Details for: AGXT
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hepatoblast (CL0005026)
Fold Change: 11.6515
Cell Significance Index: 195.9700 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 9.4691
Cell Significance Index: 141.6700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 5.1974
Cell Significance Index: 87.5500 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 4.5189
Cell Significance Index: 91.9500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 3.4642
Cell Significance Index: 102.0400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 2.9061
Cell Significance Index: 178.1700 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 2.1918
Cell Significance Index: 8.2600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.2676
Cell Significance Index: 18.7100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0490
Cell Significance Index: 208.1700 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.8655
Cell Significance Index: 6.6500 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.8448
Cell Significance Index: 4.8700 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 0.6899
Cell Significance Index: 1.8200 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.5676
Cell Significance Index: 5.6000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5169
Cell Significance Index: 31.0300 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.5103
Cell Significance Index: 12.3600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4522
Cell Significance Index: 408.3400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4256
Cell Significance Index: 46.2900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.3771
Cell Significance Index: 5.4000 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: 0.3500
Cell Significance Index: 6.9800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3129
Cell Significance Index: 50.8900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.2695
Cell Significance Index: 9.4400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2379
Cell Significance Index: 23.5300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2301
Cell Significance Index: 15.9200 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.2145
Cell Significance Index: 2.7600 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.1624
Cell Significance Index: 0.4400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1445
Cell Significance Index: 6.5500 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.1254
Cell Significance Index: 1.8200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1059
Cell Significance Index: 3.0400 - Cell Name: precursor cell (CL0011115)
Fold Change: 0.1002
Cell Significance Index: 0.7600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0767
Cell Significance Index: 2.2100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0762
Cell Significance Index: 1.6500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0730
Cell Significance Index: 13.9000 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.0589
Cell Significance Index: 0.5600 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.0475
Cell Significance Index: 0.3800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0310
Cell Significance Index: 0.8300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0291
Cell Significance Index: 0.6200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0202
Cell Significance Index: 0.7100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0111
Cell Significance Index: 0.1200 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.0101
Cell Significance Index: 0.0400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0097
Cell Significance Index: 1.1100 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.0054
Cell Significance Index: 0.0700 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.0015
Cell Significance Index: 0.0200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0012
Cell Significance Index: -2.2300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0026
Cell Significance Index: -1.4800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0027
Cell Significance Index: -1.9700 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0028
Cell Significance Index: -1.5300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0044
Cell Significance Index: -0.3500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0045
Cell Significance Index: -0.5200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0052
Cell Significance Index: -0.2100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0060
Cell Significance Index: -2.1600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0064
Cell Significance Index: -4.7100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0077
Cell Significance Index: -1.5400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0088
Cell Significance Index: -3.9900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0090
Cell Significance Index: -1.5300 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0094
Cell Significance Index: -0.1300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0096
Cell Significance Index: -2.0300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0124
Cell Significance Index: -0.3500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0143
Cell Significance Index: -0.3900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0150
Cell Significance Index: -0.4000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0153
Cell Significance Index: -2.1100 - Cell Name: ependymal cell (CL0000065)
Fold Change: -0.0157
Cell Significance Index: -0.1900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0161
Cell Significance Index: -2.0800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0164
Cell Significance Index: -0.4100 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0200
Cell Significance Index: -0.3500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0213
Cell Significance Index: -2.2200 - Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.0230
Cell Significance Index: -0.2300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0238
Cell Significance Index: -1.5000 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.0240
Cell Significance Index: -0.2900 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.0249
Cell Significance Index: -0.2600 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0265
Cell Significance Index: -0.3800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0268
Cell Significance Index: -0.5600 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0285
Cell Significance Index: -0.4300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0290
Cell Significance Index: -2.1700 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.0322
Cell Significance Index: -0.4200 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0331
Cell Significance Index: -0.3600 - Cell Name: erythroblast (CL0000765)
Fold Change: -0.0352
Cell Significance Index: -0.4200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0367
Cell Significance Index: -5.3300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0367
Cell Significance Index: -2.4700 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0370
Cell Significance Index: -0.6100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0371
Cell Significance Index: -1.9500 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0377
Cell Significance Index: -0.9400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0382
Cell Significance Index: -1.2500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0390
Cell Significance Index: -3.9800 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0399
Cell Significance Index: -0.3100 - Cell Name: tendon cell (CL0000388)
Fold Change: -0.0419
Cell Significance Index: -0.5700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0451
Cell Significance Index: -2.1200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0452
Cell Significance Index: -1.4400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0453
Cell Significance Index: -1.4500 - Cell Name: deuterosomal cell (CL4033044)
Fold Change: -0.0459
Cell Significance Index: -0.3600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0460
Cell Significance Index: -0.6900 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0474
Cell Significance Index: -0.8200 - Cell Name: myelocyte (CL0002193)
Fold Change: -0.0477
Cell Significance Index: -0.5100 - Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.0481
Cell Significance Index: -0.4300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0483
Cell Significance Index: -2.5100 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.0495
Cell Significance Index: -0.5400 - Cell Name: plasmablast (CL0000980)
Fold Change: -0.0501
Cell Significance Index: -0.4700 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.0507
Cell Significance Index: -0.5600 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.0514
Cell Significance Index: -0.5300 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.0529
Cell Significance Index: -0.5500 - Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.0535
Cell Significance Index: -0.4900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1927770238
Symbol: AGT1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2253628
Title: Cloning and nucleotide sequence of cDNA encoding human liver serine-pyruvate aminotransferase.
PubMed ID: 2253628
PubMed ID: 1703535
Title: Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1.
PubMed ID: 1703535
PubMed ID: 2363689
Title: Human peroxisomal L-alanine: glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon.
PubMed ID: 2363689
DOI: 10.1042/bj2680517
PubMed ID: 2045108
Title: Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase.
PubMed ID: 2045108
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10347152
Title: Flux of the L-serine metabolism in rabbit, human, and dog livers. Substantial contributions of both mitochondrial and peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase.
PubMed ID: 10347152
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 12899834
Title: Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1.
PubMed ID: 12899834
PubMed ID: 2039493
Title: Primary hyperoxaluria type I due to a point mutation of T to C in the coding region of the serine:pyruvate aminotransferase gene.
PubMed ID: 2039493
PubMed ID: 1349575
Title: A glycine-to-glutamate substitution abolishes alanine:glyoxylate aminotransferase catalytic activity in a subset of patients with primary hyperoxaluria type 1.
PubMed ID: 1349575
PubMed ID: 1301173
Title: A serine-to-phenylalanine substitution leads to loss of alanine:glyoxylate aminotransferase catalytic activity and immunoreactivity in a patient with primary hyperoxaluria type 1.
PubMed ID: 1301173
DOI: 10.1093/hmg/1.8.643
PubMed ID: 8101040
Title: Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation.
PubMed ID: 8101040
PubMed ID: 8507692
Title: Primary hyperoxaluria type 1 and peroxisome-to-mitochondrion mistargeting of alanine:glyoxylate aminotransferase.
PubMed ID: 8507692
PubMed ID: 9192270
Title: Primary hyperoxaluria type 1: a cluster of new mutations in exon 7 of the AGXT gene.
PubMed ID: 9192270
DOI: 10.1136/jmg.34.6.489
PubMed ID: 9604803
Title: Identification of new mutations in primary hyperoxaluria type 1 (PH1).
PubMed ID: 9604803
PubMed ID: 10394939
Title: Gene symbol: AGXT. Disease: primary hyperoxaluria type I.
PubMed ID: 10394939
PubMed ID: 10453743
Title: Molecular analysis of hyperoxaluria type 1 in Italian patients reveals eight new mutations in the alanine: glyoxylate aminotransferase gene.
PubMed ID: 10453743
PubMed ID: 10541294
Title: Primary hyperoxaluria type I: a model for multiple mutations in a monogenic disease within a distinct ethnic group.
PubMed ID: 10541294
PubMed ID: 10862087
Title: Identification of 5 novel mutations in the AGXT gene.
PubMed ID: 10862087
DOI: 10.1002/1098-1004(200006)15:6<577::aid-humu9>3.0.co;2-#
PubMed ID: 10960483
Title: Functional synergism between the most common polymorphism in human alanine:glyoxylate aminotransferase and four of the most common disease-causing mutations.
PubMed ID: 10960483
PubMed ID: 12559847
Title: The AGT gene in Africa: a distinctive minor allele haplotype, a polymorphism (V326I), and a novel PH1 mutation (A112D) in Black Africans.
PubMed ID: 12559847
PubMed ID: 12777626
Title: Primary hyperoxaluria type 1 in the Canary Islands: a conformational disease due to I244T mutation in the P11L-containing alanine:glyoxylate aminotransferase.
PubMed ID: 12777626
PubMed ID: 15253729
Title: Clinical implications of mutation analysis in primary hyperoxaluria type 1.
PubMed ID: 15253729
PubMed ID: 15849466
Title: Implications of genotype and enzyme phenotype in pyridoxine response of patients with type I primary hyperoxaluria.
PubMed ID: 15849466
DOI: 10.1159/000085411
PubMed ID: 15961946
Title: Intra-familial clinical heterogeneity: absence of genotype-phenotype correlation in primary hyperoxaluria type 1 in Israel.
PubMed ID: 15961946
DOI: 10.1159/000086357
PubMed ID: 15963748
Title: The major allele of the alanine:glyoxylate aminotransferase gene: nine novel mutations and polymorphisms associated with primary hyperoxaluria type 1.
PubMed ID: 15963748
PubMed ID: 16971151
Title: Consequences of missense mutations for dimerization and turnover of alanine:glyoxylate aminotransferase: study of a spectrum of mutations.
PubMed ID: 16971151
PubMed ID: 17495019
Title: Selected exonic sequencing of the AGXT gene provides a genetic diagnosis in 50% of patients with primary hyperoxaluria type 1.
PubMed ID: 17495019
PubMed ID: 24055001
Title: Gly161 mutations associated with primary hyperoxaluria type I induce the cytosolic aggregation and the intracellular degradation of the apo-form of alanine:glyoxylate aminotransferase.
PubMed ID: 24055001
PubMed ID: 23229545
Title: Four of the most common mutations in primary hyperoxaluria type 1 unmask the cryptic mitochondrial targeting sequence of alanine:glyoxylate aminotransferase encoded by the polymorphic minor allele.
PubMed ID: 23229545
PubMed ID: 24934730
Title: Mutational analysis of AGXT in two Chinese families with primary hyperoxaluria type 1.
PubMed ID: 24934730
PubMed ID: 26149463
Title: Misfolding caused by the pathogenic mutation G47R on the minor allele of alanine:glyoxylate aminotransferase and chaperoning activity of pyridoxine.
PubMed ID: 26149463
Sequence Information:
- Length: 392
- Mass: 43010
- Checksum: 2987DDE85B2470B4
- Sequence:
MASHKLLVTP PKALLKPLSI PNQLLLGPGP SNLPPRIMAA GGLQMIGSMS KDMYQIMDEI KEGIQYVFQT RNPLTLVISG SGHCALEAAL VNVLEPGDSF LVGANGIWGQ RAVDIGERIG ARVHPMTKDP GGHYTLQEVE EGLAQHKPVL LFLTHGESST GVLQPLDGFG ELCHRYKCLL LVDSVASLGG TPLYMDRQGI DILYSGSQKA LNAPPGTSLI SFSDKAKKKM YSRKTKPFSF YLDIKWLANF WGCDDQPRMY HHTIPVISLY SLRESLALIA EQGLENSWRQ HREAAAYLHG RLQALGLQLF VKDPALRLPT VTTVAVPAGY DWRDIVSYVI DHFDIEIMGG LGPSTGKVLR IGLLGCNATR ENVDRVTEAL RAALQHCPKK KL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.