Details for: Pitx3

Gene ID: 18742

Symbol: Pitx3

Ensembl ID: ENSMUSG00000025229

Description: paired-like homeodomain transcription factor 3

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dopaminergic neuron differentiation
    (GO:0071542)
  • Lens development in camera-type eye
    (GO:0002088)
  • Lens fiber cell differentiation
    (GO:0070306)
  • Lens morphogenesis in camera-type eye
    (GO:0002089)
  • Locomotory behavior
    (GO:0007626)
  • Midbrain development
    (GO:0030901)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of gliogenesis
    (GO:0014014)
  • Negative regulation of neurogenesis
    (GO:0050768)
  • Neuron development
    (GO:0048666)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell proliferation in midbrain
    (GO:1904935)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Other Information

Genular Protein ID: 1185977496

Symbol: PITX3_MOUSE

Name: Pituitary homeobox 3

UniProtKB Accession Codes:

O35160 Q0VB03

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 9328475

Title: Isolation of a new homeobox gene belonging to the Pitx/Rieg family: expression during lens development and mapping to the aphakia region on mouse chromosome 19.

PubMed ID: 9328475

DOI: 10.1093/hmg/6.12.2109

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9620774

Title: A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD.

PubMed ID: 9620774

DOI: 10.1038/527

PubMed ID: 15950611

Title: Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development.

PubMed ID: 15950611

DOI: 10.1016/j.ydbio.2005.03.028

PubMed ID: 17184956

Title: Induction of tyrosine hydroxylase expression by the transcription factor Pitx3.

PubMed ID: 17184956

DOI: 10.1016/j.ijdevneu.2006.11.003

PubMed ID: 19334279

Title: Pitx3 controls multiple aspects of lens development.

PubMed ID: 19334279

DOI: 10.1002/dvdy.21924

PubMed ID: 19144721

Title: Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression.

PubMed ID: 19144721

DOI: 10.1242/dev.029769

PubMed ID: 19007884

Title: Homeodomain protein Pitx3 maintains the mitotic activity of lens epithelial cells.

PubMed ID: 19007884

DOI: 10.1016/j.mod.2008.10.007

Sequence Information:

  • Length: 302
  • Mass: 31715
  • Checksum: EB6EF6863B349264
  • Sequence:
    • MEFGLLGEAE ARSPALSLSD AGTPHPPLPE HGCKGQEHSD SEKASASLPG GSPEDGSLKK 
KQRRQRTHFT SQQLQELEAT FQRNRYPDMS TREEIAVWTN LTEARVRVWF KNRRAKWRKR 
ERSQQAELCK GGFAAPLGGL VPPYEEVYPG YSYGNWPPKA LAPPLAAKTF PFAFNSVNVG 
PLASQPVFSP PSSIAASMVP SAAAAPGTVP GPGALQGLGG APPGLAPAAV SSGAVSCPYA 
SAAAAAAAAA SSPYVYRDPC NSSLASLRLK AKQHASFSYP AVPGPPPAAN LSPCQYAVER 
PV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.