKVTFLCE ETIGANEYRL 
YKDGKLYKTV TKNKQKPENK AEFSFSNVDL SNAGQYRCSY STQYKSSGYS DLLELVVTGH 
YWTPSLLAQA SPVVTSGGYV TLQCESWHND HKFILTVEGP QKLSWTQDSQ YNYSTRKYHA 
LFSVGPVTPN QRWICRCYSY DRNRPYVWSP PSESVELLVS GNLQKPTIKA EPGSVITSKR 
AMTIWCQGNL DAEVYFLHNE KSQKTQSTQT LQEPGNKGKF FIPSVTLQHA GQYRCYCYGS 
AGWSQPSDTL ELVVTGIYEY YEPRLSVLPS PVVTAGGNMT LHCASDFPYD KFILTKEDKK 
FGNSLDTEHI SSSGQYRALF IIGPTTPTHT GAFRCYGYYK NAPQLWSVPS ALQQILISGL 
SKKPSLLTHQ GHILDPGMTL TLQCFSDINY DRFALHKVGG ADIMQHSSQQ TDTGFSVANF 
TLGYVSSSTG GQYRCYGAHN LSSEWSASSE PLDILITGQL PLTPSLSVQP NHTVHSGETV 
SLLCWSMDSV DTFILSKEGS AQQPLRLKSK SHDQQSQAEF SMSAVTSHLS GTYRCYGAQD 
SSFYLLSSAS APVELTVSGP IETSTPPPTM SMPLGGLHMY LKALIGVSVA FILFLFIFIF 
ILLRRRHRGK FRKDVQKEKD LQLSSGAEEP ITRKGELQKR PNPAAATQEE SLYASVEDMQ 
TEDGVELNSW TPPEEDPQGE TYAQVKPSRL RKAGHVSPSV MSREQLNTEY EQAEEGQGAN 
NQAAESGESQ DVTYAQLCSR TLRQGAAASP LSQAGEAPEE PSVYATLAAA RPEAVPKDME 
Q

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pirb

Associated with

Other Information

Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors. PubMed ID: 9054430

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. PubMed ID: 9482905

Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1. PubMed ID: 10327049

Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B. PubMed ID: 10611342