ABCA1 - ENSG00000165029

Details for: ABCA1

Gene ID: 19

Symbol: ABCA1

Ensembl ID: ENSG00000165029

Description: ATP binding cassette subfamily A member 1

Associated with

Abc transporter disorders (R-HSA-5619084)
Defective abca1 causes tgd (R-HSA-5682113)
Disease (R-HSA-1643685)
Disorders of transmembrane transporters (R-HSA-5619115)
Hdl assembly (R-HSA-8963896)
Metabolism (R-HSA-1430728)
Metabolism of lipids (R-HSA-556833)
Nr1h2 and nr1h3-mediated signaling (R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux (R-HSA-9029569)
Plasma lipoprotein assembly (R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance (R-HSA-174824)
Ppara activates gene expression (R-HSA-1989781)
Regulation of lipid metabolism by pparalpha (R-HSA-400206)
Signaling by nuclear receptors (R-HSA-9006931)
Signal transduction (R-HSA-162582)
Transport of small molecules (R-HSA-382551)
Abc-type transporter activity (GO:0140359)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway (GO:0007189)
Apolipoprotein a-i-mediated signaling pathway (GO:0038027)
Apolipoprotein a-i binding (GO:0034186)
Apolipoprotein a-i receptor activity (GO:0034188)
Apolipoprotein binding (GO:0034185)
Atpase-coupled transmembrane transporter activity (GO:0042626)
Atpase binding (GO:0051117)
Atp binding (GO:0005524)
Atp hydrolysis activity (GO:0016887)
Basolateral plasma membrane (GO:0016323)
Cellular response to cholesterol (GO:0071397)
Cellular response to cytokine stimulus (GO:0071345)
Cellular response to lipopolysaccharide (GO:0071222)
Cellular response to low-density lipoprotein particle stimulus (GO:0071404)
Cellular response to retinoic acid (GO:0071300)
Cellular response to xenobiotic stimulus (GO:0071466)
Cholesterol binding (GO:0015485)
Cholesterol efflux (GO:0033344)
Cholesterol homeostasis (GO:0042632)
Cholesterol metabolic process (GO:0008203)
Cholesterol transfer activity (GO:0120020)
Endocytic vesicle (GO:0030139)
Endoplasmic reticulum membrane (GO:0005789)
Endosomal transport (GO:0016197)
Endosome (GO:0005768)
Export across plasma membrane (GO:0140115)
External side of plasma membrane (GO:0009897)
Floppase activity (GO:0140328)
Golgi apparatus (GO:0005794)
G protein-coupled receptor signaling pathway (GO:0007186)
High-density lipoprotein particle assembly (GO:0034380)
High-density lipoprotein particle binding (GO:0008035)
Intermembrane lipid transfer (GO:0120009)
Intracellular cholesterol transport (GO:0032367)
Intracellular membrane-bounded organelle (GO:0043231)
Lipoprotein biosynthetic process (GO:0042158)
Lysosome organization (GO:0007040)
Membrane raft (GO:0045121)
Negative regulation of cholesterol storage (GO:0010887)
Negative regulation of macrophage derived foam cell differentiation (GO:0010745)
Peptide secretion (GO:0002790)
Perinuclear region of cytoplasm (GO:0048471)
Phagocytic vesicle (GO:0045335)
Phagocytosis, engulfment (GO:0006911)
Phosphatidylcholine binding (GO:0031210)
Phosphatidylcholine floppase activity (GO:0090554)
Phosphatidylserine floppase activity (GO:0090556)
Phospholipid efflux (GO:0033700)
Phospholipid homeostasis (GO:0055091)
Phospholipid translocation (GO:0045332)
Phospholipid transporter activity (GO:0005548)
Plasma membrane (GO:0005886)
Platelet dense granule organization (GO:0060155)
Positive regulation of cholesterol efflux (GO:0010875)
Positive regulation of high-density lipoprotein particle assembly (GO:0090108)
Protein binding (GO:0005515)
Protein secretion (GO:0009306)
Protein transmembrane transport (GO:0071806)
Protein transmembrane transporter activity (GO:0008320)
Regulation of cdc42 protein signal transduction (GO:0032489)
Regulation of high-density lipoprotein particle assembly (GO:0090107)
Response to laminar fluid shear stress (GO:0034616)
Response to vitamin b3 (GO:0033552)
Reverse cholesterol transport (GO:0043691)
Signaling receptor binding (GO:0005102)
Signal release (GO:0023061)
Small gtpase binding (GO:0031267)
Sphingolipid floppase activity (GO:0046623)
Sphingolipid translocation (GO:0099039)
Syntaxin binding (GO:0019905)

Cells (max top 100)

Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.86
Marker Score: 50747
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.61
Marker Score: 3007
Cell Name: hepatoblast (CL0005026)
Fold Change: 2.61
Marker Score: 8559
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 2.54
Marker Score: 929
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.33
Marker Score: 49677
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.21
Marker Score: 1230
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.11
Marker Score: 2114
Cell Name: fat cell (CL0000136)
Fold Change: 2.04
Marker Score: 1138.5
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.97
Marker Score: 10613
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.85
Marker Score: 1220
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.75
Marker Score: 11266
Cell Name: astrocyte (CL0000127)
Fold Change: 1.74
Marker Score: 1504
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.73
Marker Score: 589
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.72
Marker Score: 7422
Cell Name: keratocyte (CL0002363)
Fold Change: 1.67
Marker Score: 384
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.56
Marker Score: 3004
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.55
Marker Score: 1863
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.53
Marker Score: 3599
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.51
Marker Score: 6273
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167882
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.46
Marker Score: 833
Cell Name: lactocyte (CL0002325)
Fold Change: 1.38
Marker Score: 22207
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.36
Marker Score: 1538
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.36
Marker Score: 437
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.36
Marker Score: 1690
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.35
Marker Score: 49725.5
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.33
Marker Score: 45209.5
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.32
Marker Score: 29594.5
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.3
Marker Score: 20315
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.29
Marker Score: 486
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.29
Marker Score: 708
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.28
Marker Score: 766
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.27
Marker Score: 956
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.18
Marker Score: 779
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.18
Marker Score: 1811
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.17
Marker Score: 794
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.13
Marker Score: 1208
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.13
Marker Score: 547.5
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.11
Marker Score: 759
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.1
Marker Score: 457
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.09
Marker Score: 270
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.09
Marker Score: 4202
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.07
Marker Score: 530.5
Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.07
Marker Score: 277
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.06
Marker Score: 2771
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.05
Marker Score: 330
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.04
Marker Score: 11766.5
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251704
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.01
Marker Score: 7764
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1
Marker Score: 1109.5
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1
Marker Score: 6034
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1
Marker Score: 10351
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71724
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47950.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30397
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.98
Marker Score: 1441
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.97
Marker Score: 1202
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.96
Marker Score: 578
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 490
Cell Name: macrophage (CL0000235)
Fold Change: 0.95
Marker Score: 1057
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2402
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 445
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.92
Marker Score: 262
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.92
Marker Score: 242
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.91
Marker Score: 1129
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2713
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.9
Marker Score: 230
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.9
Marker Score: 449
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.89
Marker Score: 1075
Cell Name: Unknown (CL0002371)
Fold Change: 0.88
Marker Score: 936
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.88
Marker Score: 5353
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.88
Marker Score: 33361
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 315
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.87
Marker Score: 13036
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.86
Marker Score: 322
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.86
Marker Score: 1039
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.86
Marker Score: 193
Cell Name: contractile cell (CL0000183)
Fold Change: 0.86
Marker Score: 465
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.86
Marker Score: 1032.5
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.85
Marker Score: 4875
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.85
Marker Score: 754
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.85
Marker Score: 2126
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.83
Marker Score: 983
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.83
Marker Score: 168
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.83
Marker Score: 5374
Cell Name: lung macrophage (CL1001603)
Fold Change: 0.82
Marker Score: 938
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.82
Marker Score: 800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.82
Marker Score: 808.5
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.81
Marker Score: 325
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.81
Marker Score: 362
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.81
Marker Score: 615
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.8
Marker Score: 661
Cell Name: germ cell (CL0000586)
Fold Change: 0.8
Marker Score: 1404
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.79
Marker Score: 377
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.79
Marker Score: 273
Cell Name: osteoblast (CL0000062)
Fold Change: 0.78
Marker Score: 421
Cell Name: basal cell (CL0000646)
Fold Change: 0.77
Marker Score: 994
Cell Name: mast cell (CL0000097)
Fold Change: 0.77
Marker Score: 446
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.77
Marker Score: 15287

## Summary ABCA1 is a protein that is involved in the assembly and trafficking of proteins involved in cholesterol transport and efflux. It is expressed in a variety of cell types, including endothelial cells, hepatocytes, and fibroblasts. ## Key characteristics * ABCA1 is a transmembrane protein that is expressed in the plasma membrane of cells. * It is a member of the ATP-binding cassette subfamily A (ABC) of proteins. * It is a key regulator of cholesterol transport and efflux in cells. * It is involved in the assembly and trafficking of proteins involved in cholesterol transport and efflux. * It is also involved in the regulation of lipid metabolism. ## Pathways and functions * ABCA1 is involved in the assembly and trafficking of proteins involved in cholesterol transport and efflux. * It is responsible for the sorting and transport of proteins to the cell surface. * It is also involved in the regulation of cholesterol efflux from cells. * It is involved in the metabolism of lipids. * It is also involved in the regulation of inflammation. ## Clinical significance ABCA1 is a gene that is linked to a number of human diseases. Mutations in ABCA1 have been linked to a number of diseases, including familial hypercholesterolemia, atherosclerosis, and diabetes. These diseases are characterized by high levels of cholesterol in the blood. ABCA1 is a potential target for the treatment of these diseases. By blocking ABCA1, it is possible to lower cholesterol levels and reduce the risk of developing these diseases.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.