Genular: Defining Cellular Identity and Function

Details for: Pou5f1

Gene ID: 18999

Symbol: Pou5f1

Ensembl ID: ENSMUSG00000024406

Description: POU domain, class 5, transcription factor 1

Associated with

Blastocyst development
(GO:0001824)
Blastocyst growth
(GO:0001832)
Cell fate commitment
(GO:0045165)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytokine binding
(GO:0019955)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Ectodermal cell fate commitment
(GO:0001712)
Endodermal cell fate commitment
(GO:0001711)
Endodermal cell fate specification
(GO:0001714)
Female germ cell nucleus
(GO:0001674)
Gene expression
(GO:0010467)
Germ-line stem cell population maintenance
(GO:0030718)
Germ cell nucleus
(GO:0043073)
Hmg box domain binding
(GO:0071837)
Lysine-acetylated histone binding
(GO:0070577)
Male germ cell nucleus
(GO:0001673)
Mesodermal cell fate commitment
(GO:0001710)
Mirna binding
(GO:0035198)
Mitochondrion
(GO:0005739)
Multicellular organism development
(GO:0007275)
Negative regulation of calcium ion-dependent exocytosis
(GO:0045955)
Negative regulation of cell differentiation
(GO:0045596)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Pou domain binding
(GO:0070974)
Protein binding
(GO:0005515)
Regulation of asymmetric cell division
(GO:0009786)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to organic substance
(GO:0010033)
Response to retinoic acid
(GO:0032526)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii intronic transcription regulatory region sequence-specific dna binding
(GO:0001162)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Somatic stem cell population maintenance
(GO:0035019)
Stem cell differentiation
(GO:0048863)
Stem cell population maintenance
(GO:0019827)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription regulator complex
(GO:0005667)
Transcription repressor complex
(GO:0017053)
Trophectodermal cell differentiation
(GO:0001829)
Trophectodermal cell fate commitment
(GO:0001830)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

POU domain, class 5, transcription factor 1
A0A2I6EDI9_MOUSE

Genular Protein ID: 1467659175

Symbol: PO5F1_MOUSE

Name: POU domain, class 5, transcription factor 1

UniProtKB Accession Codes:

P20263 Q63843

Database IDs:

Citations:

PubMed ID: 1972777

Title: A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.

PubMed ID: 1972777

DOI: 10.1038/345686a0

PubMed ID: 1690859

Title: New type of POU domain in germ line-specific protein Oct-4.

PubMed ID: 1690859

DOI: 10.1038/344435a0

PubMed ID: 1967980

Title: A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells.

PubMed ID: 1967980

DOI: 10.1016/0092-8674(90)90597-8

PubMed ID: 1915274

Title: The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer.

PubMed ID: 1915274

DOI: 10.1002/j.1460-2075.1991.tb07850.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15863505

Title: Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells.

PubMed ID: 15863505

DOI: 10.1074/jbc.m501423200

PubMed ID: 17097055

Title: Inhibition of DNA binding of Sox2 by the SUMO conjugation.

PubMed ID: 17097055

DOI: 10.1016/j.bbrc.2006.10.130

PubMed ID: 16904174

Title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

PubMed ID: 16904174

DOI: 10.1016/j.cell.2006.07.024

PubMed ID: 17496161

Title: Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1.

PubMed ID: 17496161

DOI: 10.1096/fj.06-6914com

PubMed ID: 17525163

Title: Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation.

PubMed ID: 17525163

DOI: 10.1074/jbc.m611041200

PubMed ID: 18662995

Title: Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression.

PubMed ID: 18662995

DOI: 10.1128/mcb.00301-08

PubMed ID: 19740739

Title: Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells.

PubMed ID: 19740739

DOI: 10.1074/jbc.m109.016162

PubMed ID: 19997087

Title: Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner.

PubMed ID: 19997087

DOI: 10.1038/cr.2009.136

PubMed ID: 24550733

Title: Zfp322a Regulates mouse ES cell pluripotency and enhances reprogramming efficiency.

PubMed ID: 24550733

DOI: 10.1371/journal.pgen.1004038

PubMed ID: 29153991

Title: Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells.

PubMed ID: 29153991

DOI: 10.1016/j.stemcr.2017.10.017

PubMed ID: 32703285

Title: Ddx56 maintains proliferation of mouse embryonic stem cells via ribosome assembly and interaction with the Oct4/Sox2 complex.

PubMed ID: 32703285

DOI: 10.1186/s13287-020-01800-w

PubMed ID: 8097478

Title: Secondary structure of the oct-3 POU homeodomain as determined by 1H-15N NMR spectroscopy.

PubMed ID: 8097478

DOI: 10.1016/0014-5793(93)80088-c

PubMed ID: 23376973

Title: A unique Oct4 interface is crucial for reprogramming to pluripotency.

PubMed ID: 23376973

DOI: 10.1038/ncb2680

Sequence Information:

Length: 352
Mass: 38216
Checksum: 757E41DF52286714
Sequence:

MAGHLASDFA FSPPPGGGDG SAGLEPGWVD PRTWLSFQGP PGGPGIGPGS EVLGISPCPP 
AYEFCGGMAY CGPQVGLGLV PQVGVETLQP EGQAGARVES NSEGTSSEPC ADRPNAVKLE 
KVEPTPEESQ DMKALQKELE QFAKLLKQKR ITLGYTQADV GLTLGVLFGK VFSQTTICRF 
EALQLSLKNM CKLRPLLEKW VEEADNNENL QEICKSETLV QARKRKRTSI ENRVRWSLET 
MFLKCPKPSL QQITHIANQL GLEKDVVRVW FCNRRQKGKR SSIEYSQREE YEATGTPFPG 
GAVSFPLPPG PHFGTPGYGS PHFTTLYSVP FPEGEAFPSV PVTALGSPMH SN

Genular Protein ID: 3760645666

Symbol: A0A2I6EDI9_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A2I6EDI9

Database IDs:

Citations:

PubMed ID: 29266259

Title: Characterization of novel alternative splicing variants of Oct4 gene expressed in mouse pluripotent stem cells.

PubMed ID: 29266259

Sequence Information:

Length: 221
Mass: 25016
Checksum: F447F6898F0AE984
Sequence:

MKALQKELEQ FAKLLKQKRI TLGYTQADVG LTLGVLFGKV FSQTTICRFE ALQLSLKNMC 
KLRPLLEKWV EEADNNENLQ EICKSETLVQ ARKRKRTSIE NRVRWSLETM FLKCPKPSLQ 
QITHIANQLG LEKDVVRVWF CNRRQKGKRS SIEYSQREEY EATGTPFPGG AVSFPLPPGP 
HFGTPGYGSP HFTTLYSVPF PEGEAFPSVP VTALGSPMHS N

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pou5f1

Associated with

Other Information

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. PubMed ID: 1972777

New type of POU domain in germ line-specific protein Oct-4. PubMed ID: 1690859

A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. PubMed ID: 1967980

The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer. PubMed ID: 1915274

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. PubMed ID: 15863505

Inhibition of DNA binding of Sox2 by the SUMO conjugation. PubMed ID: 17097055

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. PubMed ID: 16904174

Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1. PubMed ID: 17496161

Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. PubMed ID: 17525163

Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. PubMed ID: 18662995

Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. PubMed ID: 19740739

Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner. PubMed ID: 19997087

Zfp322a Regulates mouse ES cell pluripotency and enhances reprogramming efficiency. PubMed ID: 24550733

Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells. PubMed ID: 29153991

Ddx56 maintains proliferation of mouse embryonic stem cells via ribosome assembly and interaction with the Oct4/Sox2 complex. PubMed ID: 32703285

Secondary structure of the oct-3 POU homeodomain as determined by 1H-15N NMR spectroscopy. PubMed ID: 8097478

A unique Oct4 interface is crucial for reprogramming to pluripotency. PubMed ID: 23376973

Characterization of novel alternative splicing variants of Oct4 gene expressed in mouse pluripotent stem cells. PubMed ID: 29266259