Genular: Defining Cellular Identity and Function

Details for: Prkci

Gene ID: 18759

Symbol: Prkci

Ensembl ID: ENSMUSG00000037643

Description: protein kinase C, iota

Associated with

Cell-cell communication
(R-MMU-1500931)
Cell junction organization
(R-MMU-446728)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Death receptor signaling
(R-MMU-73887)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
P75ntr recruits signalling complexes
(R-MMU-209543)
P75ntr signals via nf-kb
(R-MMU-193639)
Pre-notch expression and processing
(R-MMU-1912422)
Pre-notch transcription and translation
(R-MMU-1912408)
Signaling by notch
(R-MMU-157118)
Signal transduction
(R-MMU-162582)
Tight junction interactions
(R-MMU-420029)
Actin filament organization
(GO:0007015)
Apical part of cell
(GO:0045177)
Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Bicellular tight junction
(GO:0005923)
Brush border
(GO:0005903)
Cell-cell junction organization
(GO:0045216)
Cell leading edge
(GO:0031252)
Cell migration
(GO:0016477)
Cellular response to insulin stimulus
(GO:0032869)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Diacylglycerol-dependent serine/threonine kinase activity
(GO:0004697)
Endosome
(GO:0005768)
Establishment of apical/basal cell polarity
(GO:0035089)
Establishment or maintenance of epithelial cell apical/basal polarity
(GO:0045197)
Eye photoreceptor cell development
(GO:0042462)
Glutamatergic synapse
(GO:0098978)
Golgi vesicle budding
(GO:0048194)
Intercellular bridge
(GO:0045171)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Microtubule cytoskeleton
(GO:0015630)
Multicellular organism development
(GO:0007275)
Negative regulation of glial cell apoptotic process
(GO:0034351)
Negative regulation of neuron apoptotic process
(GO:0043524)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Par polarity complex
(GO:0120157)
Peptidyl-serine phosphorylation
(GO:0018105)
Phospholipid binding
(GO:0005543)
Phosphorylation
(GO:0016310)
Positive regulation of endothelial cell apoptotic process
(GO:2000353)
Positive regulation of glial cell proliferation
(GO:0060252)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of postsynaptic membrane neurotransmitter receptor levels
(GO:0099072)
Response to interleukin-1
(GO:0070555)
Response to peptide hormone
(GO:0043434)
Schaffer collateral - ca1 synapse
(GO:0098685)
Schmidt-lanterman incisure
(GO:0043220)
Transferase activity
(GO:0016740)

Other Information

Proteins

Protein kinase C iota type
Q5DTK3_MOUSE

Genular Protein ID: 1045901671

Symbol: KPCI_MOUSE

Name: Protein kinase C iota type

UniProtKB Accession Codes:

Q62074

Database IDs:

Citations:

PubMed ID: 7513693

Title: A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.

PubMed ID: 7513693

DOI: 10.1016/s0021-9258(18)99929-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9971737

Title: Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton.

PubMed ID: 9971737

DOI: 10.1083/jcb.144.3.413

PubMed ID: 10934474

Title: The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.

PubMed ID: 10934474

DOI: 10.1038/35019573

PubMed ID: 12813044

Title: Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.

PubMed ID: 12813044

DOI: 10.1074/jbc.m303221200

PubMed ID: 12832475

Title: Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin.

PubMed ID: 12832475

DOI: 10.1128/mcb.23.14.4892-4900.2003

PubMed ID: 15322187

Title: Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms.

PubMed ID: 15322187

DOI: 10.4049/jimmunol.173.5.3250

PubMed ID: 14615604

Title: Protein kinase C-lambda knockout in embryonic stem cells and adipocytes impairs insulin-stimulated glucose transport.

PubMed ID: 14615604

DOI: 10.1210/me.2003-0087

PubMed ID: 16267237

Title: Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina.

PubMed ID: 16267237

DOI: 10.1523/jneurosci.3657-05.2005

PubMed ID: 16792529

Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.

PubMed ID: 16792529

DOI: 10.1042/bj20060511

PubMed ID: 17313651

Title: WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.

PubMed ID: 17313651

DOI: 10.1111/j.1742-4658.2007.05702.x

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20399730

Title: The apical complex couples cell fate and cell survival to cerebral cortical development.

PubMed ID: 20399730

DOI: 10.1016/j.neuron.2010.03.019

PubMed ID: 22579248

Title: Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKCiota in complex with a substrate peptide from Par-3.

PubMed ID: 22579248

DOI: 10.1016/j.str.2012.02.022

Sequence Information:

Length: 595
Mass: 68203
Checksum: 6AC612D1E9264825
Sequence:

MPTQRDSSTM SHTVACGGGG DHSHQVRVKA YYRGDIMITH FEPSISFEGL CSEVRDMCSF 
DNEQPFTMKW IDEEGDPCTV SSQLELEEAF RLYELNKDSE LLIHVFPCVP ERPGMPCPGE 
DKSIYRRGAR RWRKLYCANG HTFQAKRFNR RAHCAICTDR IWGLGRQGYK CINCKLLVHK 
KCHKLVTIEC GRHSLPPEPM MPMDQTMHPD HTQTVIPYNP SSHESLDQVG EEKEAMNTRE 
SGKASSSLGL QDFDLLRVIG RGSYAKVLLV RLKKTDRIYA MKVVKKELVN DDEDIDWVQT 
EKHVFEQASN HPFLVGLHSC FQTESRLFFV IEYVNGGDLM FHMQRQRKLP EEHARFYSAE 
ISLALNYLHE RGIIYRDLKL DNVLLDSEGH IKLTDYGMCK EGLRPGDTTS TFCGTPNYIA 
PEILRGEDYG FSVDWWALGV LMFEMMAGRS PFDIVGSSDN PDQNTEDYLF QVILEKQIRI 
PRSLSVKAAS VLKSFLNKDP KERLGCHPQT GFADIQGHPF FRNVDWDMME QKQVVPPFKP 
NISGEFGLDN FDSQFTNEPV QLTPDDDDIV RKIDQSEFEG FEYINPLLMS AEECV

Genular Protein ID: 1826033167

Symbol: Q5DTK3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q5DTK3

Database IDs:

Sequence Information:

Length: 674
Mass: 77222
Checksum: 324727A7727BC6E9
Sequence:

AWWEEPRREA CCAGRREERW GSGLAAKRPL ARSAPRARRV GRRGGRPRLP DRLGRPRPSR 
RPALPRPPRP PAARRGSEEM PTQRDSSTMS HTVACGGGGD HSHQVRVKAY YRGDIMITHF 
EPSISFEGLC SEVRDMCSFD NEQPFTMKWI DEEGDPCTVS SQLELEEAFR LYELNKDSEL 
LIHVFPCVPE RPGMPCPGED KSIYRRGARR WRKLYCANGH TFQAKRFNRR AHCAICTDRI 
WGLGRQGYKC INCKLLVHKK CHKLVTIECG RHSLPPEPMM PMDQTMHPDH TQTVIPYNPS 
SHESLDQVGE EKEAMNTRES GKASSSLGLQ DFDLLRVIGR GSYAKVLLVR LKKTDRIYAM 
KVVKKELVND DEDIDWVQTE KHVFEQASNH PFLVGLHSCF QTESRLFFVI EYVNGGDLMF 
HMQRQRKLPE EHARFYSAEI SLALNYLHER GIIYRDLKLD NVLLDSEGHI KLTDYGMCKE 
GLRPGDTTST FCGTPNYIAP EILRGEDYGF SVDWWALGVL MFEMMAGRSP FDIVGSSDNP 
DQNTEDYLFQ VILEKQIRIP RSLSVKAASV LKSFLNKDPK ERLGCHPQTG FADIQGHPFF 
RNVDWDMMEQ KQVVPPFKPN ISGEFGLDNF DSQFTNEPVQ LTPDDDDIVR KIDQSEFEGF 
EYINPLLMSA EECV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prkci

Associated with

Other Information

A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells. PubMed ID: 7513693

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton. PubMed ID: 9971737

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. PubMed ID: 10934474

Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. PubMed ID: 12813044

Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin. PubMed ID: 12832475

Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms. PubMed ID: 15322187

Protein kinase C-lambda knockout in embryonic stem cells and adipocytes impairs insulin-stimulated glucose transport. PubMed ID: 14615604

Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina. PubMed ID: 16267237

A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. PubMed ID: 16792529

WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. PubMed ID: 17313651

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The apical complex couples cell fate and cell survival to cerebral cortical development. PubMed ID: 20399730

Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKCiota in complex with a substrate peptide from Par-3. PubMed ID: 22579248