Details for: Pkd2
Associated with
Other Information
Genular Protein ID: 2207110068
Symbol: PKD2_MOUSE
Name: Polycystin-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9339380
Title: Molecular cloning, cDNA sequence analysis, and chromosomal localization of mouse Pkd2.
PubMed ID: 9339380
PubMed ID: 9716661
Title: Characterization of the murine polycystic kidney disease (Pkd2) gene.
PubMed ID: 9716661
PubMed ID: 16192288
Title: A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1.
PubMed ID: 16192288
DOI: 10.1093/hmg/ddi356
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 10873385
Title: Cloning and characterization of the murine pkd2 promoter.
PubMed ID: 10873385
PubMed ID: 9568711
Title: Somatic inactivation of Pkd2 results in polycystic kidney disease.
PubMed ID: 9568711
PubMed ID: 10770959
Title: Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene.
PubMed ID: 10770959
DOI: 10.1681/asn.v115814
PubMed ID: 10913159
Title: In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2.
PubMed ID: 10913159
PubMed ID: 10615132
Title: Cardiac defects and renal failure in mice with targeted mutations in Pkd2.
PubMed ID: 10615132
DOI: 10.1038/71724
PubMed ID: 10760273
Title: The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton.
PubMed ID: 10760273
PubMed ID: 12062060
Title: The ion channel polycystin-2 is required for left-right axis determination in mice.
PubMed ID: 12062060
PubMed ID: 11854751
Title: Polycystin-2 is an intracellular calcium release channel.
PubMed ID: 11854751
DOI: 10.1038/ncb754
PubMed ID: 12514735
Title: Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells.
PubMed ID: 12514735
DOI: 10.1038/ng1076
PubMed ID: 15692563
Title: Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.
PubMed ID: 15692563
PubMed ID: 16551655
Title: Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro.
PubMed ID: 16551655
DOI: 10.1093/hmg/ddl070
PubMed ID: 18235101
Title: Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.
PubMed ID: 18235101
PubMed ID: 18695040
Title: TRPP2 and TRPV4 form a polymodal sensory channel complex.
PubMed ID: 18695040
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20096584
Title: Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation.
PubMed ID: 20096584
PubMed ID: 21670265
Title: Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases.
PubMed ID: 21670265
PubMed ID: 21307093
Title: Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.
PubMed ID: 21307093
DOI: 10.1242/dev.058149
PubMed ID: 22983710
Title: Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2.
PubMed ID: 22983710
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25405894
Title: Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.
PubMed ID: 25405894
DOI: 10.1038/ncomms6482
PubMed ID: 27214281
Title: The polycystin complex mediates Wnt/Ca(2+) signalling.
PubMed ID: 27214281
DOI: 10.1038/ncb3363
PubMed ID: 27760766
Title: The native TRPP2-dependent channel of murine renal primary cilia.
PubMed ID: 27760766
PubMed ID: 31048699
Title: TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells.
PubMed ID: 31048699
Sequence Information:
- Length: 966
- Mass: 108982
- Checksum: 59B96AB3AE5226D3
- Sequence:
MVNSRRVQPQ PPGDAGRSPA PRASGPGRLV AGGAGLAVPG GLGEQRGLEI EMERIRQAAA RDPPAGASAS PSPPLSSCSR QAWSRDNPGF EAEEDDDDDE VEGEEGGMVV EMDVEWRPGS RRSASSSAVS SVGARGRGLG SYRGAAHLSG RRRRLEDQGA QCPSPAGGGD PLHRHLPLEG QPPRVAWAER LVRGLRGLWG TRLMEESNAN REKYLKSVLR ELVTYLFFLV VLCILTYGMM SSNVYYYTRT LSQLFIDTPV SKTEKTNFKT LSSMEDFWKF TEGSFLDGLY WKAQTSNHTQ ADNRSFIFYE NLLLGVPRLR QLRVRNGSCS IPQDLRDEIK ECYDVYSVSS EDRAPFGPRN GTAWMYTSEK ELNGSSHWGI IASYSGAGYY LDLSRTREET AAQLAGLRRN FWLDRGTRAA FIDFSVYNAN INLFCVVRLL AEFPATGGVV PSWQFQPVKL IRYVTAFDFF LAACEIIFCF FIIYYVVEEI LEIRIHRLSY FRSFWNCLDV VIVVLSVVAM VINIYRMSNA EGLLQFLEDQ NSFPNFEHVA YWQIQFNNIS AVMVFLVWIK LFKFINFNRT MSQLSTTMSR CAKDLFGFTI MFSIIFLAYA QLAYLVFGTQ VDDFSTFQEC IFTQFRIILG DINFAEIEEA NRVLGPLYFT TFVFFMFFIL LNMFLAIIND SYSEVKSDLA QQKAEMELSD LIRKGCQKAL VKLKLKRNTV DAISESLRQG GGKLNFDELR QDLKGKGHTD AEIEAIFTKY DQDGDQELTE REHQQMRDDL EKEREDLDLE HSSLPRPMSS RSFPRSLDDS EEEDDEDSGH SSRRRGSISS GVSYEEFQVL VRRVDRMEHS IGSIVSKIDA VIVKLEIMER AKLKRREVLG RLLDGVAEDA RLGRDSEIHR EQMERLVREE LERWESDDAA SQTGHGVSTQ VGLGGQPHPR NPRPPSSQSA EGLEGGGGNG SANVHA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.