Genular: Defining Cellular Identity and Function

Details for: Plk1

Gene ID: 18817

Symbol: Plk1

Ensembl ID: ENSMUSG00000030867

Description: polo like kinase 1

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176814)
Activation of nima kinases nek9, nek6, nek7
(R-MMU-2980767)
Amplification of signal from the kinetochores
(R-MMU-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-MMU-141444)
Anchoring of the basal body to the plasma membrane
(R-MMU-5620912)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-MMU-174178)
Aurka activation by tpx2
(R-MMU-8854518)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Centrosome maturation
(R-MMU-380287)
Cilium assembly
(R-MMU-5617833)
Condensation of prophase chromosomes
(R-MMU-2299718)
Cyclin a/b1/b2 associated events during g2/m transition
(R-MMU-69273)
Eml4 and nudc in mitotic spindle formation
(R-MMU-9648025)
G2/m transition
(R-MMU-69275)
Golgi cisternae pericentriolar stack reorganization
(R-MMU-162658)
Loss of nlp from mitotic centrosomes
(R-MMU-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-MMU-380284)
Mitotic anaphase
(R-MMU-68882)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic metaphase/anaphase transition
(R-MMU-68881)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prometaphase
(R-MMU-68877)
Mitotic prophase
(R-MMU-68875)
Mitotic spindle checkpoint
(R-MMU-69618)
Mitotic telophase/cytokinesis
(R-MMU-68884)
M phase
(R-MMU-68886)
Nuclear envelope breakdown
(R-MMU-2980766)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Phosphorylation of emi1
(R-MMU-176417)
Phosphorylation of the apc/c
(R-MMU-176412)
Polo-like kinase mediated events
(R-MMU-156711)
Recruitment of mitotic centrosome proteins and complexes
(R-MMU-380270)
Recruitment of numa to mitotic centrosomes
(R-MMU-380320)
Regulation of apc/c activators between g1/s and early anaphase
(R-MMU-176408)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Resolution of sister chromatid cohesion
(R-MMU-2500257)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Separation of sister chromatids
(R-MMU-2467813)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-MMU-8852276)
Anaphase-promoting complex binding
(GO:0010997)
Atp binding
(GO:0005524)
Cell cycle
(GO:0007049)
Centrosome cycle
(GO:0007098)
Double-strand break repair
(GO:0006302)
Establishment of mitotic spindle orientation
(GO:0000132)
Establishment of protein localization
(GO:0045184)
Female meiosis chromosome segregation
(GO:0016321)
G2/m transition of mitotic cell cycle
(GO:0000086)
Homologous chromosome segregation
(GO:0045143)
Identical protein binding
(GO:0042802)
Kinase activity
(GO:0016301)
Magnesium ion binding
(GO:0000287)
Microtubule binding
(GO:0008017)
Microtubule bundle formation
(GO:0001578)
Mitotic cell cycle
(GO:0000278)
Mitotic cytokinesis
(GO:0000281)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Mitotic sister chromatid segregation
(GO:0000070)
Mitotic spindle assembly checkpoint signaling
(GO:0007094)
Mitotic spindle organization
(GO:0007052)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045736)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear membrane disassembly
(GO:0051081)
Nucleotide binding
(GO:0000166)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphorylation
(GO:0016310)
Polar body extrusion after meiotic divisions
(GO:0040038)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of proteolysis
(GO:0045862)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein localization to organelle
(GO:0033365)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein ubiquitination
(GO:0016567)
Regulation of cytokinesis
(GO:0032465)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of mitotic metaphase/anaphase transition
(GO:0030071)
Regulation of protein binding
(GO:0043393)
Transferase activity
(GO:0016740)

Other Information

Proteins

Serine/threonine-protein kinase PLK1

Genular Protein ID: 1991784513

Symbol: PLK1_MOUSE

Name: Serine/threonine-protein kinase PLK1

UniProtKB Accession Codes:

Q07832

Database IDs:

Citations:

PubMed ID: 8099445

Title: Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila.

PubMed ID: 8099445

DOI: 10.1073/pnas.90.11.4882

PubMed ID: 8018557

Title: Cloning and characterization of human and murine homologues of the Drosophila polo serine-threonine kinase.

PubMed ID: 8018557

PubMed ID: 7902533

Title: Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase.

PubMed ID: 7902533

DOI: 10.1128/mcb.13.12.7793-7801.1993

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9154840

Title: Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures.

PubMed ID: 9154840

DOI: 10.1128/mcb.17.6.3408

PubMed ID: 18794363

Title: Polo-like kinase 1 is essential for early embryonic development and tumor suppression.

PubMed ID: 18794363

DOI: 10.1128/mcb.00392-08

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22753416

Title: Furry protein promotes Aurora A-mediated polo-like kinase 1 activation.

PubMed ID: 22753416

DOI: 10.1074/jbc.m112.378968

PubMed ID: 22405274

Title: Tex14, a plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint.

PubMed ID: 22405274

DOI: 10.1016/j.molcel.2012.01.013

PubMed ID: 27979967

Title: DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.

PubMed ID: 27979967

DOI: 10.1074/jbc.m116.765438

PubMed ID: 25533956

Title: Meikin is a conserved regulator of meiosis-I-specific kinetochore function.

PubMed ID: 25533956

DOI: 10.1038/nature14097

PubMed ID: 29191835

Title: Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions.

PubMed ID: 29191835

DOI: 10.1074/jbc.m117.802587

Sequence Information:

Length: 603
Mass: 68301
Checksum: 1B980646366EFA10
Sequence:

MNAAAKAGKL ARAPADLGKG GVPGDAVPGA PVAAPLAKEI PEVLVDPRSR RQYVRGRFLG 
KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQKEKMSM EISIHRSLAH QHVVGFHDFF 
EDSDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN QVIHRDLKLG 
NLFLNEDLEV KIGDFGLATK VEYEGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI 
MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP TARPTIHELL 
NDEFFTSGYI PARLPITCLT IPPRFSIAPS SLDPSSRKPL KVLNKGVENP LPDRPREKEE 
PVVRETNEAI ECHLSDLLQQ LTSVNASKPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK 
YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGTE SYLTVSSHPN SLMKKITLLN 
YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGTV QINFFQDHTK 
LILCPLMAAV TYINEKRDFQ TYRLSLLEEY GCCKELASRL RYARTMVDKL LSSRSASNRL 
KAS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Plk1

Associated with

Other Information

Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila. PubMed ID: 8099445

Cloning and characterization of human and murine homologues of the Drosophila polo serine-threonine kinase. PubMed ID: 8018557

Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase. PubMed ID: 7902533

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures. PubMed ID: 9154840

Polo-like kinase 1 is essential for early embryonic development and tumor suppression. PubMed ID: 18794363

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Furry protein promotes Aurora A-mediated polo-like kinase 1 activation. PubMed ID: 22753416

Tex14, a plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint. PubMed ID: 22405274

DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle. PubMed ID: 27979967

Meikin is a conserved regulator of meiosis-I-specific kinetochore function. PubMed ID: 25533956

Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions. PubMed ID: 29191835