Details for: Pou1f1

Gene ID: 18736

Symbol: Pou1f1

Ensembl ID: ENSMUSG00000004842

Description: POU domain, class 1, transcription factor 1

Associated with

  • Adenohypophysis development
    (GO:0021984)
  • B cell differentiation
    (GO:0030183)
  • Cell fate specification
    (GO:0001708)
  • Cell population proliferation
    (GO:0008283)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Cytosol
    (GO:0005829)
  • Determination of adult lifespan
    (GO:0008340)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Inositol trisphosphate biosynthetic process
    (GO:0032959)
  • Lncrna binding
    (GO:0106222)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Pituitary gland development
    (GO:0021983)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of inositol trisphosphate biosynthetic process
    (GO:0032962)
  • Positive regulation of multicellular organism growth
    (GO:0040018)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043567)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatotropin secreting cell development
    (GO:0060133)
  • Somatotropin secreting cell differentiation
    (GO:0060126)
  • Transcription regulator complex
    (GO:0005667)

Other Information

Genular Protein ID: 2540651135

Symbol: PIT1_MOUSE

Name: Pituitary-specific positive transcription factor 1

UniProtKB Accession Codes:

Q00286

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 32 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 1977085

Title: Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

PubMed ID: 1977085

DOI: 10.1038/347528a0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1561093

Title: An alternatively spliced Pit-1 isoform altered in its ability to trans-activate.

PubMed ID: 1561093

DOI: 10.1093/nar/20.6.1355

PubMed ID: 8407911

Title: A thyrotrope-specific variant of Pit-1 transactivates the thyrotropin beta promoter.

PubMed ID: 8407911

DOI: 10.1016/s0021-9258(19)36858-9

Sequence Information:

  • Length: 291
  • Mass: 32885
  • Checksum: E2C265F4353E84C5
  • Sequence:
    • MSCQSFTSAD TFITLNSDAS AALPLRMHHS AAECLPASNH ATNVMSTATG LHYSVPSCHY 
GNQPSTYGVM AGSLTPCLYK FPDHTLSHGF PPLHQPLLAE DPAASEFKQE LRRKSKLVEE 
PIDMDSPEIR ELEQFANEFK VRRIKLGYTQ TNVGEALAAV HGSEFSQTTI CRFENLQLSF 
KNACKLKAIL SKWLEEAEQV GALYNEKVGA NERKRKRRTT ISVAAKDALE RHFGEHSKPS 
SQEIMRMAEE LNLEKEVVRV WFCNRRQREK RVKTSLNQSL FSISKEHLEC R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.