Genular: Defining Cellular Identity and Function

Details for: Prkcz

Gene ID: 18762

Symbol: Prkcz

Ensembl ID: ENSMUSG00000029053

Description: protein kinase C, zeta

Associated with

Esr-mediated signaling
(R-MMU-8939211)
Estrogen-stimulated signaling through prkcz
(R-MMU-9634635)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate nadph oxidases
(R-MMU-5668599)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Tgf-beta receptor signaling in emt (epithelial to mesenchymal transition)
(R-MMU-2173791)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegfr2 mediated cell proliferation
(R-MMU-5218921)
14-3-3 protein binding
(GO:0071889)
Anchoring junction
(GO:0070161)
Apical cortex
(GO:0045179)
Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Axon hillock
(GO:0043203)
Bicellular tight junction
(GO:0005923)
Cell-cell junction
(GO:0005911)
Cell cortex
(GO:0005938)
Cell leading edge
(GO:0031252)
Cell migration
(GO:0016477)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to insulin stimulus
(GO:0032869)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Diacylglycerol-dependent serine/threonine kinase activity
(GO:0004697)
Endosome
(GO:0005768)
Establishment of cell polarity
(GO:0030010)
Glutamatergic synapse
(GO:0098978)
Inflammatory response
(GO:0006954)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Long-term memory
(GO:0007616)
Long-term synaptic potentiation
(GO:0060291)
Membrane
(GO:0016020)
Membrane depolarization
(GO:0051899)
Membrane hyperpolarization
(GO:0060081)
Metal ion binding
(GO:0046872)
Microtubule cytoskeleton organization
(GO:0000226)
Microtubule organizing center
(GO:0005815)
Myelin sheath abaxonal region
(GO:0035748)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of peptidyl-tyrosine phosphorylation
(GO:0050732)
Negative regulation of protein-containing complex assembly
(GO:0031333)
Neuron projection extension
(GO:1990138)
Nuclear envelope
(GO:0005635)
Nuclear matrix
(GO:0016363)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Perinuclear region of cytoplasm
(GO:0048471)
Phospholipase binding
(GO:0043274)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of insulin receptor signaling pathway
(GO:0046628)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of interleukin-5 production
(GO:0032754)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-13 production
(GO:0032736)
Positive regulation of protein transport
(GO:0051222)
Positive regulation of synaptic transmission
(GO:0050806)
Positive regulation of t-helper 2 cell cytokine production
(GO:2000553)
Positive regulation of t-helper 2 cell differentiation
(GO:0045630)
Postsynaptic density
(GO:0014069)
Potassium channel regulator activity
(GO:0015459)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein kinase c signaling
(GO:0070528)
Protein localization to plasma membrane
(GO:0072659)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
(GO:0098696)
Schaffer collateral - ca1 synapse
(GO:0098685)
Stress fiber
(GO:0001725)
Transferase activity
(GO:0016740)
Vesicle
(GO:0031982)
Vesicle transport along microtubule
(GO:0047496)

Other Information

Proteins

Protein kinase C zeta type
Q3V341_MOUSE

Genular Protein ID: 3969888094

Symbol: KPCZ_MOUSE

Name: Protein kinase C zeta type

UniProtKB Accession Codes:

Q02956 A2AD76 Q3UHM5 Q7TST7

Database IDs:

Citations:

PubMed ID: 1487145

Title: The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta.

PubMed ID: 1487145

DOI: 10.1016/0378-1119(92)90219-f

PubMed ID: 12932816

Title: PKC zeta II, a small molecule of protein kinase C zeta, specifically expressed in the mouse brain.

PubMed ID: 12932816

DOI: 10.1016/s0304-3940(03)00780-8

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 10934474

Title: The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.

PubMed ID: 10934474

DOI: 10.1038/35019573

PubMed ID: 15987782

Title: Control of T helper 2 cell function and allergic airway inflammation by PKCzeta.

PubMed ID: 15987782

DOI: 10.1073/pnas.0501202102

PubMed ID: 16792529

Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.

PubMed ID: 16792529

DOI: 10.1042/bj20060511

PubMed ID: 17313651

Title: WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.

PubMed ID: 17313651

DOI: 10.1111/j.1742-4658.2007.05702.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21131967

Title: Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling.

PubMed ID: 21131967

DOI: 10.1038/ni.1968

PubMed ID: 23283171

Title: Prkcz null mice show normal learning and memory.

PubMed ID: 23283171

DOI: 10.1038/nature11803

PubMed ID: 27187150

Title: Compensation for PKMzeta in long-term potentiation and spatial long-term memory in mutant mice.

PubMed ID: 27187150

DOI: 10.7554/elife.14846

Sequence Information:

Length: 592
Mass: 67682
Checksum: 690AD891C25BC311
Sequence:

MPSRTDPKMD RSGGRVRLKA HYGGDILITS VDAMTTFKDL CEEVRDMCGL HQQHPLTLKW 
VDSEGDPCTV SSQMELEEAF RLVCQGRDEV LIIHVFPSIP EQPGMPCPGE DKSIYRRGAR 
RWRKLYRANG HLFQAKRFNR GAYCGQCSER IWGLSRQGYR CINCKLLVHK RCHVLVPLTC 
RRHMDSVMPS QEPPVDDKND GVDLPSEETD GIAYISSSRK HDNIKDDSED LKPVIDGVDG 
IKISQGLGLQ DFDLIRVIGR GSYAKVLLVR LKKNDQIYAM KVVKKELVHD DEDIDWVQTE 
KHVFEQASSN PFLVGLHSCF QTTSRLFLVI EYVNGGDLMF HMQRQRKLPE EHARFYAAEI 
CIALNFLHER GIIYRDLKLD NVLLDADGHI KLTDYGMCKE GLGPGDTTST FCGTPNYIAP 
EILRGEEYGF SVDWWALGVL MFEMMAGRSP FDIITDNPDM NTEDYLFQVI LEKPIRIPRF 
LSVKASHVLK GFLNKDPKER LGCRPQTGFS DIKSHAFFRS IDWDLLEKKQ TLPPFQPQIT 
DDYGLDNFDT QFTSEPVQLT PDDEDVIKRI DQSEFEGFEY INPLLLSAEE SV

Genular Protein ID: 2775130736

Symbol: Q3V341_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3V341

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 409
Mass: 46601
Checksum: F233CE0BBD7D324E
Sequence:

MDSVMPSQEP PVDDKNDGVD LPSEETDGIA YISSSRKHDN IKDDSEDLKP VIDGVDGIKI 
SQGLGLQDFD LIRVIGRGSY AKVLLVRLKK NDQIYAMKVV KKELVHDDED IDWVQTEKHV 
FEQASSNPFL VGLHSCFQTT SRLFLVIEYV NGGDLMFHMQ RQRKLPEEHA RFYAAEICIA 
LNFLHERGII YRDLKLDNVL LDADGHIKLT DYGMCKEGLG PGDTTSTFCG TPNYIAPEIL 
RGEEYGFSVD WWALGVLMFE MMAGRSPFDI ITDNPDMNTE DYLFQVILEK PIRIPRFLSV 
KASHVLKGFL NKDPKERLGC RPQTGFSDIK SHAFFRSIDW DLLEKKQTLP PFQPQITDDY 
GLDNFDTQFT SEPVQLTPDD EDVIKRIDQS EFEGFEYINP LLLSAEESV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prkcz

Associated with

Other Information

The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta. PubMed ID: 1487145

PKC zeta II, a small molecule of protein kinase C zeta, specifically expressed in the mouse brain. PubMed ID: 12932816

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. PubMed ID: 10934474

Control of T helper 2 cell function and allergic airway inflammation by PKCzeta. PubMed ID: 15987782

A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. PubMed ID: 16792529

WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. PubMed ID: 17313651

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling. PubMed ID: 21131967

Prkcz null mice show normal learning and memory. PubMed ID: 23283171

Compensation for PKMzeta in long-term potentiation and spatial long-term memory in mutant mice. PubMed ID: 27187150

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 1487145

PubMed ID: 12932816

PubMed ID: 16141072

PubMed ID: 19468303

PubMed ID: 10934474

PubMed ID: 15987782

PubMed ID: 16792529

PubMed ID: 17313651

PubMed ID: 21183079

PubMed ID: 21131967

PubMed ID: 23283171

PubMed ID: 27187150

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 21183079