Genular: Defining Cellular Identity and Function

Details for: Prkcq

Gene ID: 18761

Symbol: Prkcq

Ensembl ID: ENSMUSG00000026778

Description: protein kinase C, theta

Associated with

Adaptive immune system
(R-MMU-1280218)
Apoptosis
(R-MMU-109581)
Apoptotic cleavage of cellular proteins
(R-MMU-111465)
Apoptotic execution phase
(R-MMU-75153)
Axon guidance
(R-MMU-422475)
Developmental biology
(R-MMU-1266738)
Downstream tcr signaling
(R-MMU-202424)
Effects of pip2 hydrolysis
(R-MMU-114508)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Nervous system development
(R-MMU-9675108)
Netrin-1 signaling
(R-MMU-373752)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Programmed cell death
(R-MMU-5357801)
Raf/map kinase cascade
(R-MMU-5673001)
Ras processing
(R-MMU-9648002)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Tcr signaling
(R-MMU-202403)
Aggresome
(GO:0016235)
Atp binding
(GO:0005524)
Cd4-positive, alpha-beta t cell proliferation
(GO:0035739)
Cell chemotaxis
(GO:0060326)
Centriolar satellite
(GO:0034451)
Cytoplasm
(GO:0005737)
Diacylglycerol-dependent serine/threonine kinase activity
(GO:0004697)
Immune system process
(GO:0002376)
Immunological synapse
(GO:0001772)
Inflammatory response
(GO:0006954)
Interleukin-2 production
(GO:0032623)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Membrane
(GO:0016020)
Membrane protein ectodomain proteolysis
(GO:0006509)
Metal ion binding
(GO:0046872)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of t cell apoptotic process
(GO:0070233)
Neuromuscular junction
(GO:0031594)
Nucleotide binding
(GO:0000166)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of cd4-positive, alpha-beta t cell proliferation
(GO:2000563)
Positive regulation of filopodium assembly
(GO:0051491)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of protein secretion
(GO:0050714)
Positive regulation of stress fiber assembly
(GO:0051496)
Positive regulation of t-helper 2 cell activation
(GO:2000570)
Positive regulation of t-helper 17 type immune response
(GO:2000318)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of telomerase activity
(GO:0051973)
Positive regulation of telomere capping
(GO:1904355)
Positive regulation of telomere maintenance via telomerase
(GO:0032212)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of g2/m transition of mitotic cell cycle
(GO:0010389)
Regulation of platelet aggregation
(GO:0090330)
Sarcolemma
(GO:0042383)
T cell activation
(GO:0042110)
Transferase activity
(GO:0016740)

Other Information

Proteins

Protein kinase C theta type

Genular Protein ID: 2534721848

Symbol: KPCT_MOUSE

Name: Protein kinase C theta type

UniProtKB Accession Codes:

Q02111

Database IDs:

Citations:

PubMed ID: 1508194

Title: A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.

PubMed ID: 1508194

DOI: 10.1128/mcb.12.9.3930-3938.1992

PubMed ID: 10746729

Title: PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes.

PubMed ID: 10746729

DOI: 10.1038/35006090

PubMed ID: 12782715

Title: Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells.

PubMed ID: 12782715

DOI: 10.1084/jem.20020234

PubMed ID: 15263025

Title: Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses.

PubMed ID: 15263025

DOI: 10.1084/jem.20032229

PubMed ID: 16493044

Title: Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice.

PubMed ID: 16493044

DOI: 10.4049/jimmunol.176.5.2872

PubMed ID: 19047061

Title: Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance.

PubMed ID: 19047061

DOI: 10.1074/jbc.m806336200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 707
Mass: 81573
Checksum: 7A16492116CD2880
Sequence:

MSPFLRIGLS NFDCGTCQAC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP TMYPPWDSTF 
DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN GRTEIWLELK PQGRMLMNAR 
YFLEMSDTKD MSEFENEGFF ALHQRRGAIK QAKVHHVKCH EFTATFFPQP TFCSVCHEFV 
WGLNKQGYQC RQCNAAIHKK CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK 
SPTFCEHCGT LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ 
ARSLRDSEHI FREGPVEIGL PCSTKNETRP PCVPTPGKRE PQGISWDSPL DGSNKSAGPP 
EPEVSMRRTS LQLKLKIDDF ILHKMLGKGS FGKVFLAEFK RTNQFFAIKA LKKDVVLMDD 
DVECTMVEKR VLSLAWEHPF LTHMFCTFQT KENLFFVMEY LNGGDLMYHI QSCHKFDLSR 
ATFYAAEVIL GLQFLHSKGI VYRDLKLDNI LLDRDGHIKI ADFGMCKENM LGDAKTNTFC 
GTPDYIAPEI LLGQKYNHSV DWWSFGVLVY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR 
WLEREAKDLL VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP FRPKVKSPYD 
CSNFDKEFLS EKPRLSFADR ALINSMDQNM FSNFSFINPG METLICS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prkcq

Associated with

Other Information

A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. PubMed ID: 1508194

PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. PubMed ID: 10746729

Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells. PubMed ID: 12782715

Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses. PubMed ID: 15263025

Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice. PubMed ID: 16493044

Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance. PubMed ID: 19047061

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079