Genular: Defining Cellular Identity and Function

Details for: Pla2g2d

Gene ID: 18782

Symbol: Pla2g2d

Ensembl ID: ENSMUSG00000041202

Description: phospholipase A2, group IID

Associated with

Acyl chain remodelling of pc
(R-MMU-1482788)
Acyl chain remodelling of pe
(R-MMU-1482839)
Acyl chain remodelling of pg
(R-MMU-1482925)
Acyl chain remodelling of pi
(R-MMU-1482922)
Acyl chain remodelling of ps
(R-MMU-1482801)
Glycerophospholipid biosynthesis
(R-MMU-1483206)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Phospholipid metabolism
(R-MMU-1483257)
Synthesis of pa
(R-MMU-1483166)
Arachidonic acid secretion
(GO:0050482)
Calcium-dependent phospholipase a2 activity
(GO:0047498)
Calcium ion binding
(GO:0005509)
Cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation
(GO:0002361)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Heparan sulfate proteoglycan binding
(GO:0043395)
Heparin binding
(GO:0008201)
Hydrolase activity
(GO:0016787)
Inflammatory response
(GO:0006954)
Lipid catabolic process
(GO:0016042)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of t cell activation
(GO:0050868)
Negative regulation of t cell proliferation
(GO:0042130)
Phosphatidylcholine metabolic process
(GO:0046470)
Phosphatidylethanolamine metabolic process
(GO:0046337)
Phosphatidylglycerol metabolic process
(GO:0046471)
Phospholipase a2 activity
(GO:0004623)
Phospholipid binding
(GO:0005543)
Phospholipid metabolic process
(GO:0006644)
Plasma membrane
(GO:0005886)
Regulation of acute inflammatory response to antigenic stimulus
(GO:0002864)

Other Information

Proteins

Group IID secretory phospholipase A2

Genular Protein ID: 1773692918

Symbol: PA2GD_MOUSE

Name: Group IID secretory phospholipase A2

UniProtKB Accession Codes:

Q9WVF6 Q3V4B8 Q9JLK0

Database IDs:

Citations:

PubMed ID: 10455175

Title: Cloning and characterization of novel mouse and human secretory phospholipase A2s.

PubMed ID: 10455175

DOI: 10.1074/jbc.274.35.24973

PubMed ID: 10383420

Title: Cloning and recombinant expression of a novel mouse-secreted phospholipase A2.

PubMed ID: 10383420

DOI: 10.1074/jbc.274.27.19152

PubMed ID: 11196711

Title: SPLASH (PLA(2)IID), a novel member of phospholipase A2 family, is associated with lymphotoxin-deficiency.

PubMed ID: 11196711

DOI: 10.1038/sj.gene.6363659

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10531313

Title: On the diversity of secreted phospholipases A2. Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes.

PubMed ID: 10531313

DOI: 10.1074/jbc.274.44.31195

PubMed ID: 11694541

Title: Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2).

PubMed ID: 11694541

DOI: 10.1074/jbc.m109699200

PubMed ID: 19564598

Title: Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells.

PubMed ID: 19564598

DOI: 10.1073/pnas.0812569106

PubMed ID: 23690440

Title: Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.

PubMed ID: 23690440

DOI: 10.1084/jem.20121887

PubMed ID: 26392224

Title: Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.

PubMed ID: 26392224

DOI: 10.1084/jem.20150632

PubMed ID: 27226632

Title: Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer.

PubMed ID: 27226632

DOI: 10.1074/jbc.m116.734624

Sequence Information:

Length: 144
Mass: 16164
Checksum: 7697ADA07F8D270A
Sequence:

MRLALLCGLL LAGITATQGG LLNLNKMVTH MTGKKAFFSY WPYGCHCGLG GKGQPKDATD 
WCCQKHDCCY AHLKIDGCKS LTDNYKYSIS QGTIQCSDNG SWCERQLCAC DKEVALCLKQ 
NLDSYNKRLR YYWRPRCKGK TPAC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pla2g2d

Associated with

Other Information

Cloning and characterization of novel mouse and human secretory phospholipase A2s. PubMed ID: 10455175

Cloning and recombinant expression of a novel mouse-secreted phospholipase A2. PubMed ID: 10383420

SPLASH (PLA(2)IID), a novel member of phospholipase A2 family, is associated with lymphotoxin-deficiency. PubMed ID: 11196711

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

On the diversity of secreted phospholipases A2. Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes. PubMed ID: 10531313

Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2). PubMed ID: 11694541

Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells. PubMed ID: 19564598

Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators. PubMed ID: 23690440

Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection. PubMed ID: 26392224

Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer. PubMed ID: 27226632