Details for: Prkd1

Gene ID: 18760

Symbol: Prkd1

Ensembl ID: ENSMUSG00000002688

Description: protein kinase D1

Associated with

  • Angiogenesis
    (GO:0001525)
  • Apoptotic process
    (GO:0006915)
  • Atp binding
    (GO:0005524)
  • Autophagosome membrane
    (GO:0000421)
  • Cell-cell junction
    (GO:0005911)
  • Cell cortex
    (GO:0005938)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to amino acid starvation
    (GO:0034198)
  • Cellular response to angiotensin
    (GO:1904385)
  • Cellular response to endothelin
    (GO:1990859)
  • Cellular response to hydroperoxide
    (GO:0071447)
  • Cellular response to norepinephrine stimulus
    (GO:0071874)
  • Cellular response to organic cyclic compound
    (GO:0071407)
  • Cellular response to oxidative stress
    (GO:0034599)
  • Cellular response to phorbol 13-acetate 12-myristate
    (GO:1904628)
  • Cellular response to vascular endothelial growth factor stimulus
    (GO:0035924)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Diacylglycerol-dependent serine/threonine kinase activity
    (GO:0004697)
  • Golgi apparatus
    (GO:0005794)
  • Golgi organization
    (GO:0007030)
  • Golgi vesicle transport
    (GO:0048193)
  • Heat shock protein binding
    (GO:0031072)
  • Identical protein binding
    (GO:0042802)
  • Immune system process
    (GO:0002376)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Intracellular signal transduction
    (GO:0035556)
  • Kinase activity
    (GO:0016301)
  • Membrane
    (GO:0016020)
  • Metal ion binding
    (GO:0046872)
  • Nervous system development
    (GO:0007399)
  • Nucleotide binding
    (GO:0000166)
  • Nucleus
    (GO:0005634)
  • Peptidyl-serine phosphorylation
    (GO:0018105)
  • Peptidyl-threonine phosphorylation
    (GO:0018107)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Phosphatidylinositol 3-kinase activator activity
    (GO:0141038)
  • Phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:0007200)
  • Phosphorylation
    (GO:0016310)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cell size
    (GO:0045793)
  • Positive regulation of endothelial cell chemotaxis
    (GO:2001028)
  • Positive regulation of endothelial cell chemotaxis by vegf-activated vascular endothelial growth factor receptor signaling pathway
    (GO:0038033)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of nlrp3 inflammasome complex assembly
    (GO:1900227)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of peptide hormone secretion
    (GO:0090277)
  • Positive regulation of peptidyl-serine phosphorylation
    (GO:0033138)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein export from nucleus
    (GO:0046827)
  • Positive regulation of protein import into nucleus
    (GO:0042307)
  • Positive regulation of sarcomere organization
    (GO:0060298)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein autophosphorylation
    (GO:0046777)
  • Protein binding
    (GO:0005515)
  • Protein kinase activity
    (GO:0004672)
  • Protein kinase c binding
    (GO:0005080)
  • Protein phosphorylation
    (GO:0006468)
  • Protein serine/threonine kinase activity
    (GO:0004674)
  • Protein serine kinase activity
    (GO:0106310)
  • Regulation of keratinocyte proliferation
    (GO:0010837)
  • Regulation of release of sequestered calcium ion into cytosol
    (GO:0051279)
  • Regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril
    (GO:0014723)
  • Response to norepinephrine
    (GO:0071873)
  • Trans-golgi network
    (GO:0005802)
  • Transferase activity
    (GO:0016740)
  • Vascular endothelial growth factor receptor signaling pathway
    (GO:0048010)
  • Z disc
    (GO:0030018)

Other Information

Genular Protein ID: 180347476

Symbol: KPCD1_MOUSE

Name: Serine/threonine-protein kinase D1

UniProtKB Accession Codes:

Q62101 E9QNA3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 4 CORUM 1 CTD 1 ChEBI 13 ChiTaRS 1 DNASU 1 EC 3 EMBL 5 Ensembl 1 GO 71 Gene3D 3 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 4 PaxDb 1 PeptideAtlas 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 7 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8078925

Title: Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain.

PubMed ID: 8078925

DOI: 10.1073/pnas.91.18.8572

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 10473617

Title: Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/protein kinase Cmu.

PubMed ID: 10473617

DOI: 10.1074/jbc.274.37.26543

PubMed ID: 11239398

Title: Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network.

PubMed ID: 11239398

DOI: 10.1016/s0092-8674(01)00228-8

PubMed ID: 11410586

Title: Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo.

PubMed ID: 11410586

DOI: 10.1074/jbc.m101648200

PubMed ID: 11784866

Title: The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.

PubMed ID: 11784866

DOI: 10.1128/mcb.22.3.916-926.2001

PubMed ID: 12407104

Title: Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain.

PubMed ID: 12407104

DOI: 10.1074/jbc.m208075200

PubMed ID: 15192707

Title: PKD1/PKCmu promotes alphavbeta3 integrin recycling and delivery to nascent focal adhesions.

PubMed ID: 15192707

DOI: 10.1038/sj.emboj.7600267

PubMed ID: 14963034

Title: Protein kinase D potentiates DNA synthesis induced by Gq-coupled receptors by increasing the duration of ERK signaling in swiss 3T3 cells.

PubMed ID: 14963034

DOI: 10.1074/jbc.m313225200

PubMed ID: 19029091

Title: Bone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2.

PubMed ID: 19029091

DOI: 10.1074/jbc.m800586200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20463010

Title: Protein kinase D is implicated in the reversible commitment to differentiation in primary cultures of mouse keratinocytes.

PubMed ID: 20463010

DOI: 10.1074/jbc.m110.105619

PubMed ID: 24161911

Title: The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.

PubMed ID: 24161911

DOI: 10.1016/j.yjmcc.2013.10.010

PubMed ID: 27184844

Title: An evolutionarily conserved PLC-PKD-TFEB pathway for host defense.

PubMed ID: 27184844

DOI: 10.1016/j.celrep.2016.04.052

PubMed ID: 28716882

Title: Protein kinase D at the Golgi controls NLRP3 inflammasome activation.

PubMed ID: 28716882

DOI: 10.1084/jem.20162040

Sequence Information:

  • Length: 918
  • Mass: 102037
  • Checksum: A59FEBAFCE0D0F13
  • Sequence:
    • MSVPPLLRPP SPLLPAAAAV AAAAAALVPG SGPAPFPAPG AAPAGGISFH LQIGLSREPV 
LLLQDSSGDY SLAHVREMAC SIVDQKFPEC GFYGLYDKIL LFRHDPASDN ILQLVKIASD 
IQEGDLIEVV LSASATFEDF QIRPHALFVH SYRAPAFCDH CGEMLWGLVR QGLKCEGCGL 
NYHKRCAFKI PNNCSGVRRR RLSNVSLTGL GTVRTASAEF STSVPDEPLL SPVSPGFEQK 
SPSESFIGRE KRSNSQSYIG RPIQLDKLLM SKVKVPHTFV IHSYTRPTVC QFCKKLLKGL 
FRQGLQCKDC RFNCHKRCAP KVPNNCLGEV TINGELLSPG AESDVVMEEG SDDNDSERNS 
GLMDDMDEAM VQDTEMALAE GQSGGAEMQD PDADQEDSNR TISPSTSNNI PLMRVVQSVK 
HTKRRSSTVM KEGWMVHYTS KDTLRKRHYW RLDSKCITLF QNDTGSRYYK EIPLSEILCL 
EPAKPSALTP VGATPHCFEI TTANVVYYVG ENVVNPSSSP PNNSVLPSGI GPDVARMWEV 
AIQHALMPVI PKGSSVGSGS NSHKDISVSI SVSNCQIQEN VDISTVYQIF PDEVLGSGQF 
GIVYGGKHRK TGRDVAIKII DKLRFPTKQE SQLRNEVAIL QNLHHPGVVN LECMFETPER 
VFVVMEKLHG DMLEMILSSE KGRLPEHITK FLITQILVAL RHLHFKNIVH CDLKPENVLL 
ASADPFPQVK LCDFGFARII GEKSFRRSVV GTPAYLAPEV LRNKGYNRSL DMWSVGVIIY 
VSLSGTFPFN EDEDIHDQIQ NAAFMYPPNP WKEISHEAID LINNLLQVKM RKRYSVDKTL 
SHPWLQDYQT WLDLRELECR IGERYITHES DDSRWEQYAG EQGLQYPAHL ISLSASHSDS 
PEAEEREMKA LSERVSIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.