Genular: Defining Cellular Identity and Function

Details for: Med1

Gene ID: 19014

Symbol: Med1

Ensembl ID: ENSMUSG00000018160

Description: mediator complex subunit 1

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Cytoprotection by hmox1
(R-MMU-9707564)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent gene expression
(R-MMU-9018519)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Nuclear receptor transcription pathway
(R-MMU-383280)
Regulation of lipid metabolism by pparalpha
(R-MMU-400206)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by nuclear receptors
(R-MMU-9006931)
Signal transduction
(R-MMU-162582)
Androgen biosynthetic process
(GO:0006702)
Angiogenesis
(GO:0001525)
Animal organ morphogenesis
(GO:0009887)
Animal organ regeneration
(GO:0031100)
Brain development
(GO:0007420)
Camera-type eye development
(GO:0043010)
Cell morphogenesis
(GO:0000902)
Cellular response to hepatocyte growth factor stimulus
(GO:0035729)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Embryonic heart tube development
(GO:0035050)
Embryonic hemopoiesis
(GO:0035162)
Embryonic hindlimb morphogenesis
(GO:0035116)
Embryonic placenta development
(GO:0001892)
Erythrocyte development
(GO:0048821)
Fat cell differentiation
(GO:0045444)
G0 to g1 transition
(GO:0045023)
General transcription initiation factor binding
(GO:0140296)
Heart development
(GO:0007507)
Histone acetyltransferase binding
(GO:0035035)
Intracellular steroid hormone receptor signaling pathway
(GO:0030518)
In utero embryonic development
(GO:0001701)
Keratinocyte differentiation
(GO:0030216)
Lactation
(GO:0007595)
Lbd domain binding
(GO:0050693)
Lens development in camera-type eye
(GO:0002088)
Liver development
(GO:0001889)
Mammary gland epithelial cell proliferation
(GO:0033598)
Megakaryocyte development
(GO:0035855)
Monocyte differentiation
(GO:0030224)
Mrna transcription by rna polymerase ii
(GO:0042789)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of keratinocyte proliferation
(GO:0010839)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear estrogen receptor binding
(GO:0030331)
Nuclear receptor binding
(GO:0016922)
Nuclear receptor coactivator activity
(GO:0030374)
Nuclear retinoic acid receptor binding
(GO:0042974)
Nuclear thyroid hormone receptor binding
(GO:0046966)
Nuclear vitamin d receptor binding
(GO:0042809)
Peroxisome proliferator activated receptor binding
(GO:0042975)
Peroxisome proliferator activated receptor signaling pathway
(GO:0035357)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of intracellular estrogen receptor signaling pathway
(GO:0033148)
Positive regulation of keratinocyte differentiation
(GO:0045618)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription elongation by rna polymerase ii
(GO:0032968)
Promoter-specific chromatin binding
(GO:1990841)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Protein ubiquitination
(GO:0016567)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Retinal pigment epithelium development
(GO:0003406)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Thyroid hormone generation
(GO:0006590)
Thyroid hormone mediated signaling pathway
(GO:0002154)
Transcription by rna polymerase ii
(GO:0006366)
Transcription coactivator activity
(GO:0003713)
Transcription coactivator binding
(GO:0001223)
Transcription coregulator activity
(GO:0003712)
Transcription corepressor activity
(GO:0003714)
Ubiquitin protein ligase activity
(GO:0061630)
Ventricular trabecula myocardium morphogenesis
(GO:0003222)

Other Information

Proteins

Mediator of RNA polymerase II transcription subunit 1

Genular Protein ID: 2628828167

Symbol: MED1_MOUSE

Name: Mediator of RNA polymerase II transcription subunit 1

UniProtKB Accession Codes:

Q925J9 A2A526 A2A528 O88323 Q3UHV0 Q6AXD5 Q8BW37 Q8BX19 Q8VDQ7 Q925K0

Database IDs:

Citations:

PubMed ID: 9325263

Title: Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor.

PubMed ID: 9325263

DOI: 10.1074/jbc.272.41.25500

PubMed ID: 11471062

Title: High-throughput sequence identification of gene coding variants within alcohol-related QTLs.

PubMed ID: 11471062

DOI: 10.1007/s00335-001-1001-x

PubMed ID: 14500757

Title: The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development.

PubMed ID: 14500757

DOI: 10.1210/me.2003-0097

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10882104

Title: Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action.

PubMed ID: 10882104

DOI: 10.1016/s1097-2765(00)80247-6

PubMed ID: 11266503

Title: Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140.

PubMed ID: 11266503

DOI: 10.1210/mend.15.4.0624

PubMed ID: 12037571

Title: Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.

PubMed ID: 12037571

DOI: 10.1038/417563a

PubMed ID: 11867769

Title: The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro.

PubMed ID: 11867769

DOI: 10.1073/pnas.261715899

PubMed ID: 12709428

Title: The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine.

PubMed ID: 12709428

DOI: 10.1074/jbc.m300088200

PubMed ID: 14636573

Title: Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.

PubMed ID: 14636573

DOI: 10.1016/s1097-2765(03)00391-5

PubMed ID: 15150259

Title: Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.

PubMed ID: 15150259

DOI: 10.1074/jbc.m402391200

PubMed ID: 15340084

Title: Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.

PubMed ID: 15340084

DOI: 10.1128/mcb.24.18.8244-8254.2004

PubMed ID: 16137621

Title: Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220.

PubMed ID: 16137621

DOI: 10.1016/j.molcel.2005.08.008

PubMed ID: 17132730

Title: The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220.

PubMed ID: 17132730

DOI: 10.1073/pnas.0604494103

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24043798

Title: A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery.

PubMed ID: 24043798

DOI: 10.1073/pnas.1305980110

PubMed ID: 15528208

Title: Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.

PubMed ID: 15528208

DOI: 10.1074/jbc.m409302200

Sequence Information:

Length: 1575
Mass: 167141
Checksum: C3B8121A26003A22
Sequence:

MKAQGETEDS ERLSKMSSLL ERLHAKFNQN RPWSETIKLV RQVMEKRVVM SSGGHQHLVS 
CLETLQKALK VTSLPAMTDR LESIARQNGL GSHLSASGTE CYITSDMFYV EVQLDPAGQL 
CDVKVAHHGE NPVSCPELVQ QLREKNFEEF SKHLKGLVNL YNLPGDNKLK TKMYLALQSL 
EQDLSKMAIM YWKATNAAPL DKILHGSVGY LTPRSGGHLM NMKYYASPSD LLDDKTASPI 
ILHEKNVPRS LGMNASVTIE GTSAMYKLPI APLIMGSHPA DNKWTPSFSA VTSANSVDLP 
ACFFLKFPQP IPVSKAFVQK LQNCTGIPLF ETPPTYLPLY ELITQFELSK DPDPLPLNHN 
MRFYAALPGQ QHCYFLNKDA PLPDGQSLQG TLVSKITFQH PGRVPLILNM IRHQVAYNTL 
IGSCVKRTIL KEDSPGLLQF EVCPLSESRF SVSFQHPVND SLVCVVMDVQ DSTHVSCKLY 
KGLSDALICT DDFIAKVVQR CMSIPVTMRA IRRKAETIQA DTPALSLIAE TVEDMVKKNL 
PPASSPGYGM TTGNNPMSGT TTPTNTFPGG PITTLFNMSM SIKDRHESVG HGEDFSKVSQ 
NPILTSLLQI TGNGGSTIGS SPTPPHHTPP PVSSMAGNTK NHPMLMNLLK DNPAQDFSTL 
YGSSPLERQN SSSGSPRMEM CSGSNKAKKK KSSRVPPDKP KHQTEDDFQR ELFSMDVDSQ 
NPMFDVSMTA DALDTPHITP APSQCSTPPA TYPQPVSHPQ PSIQRMVRLS SSDSIGPDVT 
DILSDIAEEA SKLPSTSDDC PPIGTPVRDS SSSGHSQSAL FDSDVFQTNN NENPYTDPAD 
LIADAAGSPN SDSPTNHFFP DGVDFNPDLL NSQSQSGFGE EYFDESSQSG DNDDFKGFAS 
QALNTLGMPM LGGDNGEPKF KGSSQADTVD FSIISVAGKA LGAADLMEHH SGSQSPLLTT 
GELGKEKTQK RVKEGNGTGA SSGSGPGSDS KPGKRSRTPS NDGKSKDKPP KRKKADTEGK 
SPSHSSSNRP FTPPTSTGGS KSPGSSGRSQ TPPGVATPPI PKITIQIPKG TVMVGKPSSH 
SQYTSSGSVS SSGSKSHHSH SSSSSSLASA STSGKVKSSK SEGSSSSKLS GSMYASQGSS 
GSSQSKNSSQ TGGKPGSSPI TKHGLSSGSS STKMKPQGKP SSLMNPSISK PNISPSHSRP 
PGGSDKLASP MKPVPGTPPS SKAKSPISSG SSGSHVSGTS SSSGMKSSSG SASSGSVSQK 
TPPASNSCTP SSSSFSSSGS SMSSSQNQHG SSKGKSPSRN KKPSLTAVID KLKHGVVTSG 
PGGEDPIDSQ MGASTNSSNH PMSSKHNTSG GEFQSKREKS DKDKSKVSAS GGSVDSSKKT 
SESKNVGSTG VAKIIISKHD GGSPSIKAKV TLQKPGESGG DGLRPQIASS KNYGSPLISG 
STPKHERGSP SHSKSPAYTP QNVDSESESG SSIAERSYQN SPSSEDGIRP LPEYSTEKHK 
KHKKEKKKVR DKDRDKKKSH SMKPENWSKS PISSDPTASV TNNPILSADR PSRLSPDFMI 
GEEDDDLMDV ALIGN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Med1

Associated with

Other Information

Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. PubMed ID: 9325263

High-throughput sequence identification of gene coding variants within alcohol-related QTLs. PubMed ID: 11471062

The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development. PubMed ID: 14500757

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. PubMed ID: 10882104

Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140. PubMed ID: 11266503

Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. PubMed ID: 12037571

The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. PubMed ID: 11867769

The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. PubMed ID: 12709428

Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. PubMed ID: 14636573

Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. PubMed ID: 15150259

Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. PubMed ID: 15340084

Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220. PubMed ID: 16137621

The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. PubMed ID: 17132730

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. PubMed ID: 24043798

Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies. PubMed ID: 15528208