Genular: Defining Cellular Identity and Function

Details for: Pkm

Gene ID: 18746

Symbol: Pkm

Ensembl ID: ENSMUSG00000032294

Description: pyruvate kinase, muscle

Associated with

Glucose metabolism
(R-MMU-70326)
Glycolysis
(R-MMU-70171)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Neutrophil degranulation
(R-MMU-6798695)
Adp binding
(GO:0043531)
Animal organ regeneration
(GO:0031100)
Atp binding
(GO:0005524)
Canonical glycolysis
(GO:0061621)
Catalytic activity
(GO:0003824)
Cellular response to insulin stimulus
(GO:0032869)
Cilium
(GO:0005929)
Collagen-containing extracellular matrix
(GO:0062023)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Glucose metabolic process
(GO:0006006)
Glycolytic process
(GO:0006096)
Identical protein binding
(GO:0042802)
Kinase activity
(GO:0016301)
Liver development
(GO:0001889)
Magnesium ion binding
(GO:0000287)
Metabolic process
(GO:0008152)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Mrna binding
(GO:0003729)
Myelin sheath
(GO:0043209)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Positive regulation of cytoplasmic translation
(GO:2000767)
Positive regulation of sprouting angiogenesis
(GO:1903672)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Potassium ion binding
(GO:0030955)
Programmed cell death
(GO:0012501)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein homodimerization activity
(GO:0042803)
Protein homotetramerization
(GO:0051289)
Protein serine/threonine kinase activity
(GO:0004674)
Protein tetramerization
(GO:0051262)
Protein tyrosine kinase activity
(GO:0004713)
Pyruvate biosynthetic process
(GO:0042866)
Pyruvate kinase activity
(GO:0004743)
Pyruvate kinase complex
(GO:1902912)
Pyruvate metabolic process
(GO:0006090)
Regulation of translation
(GO:0006417)
Rough endoplasmic reticulum
(GO:0005791)
Skeletal muscle tissue regeneration
(GO:0043403)
Thyroid hormone binding
(GO:0070324)
Transcription coactivator activity
(GO:0003713)
Transferase activity
(GO:0016740)

Other Information

Proteins

Pyruvate kinase PKM

Genular Protein ID: 2605735080

Symbol: KPYM_MOUSE

Name: Pyruvate kinase PKM

UniProtKB Accession Codes:

P52480 Q3TBV8 Q3TBW5 Q3TC59 Q3U1X3 Q3U5P6 Q4VC20 Q64484 Q91YI8 Q9CWB1

Database IDs:

Citations:

PubMed ID: 7612666

Title: Molecular cloning of the complementary DNA for the mouse pyruvate kinase M-2 gene whose expression is dependent upon cell differentiation.

PubMed ID: 7612666

DOI: 10.1016/0167-4889(95)00071-y

PubMed ID: 9545585

Title: Gene expression of mouse M1 and M2 pyruvate kinase isoenzymes correlates with differential poly(A) tract extension of their mRNAs during the development of spermatogenesis.

PubMed ID: 9545585

DOI: 10.1016/s0167-4781(97)00195-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 18191611

Title: Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription.

PubMed ID: 18191611

DOI: 10.1016/j.biocel.2007.11.009

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 28575669

Title: The mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity.

PubMed ID: 28575669

DOI: 10.1016/j.cell.2017.05.022

PubMed ID: 29996098

Title: The circadian clock controls immune checkpoint pathway in sepsis.

PubMed ID: 29996098

DOI: 10.1016/j.celrep.2018.06.026

Sequence Information:

Length: 531
Mass: 57845
Checksum: 34CBBC01BC0C047D
Sequence:

MPKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSAPI TARNTGIICT IGPASRSVEM 
LKEMIKSGMN VARLNFSHGT HEYHAETIKN VREATESFAS DPILYRPVAV ALDTKGPEIR 
TGLIKGSGTA EVELKKGATL KITLDNAYME KCDENILWLD YKNICKVVEV GSKIYVDDGL 
ISLQVKEKGA DFLVTEVENG GSLGSKKGVN LPGAAVDLPA VSEKDIQDLK FGVEQDVDMV 
FASFIRKAAD VHEVRKVLGE KGKNIKIISK IENHEGVRRF DEILEASDGI MVARGDLGIE 
IPAEKVFLAQ KMMIGRCNRA GKPVICATQM LESMIKKPRP TRAEGSDVAN AVLDGADCIM 
LSGETAKGDY PLEAVRMQHL IAREAEAAIY HLQLFEELRR LAPITSDPTE AAAVGAVEAS 
FKCCSGAIIV LTKSGRSAHQ VARYRPRAPI IAVTRNPQTA RQAHLYRGIF PVLCKDAVLN 
AWAEDVDLRV NLAMDVGKAR GFFKKGDVVI VLTGWRPGSG FTNTMRVVPV P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pkm

Associated with

Other Information

Molecular cloning of the complementary DNA for the mouse pyruvate kinase M-2 gene whose expression is dependent upon cell differentiation. PubMed ID: 7612666

Gene expression of mouse M1 and M2 pyruvate kinase isoenzymes correlates with differential poly(A) tract extension of their mRNAs during the development of spermatogenesis. PubMed ID: 9545585

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. PubMed ID: 16139798

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. PubMed ID: 18191611

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

The mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity. PubMed ID: 28575669

The circadian clock controls immune checkpoint pathway in sepsis. PubMed ID: 29996098