Genular: Defining Cellular Identity and Function

Details for: Pomc

Gene ID: 18976

Symbol: Pomc

Ensembl ID: ENSMUSG00000020660

Description: pro-opiomelanocortin-alpha

Associated with

Androgen biosynthesis
(R-MMU-193048)
Biological oxidations
(R-MMU-211859)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
Cytochrome p450 - arranged by substrate type
(R-MMU-211897)
Endogenous sterols
(R-MMU-211976)
G-protein activation
(R-MMU-202040)
G alpha (i) signalling events
(R-MMU-418594)
G alpha (s) signalling events
(R-MMU-418555)
Glucocorticoid biosynthesis
(R-MMU-194002)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of proteins
(R-MMU-392499)
Metabolism of steroid hormones
(R-MMU-196071)
Metabolism of steroids
(R-MMU-8957322)
Opioid signalling
(R-MMU-111885)
Peptide hormone biosynthesis
(R-MMU-209952)
Peptide hormone metabolism
(R-MMU-2980736)
Peptide ligand-binding receptors
(R-MMU-375276)
Phase i - functionalization of compounds
(R-MMU-211945)
Signaling by gpcr
(R-MMU-372790)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Calcium-mediated signaling
(GO:0019722)
Cell-cell signaling
(GO:0007267)
Cellular pigmentation
(GO:0033059)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Generation of precursor metabolites and energy
(GO:0006091)
Glucose homeostasis
(GO:0042593)
G protein-coupled receptor binding
(GO:0001664)
Hormone activity
(GO:0005179)
Killing of cells of another organism
(GO:0031640)
Modulation of process of another organism
(GO:0035821)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Neuropeptide signaling pathway
(GO:0007218)
Peroxisomal matrix
(GO:0005782)
Positive regulation of camp-mediated signaling
(GO:0043950)
Positive regulation of neutrophil mediated killing of fungus
(GO:0070965)
Positive regulation of oxytocin production
(GO:0140668)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of appetite
(GO:0032098)
Regulation of blood pressure
(GO:0008217)
Regulation of corticosterone secretion
(GO:2000852)
Regulation of glycogen metabolic process
(GO:0070873)
Response to melanocyte-stimulating hormone
(GO:1990680)
Secretory granule
(GO:0030141)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Type 1 melanocortin receptor binding
(GO:0070996)
Type 3 melanocortin receptor binding
(GO:0031781)
Type 4 melanocortin receptor binding
(GO:0031782)

Other Information

Proteins

Pro-opiomelanocortin

Genular Protein ID: 1103553474

Symbol: COLI_MOUSE

Name: Pro-opiomelanocortin

UniProtKB Accession Codes:

P01193 P01200 Q544U4

Database IDs:

Citations:

PubMed ID: 6303853

Title: Isolation and characterization of the mouse corticotropin-beta-lipotropin precursor gene and a related pseudogene.

PubMed ID: 6303853

DOI: 10.1016/0014-5793(83)80250-6

PubMed ID: 6308009

Title: The mouse genome contains two nonallelic pro-opiomelanocortin genes.

PubMed ID: 6308009

DOI: 10.1016/s0021-9258(17)44688-6

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2536749

Title: Expression of mouse proopiomelanocortin in an insulinoma cell line. Requirements for beta-endorphin processing.

PubMed ID: 2536749

DOI: 10.1016/s0021-9258(18)94100-1

PubMed ID: 1689057

Title: Nucleotide and amino acid sequence of lymphocyte-derived corticotropin: endotoxin induction of a truncated peptide.

PubMed ID: 1689057

DOI: 10.1073/pnas.87.3.1057

PubMed ID: 221916

Title: Corticotropin and beta-endorphin: construction and analysis of recombinant DNA complementary to mRNA for the common precursor.

PubMed ID: 221916

DOI: 10.1073/pnas.76.5.2153

PubMed ID: 25707796

Title: Hypothalamic POMC neurons promote cannabinoid-induced feeding.

PubMed ID: 25707796

DOI: 10.1038/nature14260

Sequence Information:

Length: 235
Mass: 26707
Checksum: EF98C0A95D6B4991
Sequence:

MPRFCYSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC KLDLSLETPV 
FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGSAAQ RRAEEEAVWG DGSPEPSPRE 
GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA ENESAEAFPL EFKRELEGER PLGLEQVLES 
DAEKDDGPYR VEHFRWSNPP KDKRYGGFMT SEKSQTPLVT LFKNAIIKNA HKKGQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pomc

Associated with

Other Information

Isolation and characterization of the mouse corticotropin-beta-lipotropin precursor gene and a related pseudogene. PubMed ID: 6303853

The mouse genome contains two nonallelic pro-opiomelanocortin genes. PubMed ID: 6308009

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of mouse proopiomelanocortin in an insulinoma cell line. Requirements for beta-endorphin processing. PubMed ID: 2536749

Nucleotide and amino acid sequence of lymphocyte-derived corticotropin: endotoxin induction of a truncated peptide. PubMed ID: 1689057

Corticotropin and beta-endorphin: construction and analysis of recombinant DNA complementary to mRNA for the common precursor. PubMed ID: 221916

Hypothalamic POMC neurons promote cannabinoid-induced feeding. PubMed ID: 25707796