Genular: Defining Cellular Identity and Function

Details for: Ccl21a

Gene ID: 18829

Symbol: Ccl21a

Ensembl ID: ENSMUSG00000094686

Description: C-C motif chemokine ligand 21 (serine)

Associated with

Chemokine receptors bind chemokines
(R-MMU-380108)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Ccr7 chemokine receptor binding
(GO:0031732)
Ccr chemokine receptor binding
(GO:0048020)
Cell chemotaxis
(GO:0060326)
Cell maturation
(GO:0048469)
Cellular response to chemokine
(GO:1990869)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to type ii interferon
(GO:0071346)
Chemokine (c-c motif) ligand 21 signaling pathway
(GO:0038116)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine activity
(GO:0008009)
Chemokine receptor binding
(GO:0042379)
Chemotaxis
(GO:0006935)
Cytokine activity
(GO:0005125)
Dendritic cell chemotaxis
(GO:0002407)
Dendritic cell dendrite assembly
(GO:0097026)
Establishment of t cell polarity
(GO:0001768)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
G protein-coupled receptor signaling pathway
(GO:0007186)
Immune response
(GO:0006955)
Immunological synapse formation
(GO:0001771)
Induction of positive chemotaxis
(GO:0050930)
Inflammatory response
(GO:0006954)
Killing of cells of another organism
(GO:0031640)
Lymph node development
(GO:0048535)
Lymphocyte chemotaxis
(GO:0048247)
Mesangial cell-matrix adhesion
(GO:0035759)
Monocyte chemotaxis
(GO:0002548)
Negative regulation of dendritic cell apoptotic process
(GO:2000669)
Negative regulation of dendritic cell dendrite assembly
(GO:2000548)
Negative regulation of leukocyte tethering or rolling
(GO:1903237)
Neutrophil chemotaxis
(GO:0030593)
Positive regulation of actin filament polymerization
(GO:0030838)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of cell adhesion mediated by integrin
(GO:0033630)
Positive regulation of cell motility
(GO:2000147)
Positive regulation of chemotaxis
(GO:0050921)
Positive regulation of dendritic cell antigen processing and presentation
(GO:0002606)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of filopodium assembly
(GO:0051491)
Positive regulation of glycoprotein biosynthetic process
(GO:0010560)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of myeloid dendritic cell chemotaxis
(GO:2000529)
Positive regulation of neutrophil chemotaxis
(GO:0090023)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of pseudopodium assembly
(GO:0031274)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Positive regulation of t cell chemotaxis
(GO:0010820)
Positive regulation of t cell migration
(GO:2000406)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to prostaglandin e
(GO:0034695)
Ruffle organization
(GO:0031529)
T cell costimulation
(GO:0031295)

Other Information

Proteins

C-C motif chemokine 21a

Genular Protein ID: 1068326348

Symbol: CC21A_MOUSE

Name: C-C motif chemokine 21a

UniProtKB Accession Codes:

P84444 O09002 O09006 Q3U1J2 Q91V84

Database IDs:

Citations:

PubMed ID: 9257816

Title: Identification and characterization of a novel beta chemokine containing six conserved cysteines.

PubMed ID: 9257816

PubMed ID: 9548511

Title: Identification of a new mouse beta-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells.

PubMed ID: 9548511

PubMed ID: 10523616

Title: The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes.

PubMed ID: 10523616

DOI: 10.1084/jem.190.8.1183

PubMed ID: 11123313

Title: Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation.

PubMed ID: 11123313

DOI: 10.4049/jimmunol.166.1.361

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9419363

Title: A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.

PubMed ID: 9419363

DOI: 10.1073/pnas.95.1.258

PubMed ID: 31875850

Title: A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity.

PubMed ID: 31875850

DOI: 10.1038/s41586-019-1873-0

Sequence Information:

Length: 133
Mass: 14558
Checksum: ABD2750A320B3719
Sequence:

MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK QEPSLGCPIP 
AILFSPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS PGCRKNRGTS KSGKKGKGSK 
GCKRTEQTQP SRG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ccl21a

Associated with

Other Information

Identification and characterization of a novel beta chemokine containing six conserved cysteines. PubMed ID: 9257816

Identification of a new mouse beta-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells. PubMed ID: 9548511

The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes. PubMed ID: 10523616

Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. PubMed ID: 11123313

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. PubMed ID: 9419363

A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity. PubMed ID: 31875850