Genular: Defining Cellular Identity and Function

Details for: Prkch

Gene ID: 18755

Symbol: Prkch

Ensembl ID: ENSMUSG00000021108

Description: protein kinase C, eta

Associated with

Effects of pip2 hydrolysis
(R-MMU-114508)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Hemostasis
(R-MMU-109582)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Atp binding
(GO:0005524)
Cell-cell junction
(GO:0005911)
Cell differentiation
(GO:0030154)
Cellular response to amino acid starvation
(GO:0034198)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Diacylglycerol-dependent, calcium-independent serine/threonine kinase activity
(GO:0004699)
Diacylglycerol-dependent serine/threonine kinase activity
(GO:0004697)
Enzyme binding
(GO:0019899)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Metal ion binding
(GO:0046872)
Negative regulation of glial cell apoptotic process
(GO:0034351)
Negative regulation of protein serine/threonine kinase activity
(GO:0071901)
Negative regulation of translation
(GO:0017148)
Nucleotide binding
(GO:0000166)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of b cell receptor signaling pathway
(GO:0050861)
Positive regulation of glial cell proliferation
(GO:0060252)
Positive regulation of keratinocyte differentiation
(GO:0045618)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of translation in response to stress
(GO:0032056)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase c signaling
(GO:0070528)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine/threonine kinase binding
(GO:0120283)
Protein serine/threonine kinase inhibitor activity
(GO:0030291)
Regulation of bicellular tight junction assembly
(GO:2000810)
Small gtpase binding
(GO:0031267)
Transferase activity
(GO:0016740)
Translation regulator activity
(GO:0045182)

Other Information

Proteins

Protein kinase C eta type
Q3UKY1_MOUSE

Genular Protein ID: 764194260

Symbol: KPCL_MOUSE

Name: Protein kinase C eta type

UniProtKB Accession Codes:

P23298 Q8K2K8

Database IDs:

Citations:

PubMed ID: 2266135

Title: A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin.

PubMed ID: 2266135

DOI: 10.1016/s0021-9258(18)45723-7

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11106751

Title: A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation.

PubMed ID: 11106751

DOI: 10.1016/s1097-2765(00)00110-6

PubMed ID: 18780722

Title: PKC eta directs induction of IRF-4 expression and Ig kappa gene rearrangement in pre-BCR signaling pathway.

PubMed ID: 18780722

DOI: 10.1093/intimm/dxn101

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21346190

Title: Direct binding of RalA to PKC? and its crucial role in morphological change during keratinocyte differentiation.

PubMed ID: 21346190

DOI: 10.1091/mbc.e10-09-0754

Sequence Information:

Length: 683
Mass: 77919
Checksum: 50454A6AE1900AD3
Sequence:

MSSGTMKFNG YLRVRIGEAV GLQPTRWSLR HSLFKKGHQL LDPYLTVSVD QVRVGQTSTK 
QKTNKPTYNE EFCANVTDGG HLELAVFHET PLGYDHFVAN CTLQFQELLR TAGTSDTFEG 
WVDLEPEGKV FVVITLTGSF TEATLQRDRI FKHFTRKRQR AMRRRVHQVN GHKFMATYLR 
QPTYCSHCRE FIWGVFGKQG YQCQVCTCVV HKRCHHLIVT ACTCQNNINK VDAKIAEQRF 
GINIPHKFNV HNYKVPTFCD HCGSLLWGIM RQGLQCKICK MNVHIRCQAN VAPNCGVNAV 
ELAKTLAGMG LQPGNISPTS KLISRSTLRR QGKEGSKEGN GIGVNSSSRF GIDNFEFIRV 
LGKGSFGKVM LARIKETGEL YAVKVLKKDV ILQDDDVECT MTEKRILSLA RNHPFLTQLF 
CCFQTPDRLF FVMEFVNGGD LMFHIQKSRR FDEARARFYA AEIISALMFL HEKGIIYRDL 
KLDNVLLDHE GHCKLADFGM CKEGICNGVT TATFCGTPDY IAPEILQEML YGPAVDWWAM 
GVLLYEMLCG HAPFEAENED DLFEAILNDE VVYPTWLHED ATGILKSFMT KNPTMRLGSL 
TQGGEHEILR HPFFKEIDWA QLNHRQLEPP FRPRIKSRED VSNFDPDFIK EEPVLTPIDE 
GHLPMINQDE FRNFSYVSPE LQL

Genular Protein ID: 1143258017

Symbol: Q3UKY1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UKY1

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 683
Mass: 77889
Checksum: 11401B2FF099ED4D
Sequence:

MSSGTMKFNG YLRVRIGEAV GLQPTRWSLR HSLFKKGHQL LDPYLTVSVD QVRVGQTSTK 
QKTNKPTYNE EFCANVTDGG HLELAVFHET PLGYDHFVAN CTLQFQELLR TAGTSDTFEG 
WVDLEPEGKV FVVITLTGSF TEATLQRDRI FKHFTRKRQR AMRRRVHQVN GHKFMATYLR 
QPTYCSHCRE FIWGVFGKQG YQCQVCTCVV HKRCHHLIVT ACTCQNNINK VDAKIAEQRF 
GINIPHKFNV HNYKVPTFCD HCGSLLWGIM RQGLQCKICK MNVHIRCQAN VAPNCGVNAV 
ELAKTLAGMG LQPGNISPTS KLISRSTLRR QGKEGSKEGN GIGVNSSSRF GIDNFEFIRV 
LGKGSFGKVM LARIKETGEL YAVKVLKKDV ILQDDDVECT MAEKRILSLA RNHPFLTQLF 
CCFQTPDRLF FVMEFVNGGD LMFHIQKSRR FDEARARFYA AEIISALMFL HEKGIIYRDL 
KLDNVLLDHE GHCKLADFGM CKEGICNGVT TATFCGTPDY IAPEILQEML YGPAVDWWAM 
GVLLYEMLCG HAPFEAENED DLFEAILNDE VVYPTWLHED ATGILKSFMT KNPTMRLGSL 
TQGGEHEILR HPFFKEIDWA QLNHRQLEPP FRPRIKSRED VSNFDPDFIK EEPVLTPIDE 
GHLPMINQDE FRNFSYVSPE LQL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prkch

Associated with

Other Information

A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. PubMed ID: 2266135

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation. PubMed ID: 11106751

PKC eta directs induction of IRF-4 expression and Ig kappa gene rearrangement in pre-BCR signaling pathway. PubMed ID: 18780722

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Direct binding of RalA to PKC? and its crucial role in morphological change during keratinocyte differentiation. PubMed ID: 21346190

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073