Genular: Defining Cellular Identity and Function

Details for: Plcb1

Gene ID: 18795

Symbol: Plcb1

Ensembl ID: ENSMUSG00000051177

Description: phospholipase C, beta 1

Associated with

Acetylcholine regulates insulin secretion
(R-MMU-399997)
Activation of kainate receptors upon glutamate binding
(R-MMU-451326)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
Ca2+ pathway
(R-MMU-4086398)
Fatty acids bound to gpr40 (ffar1) regulate insulin secretion
(R-MMU-434316)
Free fatty acids regulate insulin secretion
(R-MMU-400451)
G-protein beta:gamma signalling
(R-MMU-397795)
G-protein mediated events
(R-MMU-112040)
G alpha (i) signalling events
(R-MMU-418594)
G alpha (q) signalling events
(R-MMU-416476)
G beta:gamma signalling through plc beta
(R-MMU-418217)
Gpcr downstream signalling
(R-MMU-388396)
Inositol phosphate metabolism
(R-MMU-1483249)
Integration of energy metabolism
(R-MMU-163685)
Metabolism
(R-MMU-1430728)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Opioid signalling
(R-MMU-111885)
Plc beta mediated events
(R-MMU-112043)
Presynaptic function of kainate receptors
(R-MMU-500657)
Regulation of insulin secretion
(R-MMU-422356)
Signaling by gpcr
(R-MMU-372790)
Signaling by wnt
(R-MMU-195721)
Synthesis of ip3 and ip4 in the cytosol
(R-MMU-1855204)
Transmission across chemical synapses
(R-MMU-112315)
Activation of meiosis involved in egg activation
(GO:0060466)
Brain development
(GO:0007420)
Calcium ion binding
(GO:0005509)
Calmodulin binding
(GO:0005516)
Cell adhesion
(GO:0007155)
Cellular response to fluoride
(GO:1902618)
Cellular response to glyceraldehyde
(GO:1905631)
Cellular response to ionomycin
(GO:1904637)
Cellular response to vasopressin
(GO:1904117)
Cerebral cortex development
(GO:0021987)
Chromatin
(GO:0000785)
Enzyme binding
(GO:0019899)
Erythrocyte differentiation
(GO:0030218)
Fat cell differentiation
(GO:0045444)
G2/m transition of mitotic cell cycle
(GO:0000086)
Glutamate receptor signaling pathway
(GO:0007215)
G protein-coupled acetylcholine receptor signaling pathway
(GO:0007213)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtpase activator activity
(GO:0005096)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Inositol trisphosphate metabolic process
(GO:0032957)
Insulin-like growth factor receptor signaling pathway
(GO:0048009)
Insulin receptor signaling pathway
(GO:0008286)
Interleukin-1-mediated signaling pathway
(GO:0070498)
Interleukin-12-mediated signaling pathway
(GO:0035722)
Interleukin-15-mediated signaling pathway
(GO:0035723)
Intracellular signal transduction
(GO:0035556)
Ion channel modulating, g protein-coupled receptor signaling pathway
(GO:0099105)
Lamin binding
(GO:0005521)
Ligand-gated ion channel signaling pathway
(GO:1990806)
Lipid catabolic process
(GO:0016042)
Lipid metabolic process
(GO:0006629)
Macrophage differentiation
(GO:0030225)
Memory
(GO:0007613)
Mrna processing
(GO:0006397)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of monocyte extravasation
(GO:2000438)
Nucleus
(GO:0005634)
Oocyte maturation
(GO:0001556)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Phosphatidylinositol-mediated signaling
(GO:0048015)
Phosphatidylinositol catabolic process
(GO:0031161)
Phosphatidylinositol metabolic process
(GO:0046488)
Phosphatidylinositol phospholipase c activity
(GO:0004435)
Phospholipase c-activating g protein-coupled acetylcholine receptor signaling pathway
(GO:0007207)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Phosphoric diester hydrolase activity
(GO:0008081)
Positive regulation of acrosome reaction
(GO:2000344)
Positive regulation of cd24 production
(GO:2000560)
Positive regulation of developmental growth
(GO:0048639)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of embryonic development
(GO:0040019)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of myoblast differentiation
(GO:0045663)
Positive regulation of sodium:proton antiporter activity
(GO:0032417)
Postsynaptic modulation of chemical synaptic transmission
(GO:0099170)
Protein binding
(GO:0005515)
Regulation of establishment of endothelial barrier
(GO:1903140)
Regulation of fertilization
(GO:0080154)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Regulation of retrograde trans-synaptic signaling by endocanabinoid
(GO:0099178)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to monosaccharide
(GO:0034284)
Response to peptide hormone
(GO:0043434)
Signal transduction
(GO:0007165)

Other Information

Proteins

PLC-154
Q3UPW0_MOUSE

Genular Protein ID: 1124311454

Symbol: PLCB1_MOUSE

Name: PLC-154

UniProtKB Accession Codes:

Q9Z1B3 Q62075 Q6PDH1 Q8K5A5 Q8K5A6 Q9Z0E5 Q9Z2T5

Database IDs:

Citations:

PubMed ID: 11471062

Title: High-throughput sequence identification of gene coding variants within alcohol-related QTLs.

PubMed ID: 11471062

DOI: 10.1007/s00335-001-1001-x

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9753089

Title: Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain.

PubMed ID: 9753089

DOI: 10.1046/j.1460-9568.1998.00213.x

PubMed ID: 8687404

Title: Phospholipase C in mouse oocytes: characterization of beta and gamma isoforms and their possible involvement in sperm-induced Ca2+ spiking.

PubMed ID: 8687404

DOI: 10.1042/bj3160583

PubMed ID: 18802028

Title: Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes.

PubMed ID: 18802028

DOI: 10.1161/circresaha.108.176024

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 27653213

Title: Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome.

PubMed ID: 27653213

DOI: 10.1038/ncomms12823

Sequence Information:

Length: 1216
Mass: 138396
Checksum: CC751D49895A47D0
Sequence:

MAGAQPGVHA LQLKPVCVSD SLKKGTKFVK WDDDSTIVTP IILRTDPQGF FFYWTDQNKE 
TELLDLSLVK DARCGKHAKA PKDPKLRELL DVGNIGHLEQ RMITVVYGPD LVNISHLNLV 
AFQEEVAKEW TNEVFSLATN LLAQNMSRDA FLEKAYTKLK LQVTPEGRIP LKNIYRLFSA 
DRKRVETALE ACSLPSSRND SIPQEDFTPD VYRVFLNNLC PRPEIDNIFS EFGAKSKPYL 
TVDQMMDFIN LKQRDPRLNE ILYPPLKQEQ VQVLIEKYEP NSSLAKKGQM SVDGFMRYLS 
GEENGVVSPE KLDLNEDMSQ PLSHYFINSS HNTYLTAGQL AGNSSVEMYR QVLLSGCRCV 
ELDCWKGRTA EEEPVITHGF TMTTEISFKE VIEAIAECAF KTSPFPILLS FENHVDSPKQ 
QAKMAEYCRL IFGDALLMEP LEKYPLESGV PLPSPMDLMY KILVKNKKKS HKSSEGSGKK 
KLSEQASNTY SDSSSVFEPS SPGAGEADTE SDDDDDDDDC KKSSMDEGTA GSEAMATEEM 
SNLVNYIQPV KFESFEISKK RNKSFEMSSF VETKGLEQLT KSPVEFVEYN KMQLSRIYPK 
GTRVDSSNYM PQLFWNAGCQ MVALNFQTVD LAMQINMGMY EYNGKSGYRL KPEFMRRPDK 
HFDPFTEGIV DGIVANTLSV KIISGQFLSD KKVGTYVEVD MFGLPVDTRR KAFKTKTSQG 
NAVNPVWEEE PIVFKKVVLP SLACLRIAAY EEGGKFIGHR ILPVQAIRPG YHYICLRNER 
NQPLTLPAVF VYIEVKDYVP DTYADVIEAL SNPIRYVNLM EQRAKQLAAL TLEDEEEVKK 
EADPGETSSE APSETRTTPA ENGVNHTASL APKPPSQAPH SQPAPGSVKA PAKTEDLIQS 
VLTEVEAQTI EELKQQKSFV KLQKKHYKEM KDLVKRHHKK TTELIKEHTT KYNEIQNDYL 
RRRAALEKSA KKDSKKKSEP SSPDHGSSAI EQDLAALDAE MTQKLIDLKD KQQQQLLNLR 
QEQYYSEKYQ KREHIKLLIQ KLTDVAEECQ NNQLKKLKEI CEKEKKELKK KMDKKRQEKI 
TEAKSKDKSQ MEEEKTEMIR SYIQEVVQYI KRLEEAQSKR QEKLVEKHNE IRQQILDEKP 
KLQTELEQEY QDKFKRLPLE ILEFVQEAMK GKISEDSNHG SAPPSLASDA AKVNLKSPSS 
EEIERENPGR EFDTPL

Genular Protein ID: 173368645

Symbol: Q3UPW0_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UPW0

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 558
Mass: 62696
Checksum: 8334CCFD7491C7F0
Sequence:

MAGAQPGVHA LQLKPVCVSD SLKKGTKFVK WDDDSTIVTP IILRTDPQGF FFYWTDQNKE 
TELLDLSLVK DARCGKHAKA PKDPKLRELL DVGNIGHLEQ RMITVVYGPD LVNISHLNLV 
AFQEEVAKEW TNEVFSLATN LLAQNMSRDA FLEKAYTKLK LQVTPEGRIP LKNIYRLFSA 
DRKRVETALE ACSLPSSRND SIPQEDFTPD VYRVFLNNLC PRPEIDNIFS EFGAKSKPYL 
TVDQMMDFIN LKQRDPRLNE ILYPPLKQEQ VQVLIEKYEP NSSLAKKGQM SVDGFMRYLS 
GEENGVVSPE KLDLNEDMSQ PLSHYFINSS HNTYLTAGQL AGNSSVEMYR QVLLSGCRCV 
ELDCWKGRTA EEEPVITHGF TMTTEISFKE VIEAIAECAF KTSPFPILLS FENHVDSPKQ 
QAKMAEYCRL IFGDALLMEP LEKYPLESGV PLPSPMDLMY KILVKNKKKS HKSSEGSGKK 
KLSEQASNTY SDSSSVFEPS SPGAGEADTE SDDDDDDDDC KKSSMDEGTA GSEAMATEEM 
SNLVNYIQPV KFESFEIP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Plcb1

Associated with

Other Information

High-throughput sequence identification of gene coding variants within alcohol-related QTLs. PubMed ID: 11471062

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain. PubMed ID: 9753089

Phospholipase C in mouse oocytes: characterization of beta and gamma isoforms and their possible involvement in sperm-induced Ca2+ spiking. PubMed ID: 8687404

Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes. PubMed ID: 18802028

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome. PubMed ID: 27653213

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073