Details for: ABCA1

Gene ID: 19

Symbol: ABCA1

Ensembl ID: ENSG00000165029

Description: ATP binding cassette subfamily A member 1

Associated with

Cells (max top 100)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.86
    Marker Score: 50747
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.61
    Marker Score: 3007
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.61
    Marker Score: 8559
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.54
    Marker Score: 929
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.33
    Marker Score: 49677
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.21
    Marker Score: 1230
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.11
    Marker Score: 2114
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.04
    Marker Score: 1138.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.97
    Marker Score: 10613
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.85
    Marker Score: 1220
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.75
    Marker Score: 11266
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.74
    Marker Score: 1504
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.73
    Marker Score: 589
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.72
    Marker Score: 7422
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.67
    Marker Score: 384
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.56
    Marker Score: 3004
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.55
    Marker Score: 1863
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.53
    Marker Score: 3599
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.51
    Marker Score: 6273
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167882
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.46
    Marker Score: 833
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.38
    Marker Score: 22207
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.36
    Marker Score: 1538
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.36
    Marker Score: 437
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.36
    Marker Score: 1690
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.35
    Marker Score: 49725.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.33
    Marker Score: 45209.5
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.32
    Marker Score: 29594.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3
    Marker Score: 20315
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.29
    Marker Score: 486
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.29
    Marker Score: 708
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.28
    Marker Score: 766
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.27
    Marker Score: 956
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.18
    Marker Score: 779
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.18
    Marker Score: 1811
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.17
    Marker Score: 794
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.13
    Marker Score: 1208
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.13
    Marker Score: 547.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.11
    Marker Score: 759
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.1
    Marker Score: 457
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.09
    Marker Score: 270
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.09
    Marker Score: 4202
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.07
    Marker Score: 530.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.07
    Marker Score: 277
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.06
    Marker Score: 2771
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.05
    Marker Score: 330
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.04
    Marker Score: 11766.5
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251704
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.01
    Marker Score: 7764
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1
    Marker Score: 1109.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1
    Marker Score: 6034
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1
    Marker Score: 10351
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71724
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47950.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.98
    Marker Score: 1441
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.97
    Marker Score: 1202
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.96
    Marker Score: 578
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.95
    Marker Score: 1057
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.92
    Marker Score: 262
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.92
    Marker Score: 242
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.91
    Marker Score: 1129
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2713
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.9
    Marker Score: 230
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.9
    Marker Score: 449
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.89
    Marker Score: 1075
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.88
    Marker Score: 936
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.88
    Marker Score: 5353
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.88
    Marker Score: 33361
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.87
    Marker Score: 13036
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.86
    Marker Score: 322
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.86
    Marker Score: 1039
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.86
    Marker Score: 193
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.86
    Marker Score: 465
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.86
    Marker Score: 1032.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4875
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.85
    Marker Score: 754
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.85
    Marker Score: 2126
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.83
    Marker Score: 983
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.83
    Marker Score: 168
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.83
    Marker Score: 5374
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.82
    Marker Score: 938
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.82
    Marker Score: 808.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.81
    Marker Score: 362
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 615
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.8
    Marker Score: 661
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.8
    Marker Score: 1404
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.79
    Marker Score: 377
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.79
    Marker Score: 273
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.78
    Marker Score: 421
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.77
    Marker Score: 994
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.77
    Marker Score: 446
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.77
    Marker Score: 15287
## Summary ABCA1 is a protein that is involved in the assembly and trafficking of proteins involved in cholesterol transport and efflux. It is expressed in a variety of cell types, including endothelial cells, hepatocytes, and fibroblasts. ## Key characteristics * ABCA1 is a transmembrane protein that is expressed in the plasma membrane of cells. * It is a member of the ATP-binding cassette subfamily A (ABC) of proteins. * It is a key regulator of cholesterol transport and efflux in cells. * It is involved in the assembly and trafficking of proteins involved in cholesterol transport and efflux. * It is also involved in the regulation of lipid metabolism. ## Pathways and functions * ABCA1 is involved in the assembly and trafficking of proteins involved in cholesterol transport and efflux. * It is responsible for the sorting and transport of proteins to the cell surface. * It is also involved in the regulation of cholesterol efflux from cells. * It is involved in the metabolism of lipids. * It is also involved in the regulation of inflammation. ## Clinical significance ABCA1 is a gene that is linked to a number of human diseases. Mutations in ABCA1 have been linked to a number of diseases, including familial hypercholesterolemia, atherosclerosis, and diabetes. These diseases are characterized by high levels of cholesterol in the blood. ABCA1 is a potential target for the treatment of these diseases. By blocking ABCA1, it is possible to lower cholesterol levels and reduce the risk of developing these diseases.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.