Genular: Defining Cellular Identity and Function

Details for: Pla2g2a

Gene ID: 18780

Symbol: Pla2g2a

Ensembl ID: ENSMUSG00000058908

Description: phospholipase A2, group IIA (platelets, synovial fluid)

Associated with

Acyl chain remodelling of pc
(R-MMU-1482788)
Acyl chain remodelling of pe
(R-MMU-1482839)
Acyl chain remodelling of pg
(R-MMU-1482925)
Acyl chain remodelling of pi
(R-MMU-1482922)
Acyl chain remodelling of ps
(R-MMU-1482801)
Antimicrobial peptides
(R-MMU-6803157)
Glycerophospholipid biosynthesis
(R-MMU-1483206)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Phospholipid metabolism
(R-MMU-1483257)
Synthesis of pa
(R-MMU-1483166)
Calcium-dependent phospholipase a2 activity
(GO:0047498)
Calcium ion binding
(GO:0005509)
Cell population proliferation
(GO:0008283)
Defense response to gram-positive bacterium
(GO:0050830)
Endoplasmic reticulum
(GO:0005783)
Extracellular space
(GO:0005615)
Intestinal stem cell homeostasis
(GO:0036335)
Mitochondrion
(GO:0005739)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of t cell proliferation
(GO:0042130)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatidic acid metabolic process
(GO:0046473)
Phosphatidylcholine metabolic process
(GO:0046470)
Phosphatidylethanolamine metabolic process
(GO:0046337)
Phospholipase a2 activity
(GO:0004623)
Phospholipid binding
(GO:0005543)
Phospholipid metabolic process
(GO:0006644)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Prostaglandin biosynthetic process
(GO:0001516)
Regulation of cell population proliferation
(GO:0042127)
Regulation of endothelial cell proliferation
(GO:0001936)
Regulation of epithelial cell proliferation
(GO:0050678)
Regulation of neutrophil activation
(GO:1902563)
Secretory granule
(GO:0030141)
Somatic stem cell population maintenance
(GO:0035019)

Other Information

Proteins

Phospholipase A2, membrane associated

Genular Protein ID: 2971988016

Symbol: PA2GA_MOUSE

Name: Phospholipase A2, membrane associated

UniProtKB Accession Codes:

P31482 Q60871

Database IDs:

Citations:

PubMed ID: 7673223

Title: A natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains.

PubMed ID: 7673223

DOI: 10.1074/jbc.270.38.22378

PubMed ID: 7781071

Title: The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.

PubMed ID: 7781071

DOI: 10.1016/0092-8674(95)90015-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8267767

Title: Enhancing factor, a Paneth cell specific protein from mouse small intestines: predicted amino acid sequence from RT-PCR amplified cDNA and its expression.

PubMed ID: 8267767

DOI: 10.1006/bbrc.1993.2179

PubMed ID: 8250944

Title:

PubMed ID: 8250944

DOI: 10.1006/bbrc.1993.2485

PubMed ID: 8425615

Title: Enhancing factor protein from mouse small intestines belongs to the phospholipase A2 family.

PubMed ID: 8425615

DOI: 10.1016/0014-5793(93)81289-c

PubMed ID: 10358193

Title: Protection by group II phospholipase A2 against Staphylococcus aureus.

PubMed ID: 10358193

PubMed ID: 11694541

Title: Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2).

PubMed ID: 11694541

DOI: 10.1074/jbc.m109699200

PubMed ID: 27292189

Title: Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.

PubMed ID: 27292189

DOI: 10.1016/j.stem.2016.05.023

Sequence Information:

Length: 146
Mass: 16145
Checksum: AB904F6B3B1BA5C7
Sequence:

MKVLLLLAAS IMAFGSIQVQ GNIAQFGEMI RLKTGKRAEL SYAFYGCHCG LGGKGSPKDA 
TDRCCVTHDC CYKSLEKSGC GTKLLKYKYS HQGGQITCSA NQNSCQKRLC QCDKAAAECF 
ARNKKTYSLK YQFYPNMFCK GKKPKC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pla2g2a

Associated with

Other Information

A natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains. PubMed ID: 7673223

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia. PubMed ID: 7781071

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Enhancing factor, a Paneth cell specific protein from mouse small intestines: predicted amino acid sequence from RT-PCR amplified cDNA and its expression. PubMed ID: 8267767