Genular: Defining Cellular Identity and Function

Details for: Pla2r1

Gene ID: 18779

Symbol: Pla2r1

Ensembl ID: ENSMUSG00000054580

Description: phospholipase A2 receptor 1

Associated with

Acyl chain remodelling of pc
(R-MMU-1482788)
Acyl chain remodelling of pe
(R-MMU-1482839)
Acyl chain remodelling of pg
(R-MMU-1482925)
Acyl chain remodelling of pi
(R-MMU-1482922)
Acyl chain remodelling of ps
(R-MMU-1482801)
Glycerophospholipid biosynthesis
(R-MMU-1483206)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Phospholipid metabolism
(R-MMU-1483257)
Synthesis of pa
(R-MMU-1483166)
Carbohydrate binding
(GO:0030246)
Cell surface
(GO:0009986)
Endocytosis
(GO:0006897)
Extracellular region
(GO:0005576)
Membrane
(GO:0016020)
Negative regulation of arachidonic acid secretion
(GO:1900139)
Negative regulation of phospholipase a2 activity
(GO:1900138)
Oxidative stress-induced premature senescence
(GO:0090403)
Phospholipase binding
(GO:0043274)
Plasma membrane
(GO:0005886)
Positive regulation of arachidonic acid secretion
(GO:0090238)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of dna damage response, signal transduction by p53 class mediator
(GO:0043517)
Positive regulation of podocyte apoptotic process
(GO:1904635)
Reactive oxygen species metabolic process
(GO:0072593)
Receptor-mediated endocytosis
(GO:0006898)
Receptor complex
(GO:0043235)
Replicative senescence
(GO:0090399)
Signaling receptor activity
(GO:0038023)

Other Information

Proteins

Secretory phospholipase A2 receptor
Q8CB47_MOUSE

Genular Protein ID: 2654222702

Symbol: PLA2R_MOUSE

Name: Secretory phospholipase A2 receptor

UniProtKB Accession Codes:

Q62028 A2AS64 B9EJ68 Q80ZL5

Database IDs:

Citations:

PubMed ID: 7925459

Title: Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals.

PubMed ID: 7925459

DOI: 10.1111/j.1432-1033.1994.00375.x

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9407054

Title: Resistance to endotoxic shock in phospholipase A2 receptor-deficient mice.

PubMed ID: 9407054

DOI: 10.1074/jbc.272.52.32792

PubMed ID: 10066760

Title: Both group IB and group IIA secreted phospholipases A2 are natural ligands of the mouse 180-kDa M-type receptor.

PubMed ID: 10066760

DOI: 10.1074/jbc.274.11.7043

PubMed ID: 10864436

Title: Enhanced tissue expression and elevated circulating level of phospholipase A(2) receptor during murine endotoxic shock.

PubMed ID: 10864436

DOI: 10.1006/abbi.2000.1849

PubMed ID: 11019817

Title: Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor.

PubMed ID: 11019817

DOI: 10.1006/abbi.2000.1977

PubMed ID: 10922494

Title: Identification of group X secretory phospholipase A(2) as a natural ligand for mouse phospholipase A(2) receptor.

PubMed ID: 10922494

DOI: 10.1016/s0014-5793(00)01848-2

PubMed ID: 10946309

Title: Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells.

PubMed ID: 10946309

DOI: 10.4049/jimmunol.165.5.2773

PubMed ID: 11481246

Title: Pancreatic phospholipase A2 via its receptor regulates expression of key enzymes of phospholipid and sphingolipid metabolism.

PubMed ID: 11481246

DOI: 10.1096/fj.00-0831fje

PubMed ID: 11741598

Title: Clearance of group X secretory phospholipase A(2) via mouse phospholipase A(2) receptor.

PubMed ID: 11741598

DOI: 10.1016/s0014-5793(01)03173-8

PubMed ID: 12225974

Title: Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion.

PubMed ID: 12225974

DOI: 10.1152/ajpcell.00608.2001

PubMed ID: 11830583

Title: Identification of a soluble form phospholipase A2 receptor as a circulating endogenous inhibitor for secretory phospholipase A2.

PubMed ID: 11830583

DOI: 10.1074/jbc.m108752200

PubMed ID: 16815622

Title: Binding to the high-affinity M-type receptor for secreted phospholipases A(2) is not obligatory for the presynaptic neurotoxicity of ammodytoxin A.

PubMed ID: 16815622

DOI: 10.1016/j.biochi.2006.06.008

PubMed ID: 17279628

Title: Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor.

PubMed ID: 17279628

DOI: 10.1021/bi062119b

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1487
Mass: 170512
Checksum: AD8D905859B0EDE8
Sequence:

MVQWLAMLQL LWLQQLLLLG IHQGIAQDLT HIQEPSLEWR DKGIFIIQSE SLKTCIQAGK 
SVLTLENCKQ PNEHMLWKWV SDDHLFNVGG SGCLGLNISA LEQPLKLYEC DSTLISLRWH 
CDRKMIEGPL QYKVQVKSDN TVVARKQIHR WIAYTSSGGD ICEHPSRDLY TLKGNAHGMP 
CVFPFQFKGH WHHDCIREGQ KEHLLWCATT SRYEEDEKWG FCPDPTSMKV FCDATWQRNG 
SSRICYQFNL LSSLSWNQAH SSCLMQGGAL LSIADEDEED FIRKHLSKVV KEVWIGLNQL 
DEKAGWQWSD GTPLSYLNWS QEITPGPFVE HHCGTLEVVS AAWRSRDCES TLPYICKRDL 
NHTAQGILEK DSWKYHATHC DPDWTPFNRK CYKLKKDRKS WLGALHSCQS NDSVLMDVAS 
LAEVEFLVSL LRDENASETW IGLSSNKIPV SFEWSSGSSV IFTNWYPLEP RILPNRRQLC 
VSAEESDGRW KVKDCKERLF YICKKAGQVP ADEQSGCPAG WERHGRFCYK IDTVLRSFEE 
ASSGYYCSPA LLTITSRFEQ AFITSLISSV AEKDSYFWIA LQDQNNTGEY TWKTVGQREP 
VQYTYWNTRQ PSNRGGCVVV RGGSSLGRWE VKDCSDFKAM SLCKTPVKIW EKTELEERWP 
FHPCYMDWES ATGLASCFKV FHSEKVLMKR SWREAEAFCE EFGAHLASFA HIEEENFVNE 
LLHSKFNWTQ ERQFWIGFNR RNPLNAGSWA WSDGSPVVSS FLDNAYFEED AKNCAVYKAN 
KTLLPSNCAS KHEWICRIPR DVRPKFPDWY QYDAPWLFYQ NAEYLFHTHP AEWATFEFVC 
GWLRSDFLTI YSAQEQEFIH SKIKGLTKYG VKWWIGLEEG GARDQIQWSN GSPVIFQNWD 
KGREERVDSQ RKRCVFISSI TGLWGTENCS VPLPSICKRV KIWVIEKEKP PTQPGTCPKG 
WLYFNYKCFL VTIPKDPREL KTWTGAQEFC VAKGGTLVSI KSELEQAFIT MNLFGQTTNV 
WIGLQSTNHE KWVNGKPLVY SNWSPSDIIN IPSYNTTEFQ KHIPLCALMS SNPNFHFTGK 
WYFDDCGKEG YGFVCEKMQD TLEHHVNVSD TSAIPSTLEY GNRTYKIIRG NMTWYAAGKS 
CRMHRAELAS IPDAFHQAFL TVLLSRLGHT HWIGLSTTDN GQTFDWSDGT KSPFTYWKDE 
ESAFLGDCAF ADTNGRWHST ACESFLQGAI CHVVTETKAF EHPGLCSETS VPWIKFKGNC 
YSFSTVLDSR SFEDAHEFCK SEGSNLLAIR DAAENSFLLE ELLAFGSSVQ MVWLNAQFDN 
NNKTLRWFDG TPTEQSNWGL RKPDMDHLKP HPCVVLRIPE GIWHFTPCED KKGFICKMEA 
GIPAVTAQPE KGLSHSIVPV TVTLTLIIAL GIFMLCFWIY KQKSDIFQRL TGSRGSYYPT 
LNFSTAHLEE NILISDLEKN TNDEEVRDAP ATESKRGHKG RPICISP

Genular Protein ID: 1785857587

Symbol: Q8CB47_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CB47

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 537
Mass: 60555
Checksum: 94B00035C3115B37
Sequence:

PTQPGTCPKG WLYFNYKCFL VTIPKDPREL KTWTGAQEFC VAKGGTLVSI KSELEQAFIT 
MNLFGQTTNV WIGLQSTNHE KWVNGKPLVY SNWSPSDIIN IPSYNTTEFQ KHIPLCALMS 
SNPNFHFTGK WYFDDCGKEG YGFVCEKMQD TLEHHVNVSD TSAIPSTLEY GNRTYKIIRG 
NMTWYAAGKS CRMHRAELAS IPDAFHQAFL TVLLSRLGHT HWIGLSTTDN GQTFDWSDGT 
KSPFTYWKDE ESAFLGDCAF ADTNGRWHST ACESFLQGAI CHVVTETKAF EHPGLCSETS 
VPWIKFKGNC YSFSTVLDGR SFEDAHEFCK SEGSNLLAIR DAAENSFLLE ELLAFGSSVQ 
MVWLNAQFDN NNKTLRWFDG TPTEQSNWGL RKPDMDHLKP HPCVVLRIPE GIWHFTPCED 
KKGFICKMEA GIPAVTAQPE KGLSHSIVPV TVTLTLIIAL GIFMLCFWIY KQKSDIFQRL 
TGSRGSYYPT LNFSTAHLEE NILISDLEKN TNDEEVRDAP ATESKRGHKG RPICISP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pla2r1

Associated with

Other Information

Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals. PubMed ID: 7925459

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Resistance to endotoxic shock in phospholipase A2 receptor-deficient mice. PubMed ID: 9407054

Both group IB and group IIA secreted phospholipases A2 are natural ligands of the mouse 180-kDa M-type receptor. PubMed ID: 10066760

Enhanced tissue expression and elevated circulating level of phospholipase A(2) receptor during murine endotoxic shock. PubMed ID: 10864436

Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor. PubMed ID: 11019817

Identification of group X secretory phospholipase A(2) as a natural ligand for mouse phospholipase A(2) receptor. PubMed ID: 10922494

Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells. PubMed ID: 10946309

Pancreatic phospholipase A2 via its receptor regulates expression of key enzymes of phospholipid and sphingolipid metabolism. PubMed ID: 11481246

Clearance of group X secretory phospholipase A(2) via mouse phospholipase A(2) receptor. PubMed ID: 11741598

Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion. PubMed ID: 12225974

Identification of a soluble form phospholipase A2 receptor as a circulating endogenous inhibitor for secretory phospholipase A2. PubMed ID: 11830583

Binding to the high-affinity M-type receptor for secreted phospholipases A(2) is not obligatory for the presynaptic neurotoxicity of ammodytoxin A. PubMed ID: 16815622

Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor. PubMed ID: 17279628

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073