Ppara | ENSMUSG00000022383 | NCBI 19013

Details for: Ppara

Gene ID: 19013

Symbol: Ppara

Ensembl ID: ENSMUSG00000022383

Description: peroxisome proliferator activated receptor alpha

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Cytoprotection by hmox1
(R-MMU-9707564)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of proteins
(R-MMU-392499)
Nuclear receptor transcription pathway
(R-MMU-383280)
Post-translational protein modification
(R-MMU-597592)
Regulation of lipid metabolism by pparalpha
(R-MMU-400206)
Rna polymerase ii transcription
(R-MMU-73857)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of intracellular receptors
(R-MMU-4090294)
Behavioral response to nicotine
(GO:0035095)
Cell differentiation
(GO:0030154)
Cellular response to starvation
(GO:0009267)
Circadian regulation of gene expression
(GO:0032922)
Dna-binding transcription activator activity
(GO:0001216)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Enamel mineralization
(GO:0070166)
Epidermis development
(GO:0008544)
Fatty acid metabolic process
(GO:0006631)
Gluconeogenesis
(GO:0006094)
Glucose metabolic process
(GO:0006006)
Hormone-mediated signaling pathway
(GO:0009755)
Lipid binding
(GO:0008289)
Lipid metabolic process
(GO:0006629)
Lipoprotein metabolic process
(GO:0042157)
Mdm2/mdm4 family protein binding
(GO:0097371)
Metal ion binding
(GO:0046872)
Mitogen-activated protein kinase kinase kinase binding
(GO:0031435)
Negative regulation of appetite
(GO:0032099)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of cell growth involved in cardiac muscle cell development
(GO:0061052)
Negative regulation of cholesterol storage
(GO:0010887)
Negative regulation of cytokine production involved in inflammatory response
(GO:1900016)
Negative regulation of glycolytic process
(GO:0045820)
Negative regulation of hepatocyte apoptotic process
(GO:1903944)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of leukocyte cell-cell adhesion
(GO:1903038)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Negative regulation of mirna transcription
(GO:1902894)
Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051898)
Negative regulation of reactive oxygen species biosynthetic process
(GO:1903427)
Negative regulation of sequestering of triglyceride
(GO:0010891)
Negative regulation of signaling receptor activity
(GO:2000272)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Nfat protein binding
(GO:0051525)
Nuclear receptor activity
(GO:0004879)
Nuclear steroid receptor activity
(GO:0003707)
Phosphatase binding
(GO:0019902)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fatty acid metabolic process
(GO:0045923)
Positive regulation of fatty acid oxidation
(GO:0046321)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of lipid biosynthetic process
(GO:0046889)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transformation of host cell by virus
(GO:1904189)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of cellular ketone metabolic process
(GO:0010565)
Regulation of circadian rhythm
(GO:0042752)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of fatty acid metabolic process
(GO:0019217)
Regulation of gene expression
(GO:0010468)
Response to hypoxia
(GO:0001666)
Response to insulin
(GO:0032868)
Rhythmic process
(GO:0048511)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Signaling receptor activity
(GO:0038023)
Transcription coactivator binding
(GO:0001223)
Transcription factor binding
(GO:0008134)
Ubiquitin conjugating enzyme binding
(GO:0031624)
Wound healing
(GO:0042060)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Peroxisome proliferator-activated receptor alpha

Genular Protein ID: 2767555486

Symbol: PPARA_MOUSE

Name: Peroxisome proliferator-activated receptor alpha

UniProtKB Accession Codes:

P23204

Database IDs:

Citations:

PubMed ID: 2129546

Title: Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.

PubMed ID: 2129546

DOI: 10.1038/347645a0

PubMed ID: 8123021

Title: Structure of the mouse peroxisome proliferator activated receptor alpha gene.

PubMed ID: 8123021

DOI: 10.1006/bbrc.1994.1222

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7588749

Title: Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes.

PubMed ID: 7588749

DOI: 10.1111/j.1432-1033.1995.219_1.x

PubMed ID: 9325263

Title: Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor.

PubMed ID: 9325263

DOI: 10.1074/jbc.272.41.25500

PubMed ID: 9627117

Title: Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action.

PubMed ID: 9627117

DOI: 10.1038/sj.onc.1201783

PubMed ID: 10788465

Title: Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR.

PubMed ID: 10788465

DOI: 10.1074/jbc.275.18.13510

PubMed ID: 12955147

Title: Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha.

PubMed ID: 12955147

DOI: 10.1038/nature01921

PubMed ID: 16950137

Title: Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.

PubMed ID: 16950137

DOI: 10.1016/j.cmet.2006.08.005

PubMed ID: 18719582

Title: PRDM16 controls a brown fat/skeletal muscle switch.

PubMed ID: 18719582

DOI: 10.1038/nature07182

PubMed ID: 19646743

Title: Identification of a physiologically relevant endogenous ligand for PPARalpha in liver.

PubMed ID: 19646743

DOI: 10.1016/j.cell.2009.05.036

PubMed ID: 20159955

Title: The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors.

PubMed ID: 20159955

DOI: 10.1101/gad.564110

PubMed ID: 28683290

Title: CRY1/2 selectively repress PPARdelta and limit exercise capacity.

PubMed ID: 28683290

DOI: 10.1016/j.cmet.2017.06.002

Sequence Information:

Length: 468
Mass: 52347
Checksum: 2930A5191C610B6B
Sequence:

MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS IGEESSGSFG FADYQYLGSC 
PGSEGSVITD TLSPASSPSS VSCPVIPAST DESPGSALNI ECRICGDKAS GYHYGVHACE 
GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE 
KAKLKAEILT CEHDLKDSET ADLKSLGKRI HEAYLKNFNM NKVKARVILA GKTSNNPPFV 
IHDMETLCMA EKTLVAKMVA NGVEDKEAEV RFFHCCQCMS VETVTELTEF AKAIPGFANL 
DLNDQVTLLK YGVYEAIFTM LSSLMNKDGM LIAYGNGFIT REFLKNLRKP FCDIMEPKFD 
FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNIGYIEKL QEGIVHVLKL HLQSNHPDDT 
FLFPKLLQKM VDLRQLVTEH AQLVQVIKKT ESDAALHPLL QEIYRDMY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ppara

Associated with

Other Information

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. PubMed ID: 2129546

Structure of the mouse peroxisome proliferator activated receptor alpha gene. PubMed ID: 8123021

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes. PubMed ID: 7588749

Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. PubMed ID: 9325263

Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. PubMed ID: 9627117

Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. PubMed ID: 10788465

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. PubMed ID: 12955147

Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. PubMed ID: 16950137

PRDM16 controls a brown fat/skeletal muscle switch. PubMed ID: 18719582

Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. PubMed ID: 19646743

The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. PubMed ID: 20159955

CRY1/2 selectively repress PPARdelta and limit exercise capacity. PubMed ID: 28683290