Details for: Pou4f2

Gene ID: 18997

Symbol: Pou4f2

Ensembl ID: ENSMUSG00000031688

Description: POU domain, class 4, transcription factor 2

Associated with

  • Gene expression (transcription)
    (R-MMU-74160)
  • Generic transcription pathway
    (R-MMU-212436)
  • Regulation of tp53 activity
    (R-MMU-5633007)
  • Regulation of tp53 activity through association with co-factors
    (R-MMU-6804759)
  • Rna polymerase ii transcription
    (R-MMU-73857)
  • Transcriptional regulation by tp53
    (R-MMU-3700989)
  • Apoptotic process
    (GO:0006915)
  • Axon extension
    (GO:0048675)
  • Axon guidance
    (GO:0007411)
  • Axonogenesis
    (GO:0007409)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to cytokine stimulus
    (GO:0071345)
  • Cellular response to estradiol stimulus
    (GO:0071392)
  • Cellular response to insulin stimulus
    (GO:0032869)
  • Cellular response to oxygen levels
    (GO:0071453)
  • Chromatin binding
    (GO:0003682)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Dorsal root ganglion development
    (GO:1990791)
  • Euchromatin
    (GO:0000791)
  • Heart development
    (GO:0007507)
  • Intracellular estrogen receptor signaling pathway
    (GO:0030520)
  • Intrinsic apoptotic signaling pathway by p53 class mediator
    (GO:0072332)
  • Mapk cascade
    (GO:0000165)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of adipose tissue development
    (GO:1904178)
  • Negative regulation of amacrine cell differentiation
    (GO:1902870)
  • Negative regulation of cell differentiation
    (GO:0045596)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuromuscular process controlling balance
    (GO:0050885)
  • Neuron differentiation
    (GO:0030182)
  • Nuclear speck
    (GO:0016607)
  • Nucleus
    (GO:0005634)
  • P53 binding
    (GO:0002039)
  • Positive regulation of axon extension
    (GO:0045773)
  • Positive regulation of cardiac muscle cell apoptotic process
    (GO:0010666)
  • Positive regulation of cell differentiation
    (GO:0045597)
  • Positive regulation of glucose import
    (GO:0046326)
  • Positive regulation of osteoclast differentiation
    (GO:0045672)
  • Positive regulation of programmed cell death
    (GO:0043068)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transcription regulatory region dna binding
    (GO:2000679)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-binding transcription factor activity
    (GO:0051090)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of retinal ganglion cell axon guidance
    (GO:0090259)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Retina development in camera-type eye
    (GO:0060041)
  • Retinal ganglion cell axon guidance
    (GO:0031290)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sensory perception of sound
    (GO:0007605)
  • Sequence-specific dna binding
    (GO:0043565)
  • Transcription regulator complex
    (GO:0005667)

Other Information

Genular Protein ID: 1718205981

Symbol: PO4F2_MOUSE

Name: Brain-specific homeobox/POU domain protein 3B

UniProtKB Accession Codes:

Q63934 Q63954

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 3 Ensembl 1 GO 51 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7904822

Title: Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid.

PubMed ID: 7904822

DOI: 10.1016/0896-6273(94)90164-3

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 8162704

Title: Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes.

PubMed ID: 8162704

DOI: 10.1159/000133709

PubMed ID: 7691107

Title: Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells.

PubMed ID: 7691107

DOI: 10.1016/0896-6273(93)90079-7

PubMed ID: 8290353

Title: Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a.

PubMed ID: 8290353

DOI: 10.1093/nar/21.25.5921

PubMed ID: 7935408

Title: The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain.

PubMed ID: 7935408

DOI: 10.1128/mcb.14.10.6907-6914.1994

PubMed ID: 8065921

Title: The DNA target site for the Brn-3 POU family transcription factors can confer responsiveness to cyclic AMP and removal of serum in neuronal cells.

PubMed ID: 8065921

DOI: 10.1093/nar/22.15.3092

PubMed ID: 8537352

Title: Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding.

PubMed ID: 8537352

DOI: 10.1074/jbc.270.52.30958

PubMed ID: 8637595

Title: Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development.

PubMed ID: 8637595

DOI: 10.1038/381603a0

PubMed ID: 7852360

Title: Activation of the alpha-internexin promoter by the Brn-3a transcription factor is dependent on the N-terminal region of the protein.

PubMed ID: 7852360

DOI: 10.1074/jbc.270.6.2853

PubMed ID: 7797498

Title: The neuronal nicotinic acetylcholine receptor alpha 2 subunit gene promoter is activated by the Brn-3b POU family transcription factor and not by Brn-3a or Brn-3c.

PubMed ID: 7797498

DOI: 10.1074/jbc.270.25.15143

PubMed ID: 8662774

Title: A single amino acid change converts an inhibitory transcription factor into an activator.

PubMed ID: 8662774

DOI: 10.1074/jbc.271.20.11631

PubMed ID: 8632990

Title: POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells.

PubMed ID: 8632990

DOI: 10.1073/pnas.93.9.3920

PubMed ID: 8995448

Title: Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor.

PubMed ID: 8995448

DOI: 10.1074/jbc.272.2.1382

PubMed ID: 9261145

Title: Coordinate induction of the three neurofilament genes by the Brn-3a transcription factor.

PubMed ID: 9261145

DOI: 10.1074/jbc.272.34.21325

PubMed ID: 8972215

Title: The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins.

PubMed ID: 8972215

DOI: 10.1128/mcb.17.1.345

PubMed ID: 9111308

Title: POU domain factors of the Brn-3 class recognize functional DNA elements which are distinctive, symmetrical, and highly conserved in evolution.

PubMed ID: 9111308

DOI: 10.1128/mcb.17.5.2391

PubMed ID: 9448000

Title: POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.

PubMed ID: 9448000

DOI: 10.1128/mcb.18.2.1029

PubMed ID: 9694219

Title: Functional role of position 22 in the homeodomain of Brn-3 transcription factors.

PubMed ID: 9694219

DOI: 10.1097/00001756-199807130-00029

PubMed ID: 10357904

Title: POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification.

PubMed ID: 10357904

DOI: 10.1006/dbio.1999.9280

PubMed ID: 10526314

Title: Evidence that POU factor Brn-3B regulates expression of Pax-6 in neuroretina cells.

PubMed ID: 10526314

DOI: 10.1002/(sici)1097-4695(19991115)41:3<349::aid-neu4>3.0.co;2-f

PubMed ID: 10414983

Title: Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 locus.

PubMed ID: 10414983

DOI: 10.1523/jneurosci.19-15-06549.1999

PubMed ID: 11163266

Title: A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system.

PubMed ID: 11163266

DOI: 10.1016/s0896-6273(00)00153-7

PubMed ID: 14726699

Title: Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor.

PubMed ID: 14726699

DOI: 10.4161/cbt.3.3.698

PubMed ID: 15733064

Title: Identification of an N-terminal transcriptional activation domain within Brn3b/POU4f2.

PubMed ID: 15733064

DOI: 10.1111/j.1432-0436.2005.07301004.x

PubMed ID: 16152597

Title: The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells.

PubMed ID: 16152597

DOI: 10.1002/ijc.21435

PubMed ID: 17145718

Title: Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.

PubMed ID: 17145718

DOI: 10.1093/nar/gkl878

PubMed ID: 17668438

Title: Brn3 transcription factors control terminal osteoclastogenesis.

PubMed ID: 17668438

DOI: 10.1002/jcb.21257

PubMed ID: 18368538

Title: Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression.

PubMed ID: 18368538

DOI: 10.1007/s12192-008-0028-2

PubMed ID: 21875655

Title: Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina.

PubMed ID: 21875655

DOI: 10.1016/j.neuroscience.2011.08.015

PubMed ID: 22326227

Title: Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord.

PubMed ID: 22326227

DOI: 10.1016/j.ydbio.2012.01.021

PubMed ID: 23805044

Title: RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors.

PubMed ID: 23805044

PubMed ID: 24643061

Title: Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells.

PubMed ID: 24643061

DOI: 10.1371/journal.pone.0092105

PubMed ID: 25775587

Title: Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate.

PubMed ID: 25775587

DOI: 10.1073/pnas.1421535112

Sequence Information:

  • Length: 411
  • Mass: 43173
  • Checksum: 97EA816F7DEC07C9
  • Sequence:
    • MMMMSLNSKQ AFSMPHAGSL HVEPKYSALH SASPGSSAPA APSASSPSSS SNAGGGGGGG 
GGGGGGGRSS SSSSSGSGGS GGGGGSEAMR RACLPTPPSN IFGGLDESLL ARAEALAAVD 
IVSQSKSHHH HPPHHSPFKP DATYHTMNTI PCTSAASSSS VPISHPSALA GTHHHHHHHH 
HHHHQPHQAL EGELLEHLSP GLALGAMAGP DGTVVSTPAH APHMATMNPM HQAALSMAHA 
HGLPSHMGCM SDVDADPRDL EAFAERFKQR RIKLGVTQAD VGSALANLKI PGVGSLSQST 
ICRFESLTLS HNNMIALKPI LQAWLEEAEK SHREKLTKPE LFNGAEKKRK RTSIAAPEKR 
SLEAYFAIQP RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRMKYSAG I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.