Genular: Defining Cellular Identity and Function

Details for: Pnp

Gene ID: 18950

Symbol: Pnp

Ensembl ID: ENSMUSG00000115338

Description: purine-nucleoside phosphorylase

Associated with

Drug adme
(R-MMU-9748784)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Metabolism of nucleotides
(R-MMU-15869)
Neutrophil degranulation
(R-MMU-6798695)
Nucleotide catabolism
(R-MMU-8956319)
Nucleotide salvage
(R-MMU-8956321)
Purine catabolism
(R-MMU-74259)
Purine salvage
(R-MMU-74217)
Ribavirin adme
(R-MMU-9755088)
Adenosine catabolic process
(GO:0006154)
Allantoin metabolic process
(GO:0000255)
Alpha-beta t cell differentiation
(GO:0046632)
Amide catabolic process
(GO:0043605)
Amp catabolic process
(GO:0006196)
Amp salvage
(GO:0044209)
Apoptotic mitochondrial changes
(GO:0008637)
B cell differentiation
(GO:0030183)
Catalytic activity
(GO:0003824)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Damp catabolic process
(GO:0046059)
Deoxyadenosine catabolic process
(GO:0006157)
Deoxyguanosine catabolic process
(GO:0006161)
Deoxyinosine catabolic process
(GO:0006149)
Dgmp catabolic process
(GO:0046055)
Dgtp metabolic process
(GO:0046070)
Dna repair
(GO:0006281)
Extracellular region
(GO:0005576)
Glycosyltransferase activity
(GO:0016757)
Gmp catabolic process
(GO:0046038)
Gmp catabolic process to guanine
(GO:0006202)
Gmp salvage
(GO:0032263)
Gtp biosynthetic process
(GO:0006183)
Guanosine catabolic process
(GO:0046115)
Guanosine phosphorylase activity
(GO:0047975)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Imp catabolic process
(GO:0006204)
Imp salvage
(GO:0032264)
Inosine catabolic process
(GO:0006148)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Negative regulation of t cell apoptotic process
(GO:0070233)
Nicotinamide riboside catabolic process
(GO:0006738)
Nucleobase-containing compound metabolic process
(GO:0006139)
Nucleoside binding
(GO:0001882)
Nucleoside metabolic process
(GO:0009116)
Nucleotide biosynthetic process
(GO:0009165)
Pentosyltransferase activity
(GO:0016763)
Phosphate ion binding
(GO:0042301)
Positive regulation of alpha-beta t cell differentiation
(GO:0046638)
Positive regulation of b cell differentiation
(GO:0045579)
Positive regulation of dna repair
(GO:0045739)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Positive regulation of t cell proliferation
(GO:0042102)
Purine-containing compound salvage
(GO:0043101)
Purine-nucleoside phosphorylase activity
(GO:0004731)
Purine nucleobase binding
(GO:0002060)
Purine nucleoside metabolic process
(GO:0042278)
Purine ribonucleoside salvage
(GO:0006166)
Response to gamma radiation
(GO:0010332)
Response to xenobiotic stimulus
(GO:0009410)
T cell apoptotic process
(GO:0070231)
T cell proliferation
(GO:0042098)
Transferase activity
(GO:0016740)
Urate biosynthetic process
(GO:0034418)

Other Information

Proteins

Purine nucleoside phosphorylase
Q543K9_MOUSE

Genular Protein ID: 3754323106

Symbol: PNPH_MOUSE

Name: Purine nucleoside phosphorylase

UniProtKB Accession Codes:

P23492 Q4FJT6

Database IDs:

Citations:

PubMed ID: 1902950

Title: Nucleotide sequence of murine purine nucleoside phosphorylase cDNA.

PubMed ID: 1902950

DOI: 10.1093/nar/19.7.1708

PubMed ID: 1374046

Title: Isolation and expression of a murine purine nucleoside phosphorylase-encoding cDNA and sequence similarity with the human message.

PubMed ID: 1374046

DOI: 10.1016/0378-1119(92)90398-9

PubMed ID: 7903568

Title: cDNA sequence of four purine nucleoside phosphorylase (Np) alleles in the mouse.

PubMed ID: 7903568

DOI: 10.1007/bf00361392

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10859343

Title: Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice.

PubMed ID: 10859343

DOI: 10.1084/jem.191.12.2197

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22521465

Title: Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice.

PubMed ID: 22521465

DOI: 10.1016/j.nbd.2012.04.001

Sequence Information:

Length: 289
Mass: 32277
Checksum: DE7C1C2B004A1113
Sequence:

MENEFTYEDY ETTAKWLLQH TEYRPQVAVI CGSGLGGLTA HLKEAQIFDY NEIPNFPQST 
VQGHAGRLVF GLLNGRCCVM MQGRFHMYEG YSLSKVTFPV RVFHLLGVET LVVTNAAGGL 
NPNFEVGDIM LIRDHINLPG FCGQNPLRGP NDERFGVRFP AMSDAYDRDM RQKAFTAWKQ 
MGEQRKLQEG TYVMLAGPNF ETVAESRLLK MLGADAVGMS TVPEVIVARH CGLRVFGFSL 
ITNKVVMDYE NLEKANHMEV LDAGKAAAQT LERFVSILME SIPLPDRGS

Genular Protein ID: 2124562029

Symbol: Q543K9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q543K9

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 289
Mass: 32263
Checksum: AE7E497B004A1116
Sequence:

MENEFTYEDY ETTAKWLLQH TEYRPQVAVI CGSGLGGLTA HLKEAQIFDY NEIPNFPQST 
VQGHAGRLVF GLLNGRCCVM MQGRFHMYEG YSLSKVTFPV RVFHLLGVET LVVTNAAGGL 
NPNFEVGDIM LIRDHINLPG FCGQNPLRGP NDERFGVRFP AMSDAYDRDM RQKAFSAWKQ 
MGEQRKLQEG TYVMLAGPNF ETVAESRLLK MLGADAVGMS TVPEVIVARH CGLRVFGFSL 
ITNKVVMDYE NLEKANHMEV LDAGKAAAQT LERFVSILME SIPLPDRGS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pnp

Associated with

Other Information

Nucleotide sequence of murine purine nucleoside phosphorylase cDNA. PubMed ID: 1902950

Isolation and expression of a murine purine nucleoside phosphorylase-encoding cDNA and sequence similarity with the human message. PubMed ID: 1374046

cDNA sequence of four purine nucleoside phosphorylase (Np) alleles in the mouse. PubMed ID: 7903568

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice. PubMed ID: 10859343

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice. PubMed ID: 22521465

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 1902950

PubMed ID: 1374046

PubMed ID: 7903568

PubMed ID: 15489334

PubMed ID: 10859343

PubMed ID: 21183079

PubMed ID: 22521465

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 19468303

PubMed ID: 21183079