Genular: Defining Cellular Identity and Function

Details for: Prkacb

Gene ID: 18749

Symbol: Prkacb

Ensembl ID: ENSMUSG00000005034

Description: protein kinase, cAMP dependent, catalytic, beta

Associated with

Activation of nmda receptors and postsynaptic events
(R-MMU-442755)
Adaptive immune system
(R-MMU-1280218)
Aquaporin-mediated transport
(R-MMU-445717)
Axon guidance
(R-MMU-422475)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Ca-dependent events
(R-MMU-111996)
Calmodulin induced events
(R-MMU-111933)
Cam pathway
(R-MMU-111997)
Cd209 (dc-sign) signaling
(R-MMU-5621575)
Creb1 phosphorylation through the activation of adenylate cyclase
(R-MMU-442720)
Dag and ip3 signaling
(R-MMU-1489509)
Darpp-32 events
(R-MMU-180024)
Developmental biology
(R-MMU-1266738)
Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
G-protein mediated events
(R-MMU-112040)
G alpha (i) signalling events
(R-MMU-418594)
G alpha (s) signalling events
(R-MMU-418555)
Gli3 is processed to gli3r by the proteasome
(R-MMU-5610785)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-MMU-381676)
Glucagon signaling in metabolic regulation
(R-MMU-163359)
Gpcr downstream signalling
(R-MMU-388396)
Gper1 signaling
(R-MMU-9634597)
Hdl assembly
(R-MMU-8963896)
Hedgehog 'off' state
(R-MMU-5610787)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Integration of energy metabolism
(R-MMU-163685)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk6/mapk4 signaling
(R-MMU-5687128)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism
(R-MMU-1430728)
Nervous system development
(R-MMU-9675108)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Opioid signalling
(R-MMU-111885)
Pka-mediated phosphorylation of creb
(R-MMU-111931)
Pka activation
(R-MMU-163615)
Pka activation in glucagon signalling
(R-MMU-164378)
Plasma lipoprotein assembly
(R-MMU-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plc beta mediated events
(R-MMU-112043)
Post nmda receptor activation events
(R-MMU-438064)
Rap1 signalling
(R-MMU-392517)
Regulation of insulin secretion
(R-MMU-422356)
Ret signaling
(R-MMU-8853659)
Signaling by gpcr
(R-MMU-372790)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Transmission across chemical synapses
(R-MMU-112315)
Transport of small molecules
(R-MMU-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-MMU-432040)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Amp-activated protein kinase activity
(GO:0004679)
Atp binding
(GO:0005524)
Camp-dependent protein kinase activity
(GO:0004691)
Camp-dependent protein kinase complex
(GO:0005952)
Centrosome
(GO:0005813)
Ciliary base
(GO:0097546)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Kinase activity
(GO:0016301)
Magnesium ion binding
(GO:0000287)
Membrane
(GO:0016020)
Negative regulation of meiotic cell cycle
(GO:0051447)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Negative regulation of torc1 signaling
(GO:1904262)
Neural tube closure
(GO:0001843)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Protein kinase activity
(GO:0004672)
Protein kinase a signaling
(GO:0010737)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of protein processing
(GO:0070613)
Transferase activity
(GO:0016740)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

cAMP-dependent protein kinase catalytic subunit beta

Genular Protein ID: 1443831469

Symbol: KAPCB_MOUSE

Name: cAMP-dependent protein kinase catalytic subunit beta

UniProtKB Accession Codes:

P68181 P05206 Q3TQH5 Q3UDD0 Q3UTH5

Database IDs:

Citations:

PubMed ID: 3023318

Title: Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase.

PubMed ID: 3023318

DOI: 10.1016/s0021-9258(18)66717-1

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2833513

Title: Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase.

PubMed ID: 2833513

DOI: 10.1016/s0021-9258(18)60627-1

PubMed ID: 9368018

Title: Two novel brain-specific splice variants of the murine Cbeta gene of cAMP-dependent protein kinase.

PubMed ID: 9368018

DOI: 10.1074/jbc.272.47.29560

PubMed ID: 12106288

Title: A collection of cDNA clones with specific expression patterns in mouse brain.

PubMed ID: 12106288

DOI: 10.1111/j.1460-9568.1990.tb00460.x

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 351
Mass: 40708
Checksum: EBAC9B8041DF9F47
Sequence:

MGNTAIAKKG SEVESVKEFL AKAKEDFLRK WENPPPSNAG LEDFERKKTL GTGSFGRVML 
VKHKATEQYY AMKILDKQKV VKLKQIEHTL NEKRILQAVE FPFLVRLEYS FKDNSNLYMV 
MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDHQGY 
IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF 
ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVS DIKTHKWFAT 
TDWIAIYQRK VEAPFIPKFR GSGDTSNFDD YEEEEIRVSI TEKCGKEFCE F

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prkacb

Associated with

Other Information

Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase. PubMed ID: 3023318

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase. PubMed ID: 2833513

Two novel brain-specific splice variants of the murine Cbeta gene of cAMP-dependent protein kinase. PubMed ID: 9368018

A collection of cDNA clones with specific expression patterns in mouse brain. PubMed ID: 12106288

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079