Genular: Defining Cellular Identity and Function

Details for: Pla2g5

Gene ID: 18784

Symbol: Pla2g5

Ensembl ID: ENSMUSG00000041193

Description: phospholipase A2, group V

Associated with

Acyl chain remodelling of pc
(R-MMU-1482788)
Acyl chain remodelling of pe
(R-MMU-1482839)
Acyl chain remodelling of pg
(R-MMU-1482925)
Acyl chain remodelling of pi
(R-MMU-1482922)
Acyl chain remodelling of ps
(R-MMU-1482801)
Glycerophospholipid biosynthesis
(R-MMU-1483206)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Phospholipid metabolism
(R-MMU-1483257)
Synthesis of pa
(R-MMU-1483166)
Arachidonic acid secretion
(GO:0050482)
Calcium-dependent phospholipase a2 activity
(GO:0047498)
Calcium-independent phospholipase a2 activity
(GO:0047499)
Calcium ion binding
(GO:0005509)
Cardiolipin acyl-chain remodeling
(GO:0035965)
Cell surface
(GO:0009986)
Cytoplasmic vesicle
(GO:0031410)
Early phagosome
(GO:0032009)
Endosome
(GO:0005768)
Extracellular region
(GO:0005576)
Fatty acid metabolic process
(GO:0006631)
Golgi apparatus
(GO:0005794)
Heparin binding
(GO:0008201)
Hydrolase activity
(GO:0016787)
Leukotriene biosynthetic process
(GO:0019370)
Lipid catabolic process
(GO:0016042)
Lipid metabolic process
(GO:0006629)
Low-density lipoprotein particle remodeling
(GO:0034374)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of t cell proliferation
(GO:0042130)
Perinuclear region of cytoplasm
(GO:0048471)
Phagocytosis
(GO:0006909)
Phagolysosome
(GO:0032010)
Phagosome-lysosome fusion
(GO:0090385)
Phosphatidylcholine catabolic process
(GO:0034638)
Phospholipase a2 activity
(GO:0004623)
Phospholipid binding
(GO:0005543)
Phospholipid catabolic process
(GO:0009395)
Phospholipid metabolic process
(GO:0006644)
Plasma membrane
(GO:0005886)
Platelet activating factor biosynthetic process
(GO:0006663)
Positive regulation of antifungal innate immune response
(GO:1905036)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of immune complex clearance by monocytes and macrophages
(GO:0090265)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of opsonization
(GO:1903028)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of phagosome maturation
(GO:1905164)
Positive regulation of phospholipase activity
(GO:0010518)
Regulation of macrophage activation
(GO:0043030)
Signaling receptor binding
(GO:0005102)

Other Information

Proteins

Phospholipase A2 group V
Q6GTW1_MOUSE

Genular Protein ID: 3244527202

Symbol: PA2G5_MOUSE

Name: Phospholipase A2 group V

UniProtKB Accession Codes:

P97391 Q9QZU6

Database IDs:

Citations:

PubMed ID: 8838795

Title: Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human.

PubMed ID: 8838795

DOI: 10.1006/geno.1996.0126

PubMed ID: 10531350

Title: Low molecular weight group IIA and group V phospholipase A(2) enzymes have different intracellular locations in mouse bone marrow-derived mast cells.

PubMed ID: 10531350

DOI: 10.1074/jbc.274.44.31476

PubMed ID: 11694541

Title: Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2).

PubMed ID: 11694541

DOI: 10.1074/jbc.m109699200

PubMed ID: 14962950

Title: Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation.

PubMed ID: 14962950

DOI: 10.1161/01.atv.0000122363.02961.c1

PubMed ID: 16407308

Title: Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis.

PubMed ID: 16407308

DOI: 10.1074/jbc.m508314200

PubMed ID: 19342668

Title: Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans.

PubMed ID: 19342668

DOI: 10.4049/jimmunol.0803776

PubMed ID: 20432503

Title: A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis.

PubMed ID: 20432503

DOI: 10.1002/emmm.201000072

PubMed ID: 20817863

Title: Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function.

PubMed ID: 20817863

DOI: 10.4049/jimmunol.1001384

PubMed ID: 24910243

Title: The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.

PubMed ID: 24910243

DOI: 10.1016/j.cmet.2014.05.002

PubMed ID: 29346348

Title: Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms.

PubMed ID: 29346348

DOI: 10.1038/mi.2017.99

Sequence Information:

Length: 137
Mass: 15859
Checksum: F08920E1FD1D912A
Sequence:

MKGLLTLAWF LACSVPAVPG GLLELKSMIE KVTGKNAFKN YGFYGCYCGW GGRGTPKDGT 
DWCCQMHDRC YGQLEEKDCA IRTQSYDYRY TNGLVICEHD SFCPMRLCAC DRKLVYCLRR 
NLWTYNPLYQ YYPNFLC

Genular Protein ID: 885740367

Symbol: Q6GTW1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q6GTW1 E9PZD1

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 137
Mass: 15959
Checksum: 118920E1FD0C8037
Sequence:

MKGLLTLAWF LACSVPAVPG GLLELKSMIE KVTRKNAFKN YGFYGCYCGW GGRGTPKDGT 
DWCCQMHDRC YGQLEEKDCA IRTQSYDYRY TNGLVICEHD SFCPMRLCAC DRKLVYCLRR 
NLWTYNPLYQ YYPNFLC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pla2g5

Associated with

Other Information

Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human. PubMed ID: 8838795

Low molecular weight group IIA and group V phospholipase A(2) enzymes have different intracellular locations in mouse bone marrow-derived mast cells. PubMed ID: 10531350

Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2). PubMed ID: 11694541

Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation. PubMed ID: 14962950

Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis. PubMed ID: 16407308

Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans. PubMed ID: 19342668

A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis. PubMed ID: 20432503

Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function. PubMed ID: 20817863

The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity. PubMed ID: 24910243

Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms. PubMed ID: 29346348

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303