Genular: Defining Cellular Identity and Function

Details for: Prkaca

Gene ID: 18747

Symbol: Prkaca

Ensembl ID: ENSMUSG00000005469

Description: protein kinase, cAMP dependent, catalytic, alpha

Associated with

Activation of nmda receptors and postsynaptic events
(R-MMU-442755)
Adaptive immune system
(R-MMU-1280218)
Anchoring of the basal body to the plasma membrane
(R-MMU-5620912)
Aquaporin-mediated transport
(R-MMU-445717)
Aurka activation by tpx2
(R-MMU-8854518)
Axon guidance
(R-MMU-422475)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Ca-dependent events
(R-MMU-111996)
Calmodulin induced events
(R-MMU-111933)
Cam pathway
(R-MMU-111997)
Cardiac conduction
(R-MMU-5576891)
Cd209 (dc-sign) signaling
(R-MMU-5621575)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Centrosome maturation
(R-MMU-380287)
Cilium assembly
(R-MMU-5617833)
Creb1 phosphorylation through the activation of adenylate cyclase
(R-MMU-442720)
Cytokine signaling in immune system
(R-MMU-1280215)
Dag and ip3 signaling
(R-MMU-1489509)
Darpp-32 events
(R-MMU-180024)
Developmental biology
(R-MMU-1266738)
Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
G-protein mediated events
(R-MMU-112040)
G2/m transition
(R-MMU-69275)
G alpha (i) signalling events
(R-MMU-418594)
G alpha (s) signalling events
(R-MMU-418555)
Gli3 is processed to gli3r by the proteasome
(R-MMU-5610785)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-MMU-381676)
Glucagon signaling in metabolic regulation
(R-MMU-163359)
Gpcr downstream signalling
(R-MMU-388396)
Gper1 signaling
(R-MMU-9634597)
Hdl assembly
(R-MMU-8963896)
Hedgehog 'off' state
(R-MMU-5610787)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Integration of energy metabolism
(R-MMU-163685)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-MMU-512988)
Intracellular signaling by second messengers
(R-MMU-9006925)
Ion homeostasis
(R-MMU-5578775)
Loss of nlp from mitotic centrosomes
(R-MMU-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-MMU-380284)
Mapk6/mapk4 signaling
(R-MMU-5687128)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism
(R-MMU-1430728)
Metabolism of proteins
(R-MMU-392499)
Mitochondrial protein degradation
(R-MMU-9837999)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic prometaphase
(R-MMU-68877)
M phase
(R-MMU-68886)
Muscle contraction
(R-MMU-397014)
Nervous system development
(R-MMU-9675108)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Opioid signalling
(R-MMU-111885)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Pka-mediated phosphorylation of creb
(R-MMU-111931)
Pka activation
(R-MMU-163615)
Pka activation in glucagon signalling
(R-MMU-164378)
Plasma lipoprotein assembly
(R-MMU-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plc beta mediated events
(R-MMU-112043)
Post nmda receptor activation events
(R-MMU-438064)
Rap1 signalling
(R-MMU-392517)
Recruitment of mitotic centrosome proteins and complexes
(R-MMU-380270)
Recruitment of numa to mitotic centrosomes
(R-MMU-380320)
Regulation of insulin secretion
(R-MMU-422356)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Ret signaling
(R-MMU-8853659)
Signaling by gpcr
(R-MMU-372790)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by interleukins
(R-MMU-449147)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Transmission across chemical synapses
(R-MMU-112315)
Transport of small molecules
(R-MMU-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-MMU-432040)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Amp-activated protein kinase activity
(GO:0004679)
Atp binding
(GO:0005524)
Camp-dependent protein kinase activity
(GO:0004691)
Kinase activity
(GO:0016301)
Magnesium ion binding
(GO:0000287)
Manganese ion binding
(GO:0030145)
Nucleotide binding
(GO:0000166)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein serine/threonine/tyrosine kinase activity
(GO:0004712)
Protein serine/threonine kinase activity
(GO:0004674)
Transferase activity
(GO:0016740)

Other Information

Proteins

cAMP-dependent protein kinase catalytic subunit alpha

Genular Protein ID: 2160290410

Symbol: KAPCA_MOUSE

Name: cAMP-dependent protein kinase catalytic subunit alpha

UniProtKB Accession Codes:

P05132 Q9JID0

Database IDs:

Citations:

PubMed ID: 2833513

Title: Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase.

PubMed ID: 2833513

DOI: 10.1016/s0021-9258(18)60627-1

PubMed ID: 3456589

Title: Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase.

PubMed ID: 3456589

DOI: 10.1073/pnas.83.5.1300

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10982398

Title: The unique catalytic subunit of sperm cAMP-dependent protein kinase is the product of an alternative C-alpha mRNA expressed specifically in spermatogenic cells.

PubMed ID: 10982398

DOI: 10.1091/mbc.11.9.3031

PubMed ID: 8395513

Title: Identification of phosphorylation sites in the recombinant catalytic subunit of cAMP-dependent protein kinase.

PubMed ID: 8395513

DOI: 10.1016/s0021-9258(17)46675-0

PubMed ID: 9707564

Title: Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase.

PubMed ID: 9707564

DOI: 10.1073/pnas.95.17.9849

PubMed ID: 10805756

Title: Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer.

PubMed ID: 10805756

DOI: 10.1128/mcb.20.11.4149-4158.2000

PubMed ID: 11141074

Title: Influence of myristoylation, phosphorylation, and deamidation on the structural behavior of the N-terminus of the catalytic subunit of cAMP-dependent protein kinase.

PubMed ID: 11141074

DOI: 10.1021/bi0021277

PubMed ID: 11875122

Title: Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction.

PubMed ID: 11875122

DOI: 10.1210/mend.16.3.0793

PubMed ID: 15340140

Title: Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility.

PubMed ID: 15340140

DOI: 10.1073/pnas.0405580101

PubMed ID: 18367160

Title: Developmentally acquired PKA localisation in mouse oocytes and embryos.

PubMed ID: 18367160

DOI: 10.1016/j.ydbio.2008.01.045

PubMed ID: 19223768

Title: Protein kinase A regulates resumption of meiosis by phosphorylation of Cdc25B in mammalian oocytes.

PubMed ID: 19223768

DOI: 10.4161/cc.8.4.7846

PubMed ID: 19560455

Title: Phosphorylation and consequent stimulation of the tyrosine kinase c-Abl by PKA in mouse spermatozoa; its implications during capacitation.

PubMed ID: 19560455

DOI: 10.1016/j.ydbio.2009.06.022

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21866565

Title: Direct modulation of the protein kinase A catalytic subunit alpha by growth factor receptor tyrosine kinases.

PubMed ID: 21866565

DOI: 10.1002/jcb.23325

PubMed ID: 27105888

Title: A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation.

PubMed ID: 27105888

DOI: 10.1096/fj.201500136r

PubMed ID: 33886552

Title: Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.

PubMed ID: 33886552

DOI: 10.1371/journal.pbio.3001191

PubMed ID: 1862342

Title: Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.

PubMed ID: 1862342

DOI: 10.1126/science.1862342

PubMed ID: 8443157

Title: Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor.

PubMed ID: 8443157

DOI: 10.1021/bi00060a005

PubMed ID: 9109651

Title: Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine.

PubMed ID: 9109651

DOI: 10.1021/bi961947+

PubMed ID: 9261084

Title: A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility.

PubMed ID: 9261084

DOI: 10.1016/s0969-2126(97)00246-3

PubMed ID: 17889648

Title: PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation.

PubMed ID: 17889648

DOI: 10.1016/j.cell.2007.07.018

PubMed ID: 17932298

Title: PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.

PubMed ID: 17932298

DOI: 10.1126/science.1146447

PubMed ID: 19122195

Title: Contribution of non-catalytic core residues to activity and regulation in protein kinase A.

PubMed ID: 19122195

DOI: 10.1074/jbc.m805862200

PubMed ID: 19748511

Title: Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures.

PubMed ID: 19748511

DOI: 10.1016/j.jmb.2009.09.014

PubMed ID: 20890288

Title: Dynamics connect substrate recognition to catalysis in protein kinase A.

PubMed ID: 20890288

DOI: 10.1038/nchembio.452

PubMed ID: 22323819

Title: Structure and allostery of the PKA RIIbeta tetrameric holoenzyme.

PubMed ID: 22323819

DOI: 10.1126/science.1213979

Sequence Information:

Length: 351
Mass: 40571
Checksum: 02F85D66EB21A1FA
Sequence:

MGNAAAAKKG SEQESVKEFL AKAKEDFLKK WETPSQNTAQ LDQFDRIKTL GTGSFGRVML 
VKHKESGNHY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVKLEFS FKDNSNLYMV 
MEYVAGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDQQGY 
IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF 
ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVN DIKNHKWFAT 
TDWIAIYQRK VEAPFIPKFK GPGDTSNFDD YEEEEIRVSI NEKCGKEFTE F

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prkaca

Associated with

Other Information

Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase. PubMed ID: 2833513

Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase. PubMed ID: 3456589

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The unique catalytic subunit of sperm cAMP-dependent protein kinase is the product of an alternative C-alpha mRNA expressed specifically in spermatogenic cells. PubMed ID: 10982398

Identification of phosphorylation sites in the recombinant catalytic subunit of cAMP-dependent protein kinase. PubMed ID: 8395513

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. PubMed ID: 9707564

Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. PubMed ID: 10805756

Influence of myristoylation, phosphorylation, and deamidation on the structural behavior of the N-terminus of the catalytic subunit of cAMP-dependent protein kinase. PubMed ID: 11141074

Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction. PubMed ID: 11875122

Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility. PubMed ID: 15340140

Developmentally acquired PKA localisation in mouse oocytes and embryos. PubMed ID: 18367160

Protein kinase A regulates resumption of meiosis by phosphorylation of Cdc25B in mammalian oocytes. PubMed ID: 19223768

Phosphorylation and consequent stimulation of the tyrosine kinase c-Abl by PKA in mouse spermatozoa; its implications during capacitation. PubMed ID: 19560455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Direct modulation of the protein kinase A catalytic subunit alpha by growth factor receptor tyrosine kinases. PubMed ID: 21866565

A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation. PubMed ID: 27105888

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits. PubMed ID: 33886552

Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. PubMed ID: 1862342

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. PubMed ID: 8443157

Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. PubMed ID: 9109651

A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility. PubMed ID: 9261084

PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. PubMed ID: 17889648

PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. PubMed ID: 17932298

Contribution of non-catalytic core residues to activity and regulation in protein kinase A. PubMed ID: 19122195

Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures. PubMed ID: 19748511

Dynamics connect substrate recognition to catalysis in protein kinase A. PubMed ID: 20890288

Structure and allostery of the PKA RIIbeta tetrameric holoenzyme. PubMed ID: 22323819