Prkcd | ENSMUSG00000021948 | NCBI 18753

Details for: Prkcd

Gene ID: 18753

Symbol: Prkcd

Ensembl ID: ENSMUSG00000021948

Description: protein kinase C, delta

Associated with

Apoptosis
(R-MMU-109581)
Apoptotic cleavage of cellular proteins
(R-MMU-111465)
Apoptotic execution phase
(R-MMU-75153)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Ca-dependent events
(R-MMU-111996)
Calmodulin induced events
(R-MMU-111933)
Cam pathway
(R-MMU-111997)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cytokine signaling in immune system
(R-MMU-1280215)
Dag and ip3 signaling
(R-MMU-1489509)
Effects of pip2 hydrolysis
(R-MMU-114508)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-MMU-2029480)
G-protein mediated events
(R-MMU-112040)
G alpha (i) signalling events
(R-MMU-418594)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Hemostasis
(R-MMU-109582)
Hur (elavl1) binds and stabilizes mrna
(R-MMU-450520)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interferon gamma signaling
(R-MMU-877300)
Interferon signaling
(R-MMU-913531)
Intracellular signaling by second messengers
(R-MMU-9006925)
Metabolism of rna
(R-MMU-8953854)
Neutrophil degranulation
(R-MMU-6798695)
Opioid signalling
(R-MMU-111885)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Plc beta mediated events
(R-MMU-112043)
Programmed cell death
(R-MMU-5357801)
Regulation of mrna stability by proteins that bind au-rich elements
(R-MMU-450531)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate nadph oxidases
(R-MMU-5668599)
Role of phospholipids in phagocytosis
(R-MMU-2029485)
Shc1 events in erbb2 signaling
(R-MMU-1250196)
Signaling by erbb2
(R-MMU-1227986)
Signaling by gpcr
(R-MMU-372790)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegfr2 mediated cell proliferation
(R-MMU-5218921)
Activation of protein kinase activity
(GO:0032147)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
B cell proliferation
(GO:0042100)
Cell chemotaxis
(GO:0060326)
Cell cycle
(GO:0007049)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to uv
(GO:0034644)
Collagen metabolic process
(GO:0032963)
Defense response to bacterium
(GO:0042742)
Diacylglycerol-dependent, calcium-independent serine/threonine kinase activity
(GO:0004699)
Diacylglycerol-dependent serine/threonine kinase activity
(GO:0004697)
Dna damage response
(GO:0006974)
Enzyme activator activity
(GO:0008047)
Enzyme binding
(GO:0019899)
Immunoglobulin mediated immune response
(GO:0016064)
Insulin receptor substrate binding
(GO:0043560)
Interleukin-10 production
(GO:0032613)
Interleukin-12 production
(GO:0032615)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Metal ion binding
(GO:0046872)
Negative regulation of actin filament polymerization
(GO:0030837)
Negative regulation of filopodium assembly
(GO:0051490)
Negative regulation of glial cell apoptotic process
(GO:0034351)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of peptidyl-tyrosine phosphorylation
(GO:0050732)
Neutrophil activation
(GO:0042119)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nucleotide binding
(GO:0000166)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phosphorylation
(GO:0016310)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of endodeoxyribonuclease activity
(GO:0032079)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of protein dephosphorylation
(GO:0035307)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of superoxide anion generation
(GO:0032930)
Post-translational protein modification
(GO:0043687)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of phosphorylation
(GO:0042325)
Response to oxidative stress
(GO:0006979)
Termination of signal transduction
(GO:0023021)
Tir domain binding
(GO:0070976)
Transferase activity
(GO:0016740)

Other Information

Proteins

Tyrosine-protein kinase PRKCD
Q3TGE4_MOUSE

Genular Protein ID: 461143561

Symbol: KPCD_MOUSE

Name: Tyrosine-protein kinase PRKCD

UniProtKB Accession Codes:

P28867 Q91V85 Q9Z333

Database IDs:

Citations:

PubMed ID: 1868068

Title: Mouse protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein.

PubMed ID: 1868068

DOI: 10.1021/bi00246a008

PubMed ID: 1765103

Title: Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta.

PubMed ID: 1765103

DOI: 10.1111/j.1432-1033.1991.tb16453.x

PubMed ID: 11558579

Title: Novel protein kinase C delta isoform insensitive to caspase-3.

PubMed ID: 11558579

DOI: 10.1248/bpb.24.973

PubMed ID: 9054438

Title: A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation.

PubMed ID: 9054438

DOI: 10.1074/jbc.272.11.7381

PubMed ID: 9705322

Title: A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein.

PubMed ID: 9705322

DOI: 10.1074/jbc.273.34.21834

PubMed ID: 11976686

Title: Protein kinase Cdelta controls self-antigen-induced B-cell tolerance.

PubMed ID: 11976686

DOI: 10.1038/416860a

PubMed ID: 9748166

Title: Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.

PubMed ID: 9748166

DOI: 10.1126/science.281.5385.2042

PubMed ID: 11976687

Title: Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta.

PubMed ID: 11976687

DOI: 10.1038/416865a

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 18025218

Title: A critical role of protein kinase C delta activation loop phosphorylation in formyl-methionyl-leucyl-phenylalanine-induced phosphorylation of p47(phox) and rapid activation of nicotinamide adenine dinucleotide phosphate oxidase.

PubMed ID: 18025218

DOI: 10.4049/jimmunol.179.11.7720

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19917613

Title: The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint.

PubMed ID: 19917613

DOI: 10.1074/jbc.m109.055392

PubMed ID: 22265677

Title: Syk kinase-coupled C-type lectin receptors engage protein kinase C-delta to elicit Card9 adaptor-mediated innate immunity.

PubMed ID: 22265677

DOI: 10.1016/j.immuni.2011.11.015

PubMed ID: 7781068

Title: Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester.

PubMed ID: 7781068

DOI: 10.1016/0092-8674(95)90011-x

Sequence Information:

Length: 674
Mass: 77547
Checksum: 6E9F753348F03D59
Sequence:

MAPFLRISFN SYELGSLQVE DEASQPFCAV KMKEALSTER GKTLVQKKPT MYPEWKTTFD 
AHIYEGRVIQ IVLMRAAEDP VSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMCVQY 
FLEDGDCKQS MRSEEEAKFP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKEFVW 
GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TATNSRDTIF QKERFNIDMP HRFKVYNYMS 
PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCREKVANLC GINQKLLAEA LNQVTQRSSR 
KLDTTESVGI YQGFEKKPEV SGSDILDNNG TYGKIWEGST RCTLENFTFQ KVLGKGSFGK 
VLLAELKGKD KYFAIKCLKK DVVLIDDDVE CTMVEKRVLA LAWESPFLTH LICTFQTKDH 
LFFVMEFLNG GDLMFHIQDK GRFELYRATF YAAEIICGLQ FLHSKGIIYR DLKLDNVMLD 
RDGHIKIADF GMCKENIFGE GRASTFCGTP DYIAPEILQG LKYSFSVDWW SFGVLLYEML 
IGQSPFHGDD EDELFESIRV DTPHYPRWIT KESKDIMEKL FERDPDKRLG VTGNIRIHPF 
FKTINWSLLE KRKVEPPFKP KVKSPSDYSN FDPEFLNEKP QLSFSDKNLI DSMDQEAFHG 
FSFVNPKFEQ FLDI

Genular Protein ID: 531585377

Symbol: Q3TGE4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TGE4

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 674
Mass: 77560
Checksum: 90D77F36458023F4
Sequence:

MAPFLRISFN SYELGSLQVE DEASQPFCAV KMKEALSTER GKTLVQKKPT MYPEWKTTFD 
AHIYEGRVIQ IVLMRAAEDP VSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMCVQY 
FLEDGDCKQS MRSEEEAKFP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKEFVW 
GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TATNSRDTIF QKERFNIDMP HRFKVYNYMS 
PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCRVKVANLC GINQKLLAEA LNQVTQRSSR 
KLDTTESVGI YQGFEKKPEV SGSDILDNNG TYGKIWEGST RCTLENFTFQ KVLGKGSFGK 
VLLAELKGKD KYFAIKCLKK DVVLIDDDVE CTMVEKRVLA LAWESPFLTH LICTFQTKDH 
LFFVMEFLNG GDLMFHIQDK GRFELYRATF YAAEIICGLQ FLHSKGIIYR DLKLDNVMLD 
RDGHIKIADF GMCKENIFGE GRASTFCGTP DYIAPEILQG LKYSFSVDWW SFGVLRYEML 
IGQSPFHGDD EDELFESIRV DTPHYPRWIT KESKDIMEKL FERDPDKRLG VTGNIRIHPF 
FKTINWSLLE KRKVEPPFKP KVKSPSDYSN FDPEFLNEKP QLSFSDKNLI DSMDQEAFHG 
FSFVNPKFEQ FLDI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prkcd

Associated with

Other Information

Mouse protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein. PubMed ID: 1868068

Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta. PubMed ID: 1765103

Novel protein kinase C delta isoform insensitive to caspase-3. PubMed ID: 11558579

A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation. PubMed ID: 9054438

A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein. PubMed ID: 9705322

Protein kinase Cdelta controls self-antigen-induced B-cell tolerance. PubMed ID: 11976686

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. PubMed ID: 9748166

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. PubMed ID: 11976687

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

A critical role of protein kinase C delta activation loop phosphorylation in formyl-methionyl-leucyl-phenylalanine-induced phosphorylation of p47(phox) and rapid activation of nicotinamide adenine dinucleotide phosphate oxidase. PubMed ID: 18025218

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint. PubMed ID: 19917613

Syk kinase-coupled C-type lectin receptors engage protein kinase C-delta to elicit Card9 adaptor-mediated innate immunity. PubMed ID: 22265677

Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester. PubMed ID: 7781068

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073