Details for: Pln

Gene ID: 18821

Symbol: Pln

Ensembl ID: ENSMUSG00000038583

Description: phospholamban

Associated with

  • Cardiac conduction
    (R-MMU-5576891)
  • Ion channel transport
    (R-MMU-983712)
  • Ion homeostasis
    (R-MMU-5578775)
  • Ion transport by p-type atpases
    (R-MMU-936837)
  • Muscle contraction
    (R-MMU-397014)
  • Transport of small molecules
    (R-MMU-382551)
  • Acrosome assembly
    (GO:0001675)
  • Adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
    (GO:0086023)
  • Atpase inhibitor activity
    (GO:0042030)
  • Calcium ion-transporting atpase complex
    (GO:0090534)
  • Calcium ion transport
    (GO:0006816)
  • Cardiac muscle tissue development
    (GO:0048738)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Identical protein binding
    (GO:0042802)
  • Intracellular calcium ion homeostasis
    (GO:0006874)
  • Membrane
    (GO:0016020)
  • Mitochondrion
    (GO:0005739)
  • Muscle cell cellular homeostasis
    (GO:0046716)
  • Negative regulation of atp-dependent activity
    (GO:0032780)
  • Negative regulation of atpase-coupled calcium transmembrane transporter activity
    (GO:1901895)
  • Negative regulation of calcium ion binding
    (GO:1901877)
  • Negative regulation of calcium ion import into sarcoplasmic reticulum
    (GO:1902081)
  • Negative regulation of calcium ion transmembrane transporter activity
    (GO:1901020)
  • Negative regulation of calcium ion transport
    (GO:0051926)
  • Negative regulation of heart contraction
    (GO:0045822)
  • Negative regulation of heart rate
    (GO:0010459)
  • Notch signaling pathway
    (GO:0007219)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of atpase-coupled calcium transmembrane transporter activity
    (GO:1901894)
  • Regulation of calcium ion import
    (GO:0090279)
  • Regulation of calcium ion transport
    (GO:0051924)
  • Regulation of cardiac muscle cell contraction
    (GO:0086004)
  • Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
    (GO:0010881)
  • Regulation of heart contraction
    (GO:0008016)
  • Regulation of relaxation of muscle
    (GO:1901077)
  • Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
    (GO:0010880)
  • Regulation of ryanodine-sensitive calcium-release channel activity
    (GO:0060314)
  • Regulation of the force of heart contraction
    (GO:0002026)
  • Regulation of the force of heart contraction by cardiac conduction
    (GO:0086092)
  • Response to testosterone
    (GO:0033574)
  • Response to zinc ion
    (GO:0010043)
  • Sarcoplasmic reticulum
    (GO:0016529)
  • Sarcoplasmic reticulum membrane
    (GO:0033017)
  • Vesicle
    (GO:0031982)

Other Information

Genular Protein ID: 229518924

Symbol: PPLA_MOUSE

Name: N/A

UniProtKB Accession Codes:

P61014 P20006 Q3UQ75

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 EMBL 6 Ensembl 6 GO 34 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MGI 2 NCBI Taxonomy 1 NCBIfam 1 OMA 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1394867

Title: Mouse phospholamban gene expression during development in vivo and in vitro.

PubMed ID: 1394867

DOI: 10.1161/01.res.71.5.1021

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22971924

Title: Tuning the structural coupling between the transmembrane and cytoplasmic domains of phospholamban to control sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) function.

PubMed ID: 22971924

DOI: 10.1007/s10974-012-9319-4

PubMed ID: 20890288

Title: Dynamics connect substrate recognition to catalysis in protein kinase A.

PubMed ID: 20890288

DOI: 10.1038/nchembio.452

PubMed ID: 26644582

Title: Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy.

PubMed ID: 26644582

DOI: 10.1073/pnas.1518368112

PubMed ID: 26816378

Title: Muscle physiology. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle.

PubMed ID: 26816378

DOI: 10.1126/science.aad4076

PubMed ID: 30733280

Title: The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.

PubMed ID: 30733280

DOI: 10.15252/embr.201846449

Sequence Information:

  • Length: 52
  • Mass: 6095
  • Checksum: 0763601F76A854D3
  • Sequence:
    • MEKVQYLTRS AIRRASTIEM PQQARQNLQN LFINFCLILI CLLLICIIVM LL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.