Details for: Phox2b

Gene ID: 18935

Symbol: Phox2b

Ensembl ID: ENSMUSG00000012520

Description: paired-like homeobox 2b

Associated with

  • Autonomic nervous system development
    (GO:0048483)
  • Cell development
    (GO:0048468)
  • Cell differentiation in hindbrain
    (GO:0021533)
  • Cell population proliferation
    (GO:0008283)
  • Cellular response to bmp stimulus
    (GO:0071773)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dopaminergic neuron differentiation
    (GO:0071542)
  • Efferent axon development in a lateral line nerve
    (GO:0048894)
  • Enteric nervous system development
    (GO:0048484)
  • Glial cell differentiation
    (GO:0010001)
  • Hindbrain tangential cell migration
    (GO:0021934)
  • Inner ear development
    (GO:0048839)
  • Medullary reticular formation development
    (GO:0021723)
  • Motor neuron migration
    (GO:0097475)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of type b pancreatic cell proliferation
    (GO:1904691)
  • Neural crest cell migration involved in autonomic nervous system development
    (GO:1901166)
  • Neuron differentiation
    (GO:0030182)
  • Noradrenergic neuron development
    (GO:0003358)
  • Noradrenergic neuron differentiation
    (GO:0003357)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Parasympathetic nervous system development
    (GO:0048486)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of respiratory gaseous exchange by nervous system process
    (GO:0002087)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Respiratory system development
    (GO:0060541)
  • Retrotrapezoid nucleus neuron differentiation
    (GO:0061452)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal muscle cell differentiation
    (GO:0035914)
  • Sympathetic ganglion development
    (GO:0061549)
  • Sympathetic nervous system development
    (GO:0048485)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Other Information

Genular Protein ID: 411753364

Symbol: PHX2B_MOUSE

Name: Paired mesoderm homeobox protein 2B

UniProtKB Accession Codes:

O35690

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 44 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 9374403

Title: Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis.

PubMed ID: 9374403

DOI: 10.1242/dev.124.20.4065

PubMed ID: 10395798

Title: Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation.

PubMed ID: 10395798

DOI: 10.1006/geno.1999.5845

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18275850

Title: Trim11 increases expression of dopamine beta-hydroxylase gene by interacting with Phox2b.

PubMed ID: 18275850

DOI: 10.1016/j.bbrc.2008.01.165

Sequence Information:

  • Length: 314
  • Mass: 31621
  • Checksum: 40737F71948B595A
  • Sequence:
    • MYKMEYSYLN SSAYESCMAG MDTSSLASAY ADFSSCSQAS GFQYNPIRTT FGATSGCPSL 
TPGSCSLGTL RDHQSSPYAA VPYKLFTDHG GLNEKRKQRR IRTTFTSAQL KELERVFAET 
HYPDIYTREE LALKIDLTEA RVQVWFQNRR AKFRKQERAA AAAAAAAKNG SSGKKSDSSR 
DDESKEAKST DPDSTGGPGP NPNPTPSCGA NGGGGGGPSP AGAPGAAGPG GPGGEPGKGG 
AAAAAAAAAA AAAAAAAAAA GGLAAAGGPG QGWAPGPGPI TSIPDSLGGP FASVLSSLQR 
PNGAKAALVK SSMF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.