Details for: Prrx1

Gene ID: 18933

Symbol: Prrx1

Ensembl ID: ENSMUSG00000026586

Description: paired related homeobox 1

Associated with

  • Artery morphogenesis
    (GO:0048844)
  • Cartilage development
    (GO:0051216)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Embryonic cranial skeleton morphogenesis
    (GO:0048701)
  • Embryonic limb morphogenesis
    (GO:0030326)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Hmg box domain binding
    (GO:0071837)
  • Inner ear morphogenesis
    (GO:0042472)
  • Mesenchymal cell proliferation
    (GO:0010463)
  • Middle ear morphogenesis
    (GO:0042474)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuronal stem cell population maintenance
    (GO:0097150)
  • Neuron fate determination
    (GO:0048664)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of mesenchymal cell proliferation
    (GO:0002053)
  • Positive regulation of smoothened signaling pathway
    (GO:0045880)
  • Positive regulation of stem cell proliferation
    (GO:2000648)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of neuron projection regeneration
    (GO:0070570)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii general transcription initiation factor activity
    (GO:0016251)
  • Roof of mouth development
    (GO:0060021)
  • Smoothened signaling pathway
    (GO:0007224)
  • Stem cell proliferation
    (GO:0072089)

Other Information

Genular Protein ID: 3105803808

Symbol: PRRX1_MOUSE

Name: Paired mesoderm homeobox protein 1

UniProtKB Accession Codes:

P63013 P43271 Q02810 Q569N6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 31 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 1360403

Title: MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer.

PubMed ID: 1360403

DOI: 10.1242/dev.115.4.1087

PubMed ID: 7910581

Title: Genomic organization and chromosome localization of the murine homeobox gene Pmx.

PubMed ID: 7910581

DOI: 10.1006/geno.1994.1066

PubMed ID: 1383943

Title: A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy.

PubMed ID: 1383943

DOI: 10.1093/nar/20.19.5189

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11373278

Title: The identification of Prx1 transcription regulatory domains provides a mechanism for unequal compensation by the Prx1 and Prx2 loci.

PubMed ID: 11373278

DOI: 10.1074/jbc.m100239200

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 35589735

Title: PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression.

PubMed ID: 35589735

DOI: 10.1038/s41467-022-30484-4

PubMed ID: 36456880

Title: Prrx1 marks stem cells for bone, white adipose tissue and dermis in adult mice.

PubMed ID: 36456880

DOI: 10.1038/s41588-022-01227-4

Sequence Information:

  • Length: 245
  • Mass: 27269
  • Checksum: FF867F0D856E1115
  • Sequence:
    • MTSSYGHVLE RQPALGGRLD SPGNLDTLQA KKNFSVSHLL DLEEAGDMVA AQADESVGEA 
GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD 
AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAMLANK NASLLKSYSG DVTAVEQPIV 
PRPAPRPTDY LSWGTASPYS AMATYSATCA NNSPAQGINM ANSIANLRLK AKEYSLQRNQ 
VPTVN

Genular Protein ID: 23731387

Symbol: G3UZ44_MOUSE

Name: N/A

UniProtKB Accession Codes:

G3UZ44

Database IDs:

AGR 1 ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InterPro 4 MGI 2 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

Sequence Information:

  • Length: 200
  • Mass: 22530
  • Checksum: 900D46340DE48FBB
  • Sequence:
    • MTSSYGHVLE RQPALGGRLD SPGNLDTLQA KKNFSVSHLL DLEEAGDMVA AQADESVGEA 
GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD 
AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAMLANK NASLLKSYSG DVTAVEQPIV 
PRPAPRPTDY LSWGTASPYR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.