Details for: Serpine1

Gene ID: 18787

Symbol: Serpine1

Ensembl ID: ENSMUSG00000037411

Description: serine (or cysteine) peptidase inhibitor, clade E, member 1

Associated with

  • Dissolution of fibrin clot
    (R-MMU-75205)
  • Ecm proteoglycans
    (R-MMU-3000178)
  • Extracellular matrix organization
    (R-MMU-1474244)
  • Hemostasis
    (R-MMU-109582)
  • Platelet activation, signaling and aggregation
    (R-MMU-76002)
  • Platelet degranulation
    (R-MMU-114608)
  • Response to elevated platelet cytosolic ca2+
    (R-MMU-76005)
  • Angiogenesis
    (GO:0001525)
  • Cellular response to interleukin-1
    (GO:0071347)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to transforming growth factor beta stimulus
    (GO:0071560)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Chromaffin granule
    (GO:0042583)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Dentinogenesis
    (GO:0097187)
  • Extracellular exosome
    (GO:0070062)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Female gonad development
    (GO:0008585)
  • Negative regulation of cell adhesion mediated by integrin
    (GO:0033629)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of endopeptidase activity
    (GO:0010951)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
    (GO:1902042)
  • Negative regulation of fibrinolysis
    (GO:0051918)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of peptidase activity
    (GO:0010466)
  • Negative regulation of plasminogen activation
    (GO:0010757)
  • Negative regulation of smooth muscle cell-matrix adhesion
    (GO:2000098)
  • Negative regulation of smooth muscle cell migration
    (GO:0014912)
  • Negative regulation of vascular wound healing
    (GO:0061044)
  • Peptidase inhibitor activity
    (GO:0030414)
  • Peptidase inhibitor complex
    (GO:1904090)
  • Placenta development
    (GO:0001890)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of blood coagulation
    (GO:0030194)
  • Positive regulation of calcium ion import
    (GO:0090280)
  • Positive regulation of coagulation
    (GO:0050820)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of epithelium regeneration
    (GO:1905043)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of keratinocyte migration
    (GO:0051549)
  • Positive regulation of leukotriene production involved in inflammatory response
    (GO:0035491)
  • Positive regulation of monocyte chemotaxis
    (GO:0090026)
  • Positive regulation of odontoblast differentiation
    (GO:1901331)
  • Positive regulation of receptor-mediated endocytosis
    (GO:0048260)
  • Protease binding
    (GO:0002020)
  • Protein binding
    (GO:0005515)
  • Regulation of angiogenesis
    (GO:0045765)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of signaling receptor activity
    (GO:0010469)
  • Replicative senescence
    (GO:0090399)
  • Serine-type endopeptidase inhibitor activity
    (GO:0004867)
  • Serine protease inhibitor complex
    (GO:0097180)
  • Signaling receptor binding
    (GO:0005102)

Other Information

Genular Protein ID: 3265301149

Symbol: G5E899_MOUSE

Name: N/A

UniProtKB Accession Codes:

G5E899

Database IDs:

AGR 1 ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 3 GO 25 Gene3D 2 GeneTree 1 HOGENOM 1 InterPro 6 KEGG 1 MEROPS 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 402
  • Mass: 45044
  • Checksum: 38DA027DFDF9AE3E
  • Sequence:
    • MQMSSALACL ILGLVLVSGK GFTLPLRESH TAHQATDFGV KVFQQVVQAS KDRNVVFSPY 
GVSSVLAMLQ MTTAGKTRRQ IQDAMGFKVN EKGTAHALRQ LSKELMGPWN KNEISTADAI 
FVQRDLELVQ GFMPHFFKLF QTMVKQVDFS EVERARFIIN DWVERHTKGM ISDLLAKGAV 
DELTRLVLVN ALYFSGQWKT PFLEASTHQR LFHKSDGSTV SVPMMAQSNK FNYTEFTTPD 
GLEYDVVELP YQGDTLSMFI AAPFEKDVHL SALTNILDAE LIRQWKGNMT RLPRLLILPK 
FSLETEVDLR GPLEKLGMPD MFSATLADFT SLSDQEQLSV AQALQKVRIE VNESGTVASS 
STAFVISARM APTEMVIDRS FLFVVRHNPT ETILFMGQVM EP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.