Genular: Defining Cellular Identity and Function

Details for: Ppard

Gene ID: 19015

Symbol: Ppard

Ensembl ID: ENSMUSG00000002250

Description: peroxisome proliferator activator receptor delta

Associated with

Carnitine metabolism
(R-MMU-200425)
Fatty acid metabolism
(R-MMU-8978868)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Nuclear receptor transcription pathway
(R-MMU-383280)
Pyruvate metabolism
(R-MMU-70268)
Pyruvate metabolism and citric acid (tca) cycle
(R-MMU-71406)
Regulation of pyruvate dehydrogenase (pdh) complex
(R-MMU-204174)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by retinoic acid
(R-MMU-5362517)
Signal transduction
(R-MMU-162582)
The citric acid (tca) cycle and respiratory electron transport
(R-MMU-1428517)
Adipose tissue development
(GO:0060612)
Anagen
(GO:0042640)
Apoptotic process
(GO:0006915)
Apoptotic signaling pathway
(GO:0097190)
Axon ensheathment
(GO:0008366)
Cell-substrate adhesion
(GO:0031589)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Cellular response to hypoxia
(GO:0071456)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to nutrient levels
(GO:0031669)
Chromatin
(GO:0000785)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Embryo implantation
(GO:0007566)
Energy homeostasis
(GO:0097009)
Enzyme activator activity
(GO:0008047)
Epidermis development
(GO:0008544)
Epithelial cell proliferation
(GO:0050673)
Fat cell proliferation
(GO:0070341)
Fatty acid beta-oxidation
(GO:0006635)
Fatty acid binding
(GO:0005504)
Fatty acid metabolic process
(GO:0006631)
Fatty acid oxidation
(GO:0019395)
Fatty acid transport
(GO:0015908)
Hormone-mediated signaling pathway
(GO:0009755)
Keratinocyte migration
(GO:0051546)
Keratinocyte proliferation
(GO:0043616)
Linoleic acid binding
(GO:0070539)
Lipid binding
(GO:0008289)
Lipid metabolic process
(GO:0006629)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cholesterol storage
(GO:0010887)
Negative regulation of collagen biosynthetic process
(GO:0032966)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of mirna transcription
(GO:1902894)
Negative regulation of myoblast differentiation
(GO:0045662)
Negative regulation of smooth muscle cell migration
(GO:0014912)
Negative regulation of smooth muscle cell proliferation
(GO:0048662)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nf-kappab binding
(GO:0051059)
Nuclear receptor activity
(GO:0004879)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phospholipid biosynthetic process
(GO:0008654)
Placenta development
(GO:0001890)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epidermis development
(GO:0045684)
Positive regulation of fat cell proliferation
(GO:0070346)
Positive regulation of fatty acid metabolic process
(GO:0045923)
Positive regulation of fatty acid oxidation
(GO:0046321)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Positive regulation of myoblast proliferation
(GO:2000288)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of skeletal muscle tissue regeneration
(GO:0043415)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Prostacyclin receptor activity
(GO:0016501)
Protein binding
(GO:0005515)
Proteoglycan metabolic process
(GO:0006029)
Regulation of cell population proliferation
(GO:0042127)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of epithelial cell proliferation
(GO:0050678)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of insulin secretion
(GO:0050796)
Regulation of skeletal muscle satellite cell proliferation
(GO:0014842)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription coactivator binding
(GO:0001223)
Vasodilation
(GO:0042311)
Wound healing
(GO:0042060)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Peroxisome proliferator-activated receptor delta

Genular Protein ID: 3837979611

Symbol: PPARD_MOUSE

Name: Peroxisome proliferator-activated receptor delta

UniProtKB Accession Codes:

P35396 P37239

Database IDs:

Citations:

PubMed ID: 7836471

Title: Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors.

PubMed ID: 7836471

DOI: 10.1074/jbc.270.5.2367

PubMed ID: 8041794

Title: Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

PubMed ID: 8041794

DOI: 10.1073/pnas.91.15.7355

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8240342

Title: Identification of two mPPAR related receptors and evidence for the existence of five subfamily members.

PubMed ID: 8240342

DOI: 10.1006/bbrc.1993.2302

PubMed ID: 28683290

Title: CRY1/2 selectively repress PPARdelta and limit exercise capacity.

PubMed ID: 28683290

DOI: 10.1016/j.cmet.2017.06.002

PubMed ID: 28751364

Title: Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.

PubMed ID: 28751364

DOI: 10.1073/pnas.1704955114

PubMed ID: 35675826

Title: Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.

PubMed ID: 35675826

DOI: 10.1016/j.cmet.2022.05.005

Sequence Information:

Length: 440
Mass: 49715
Checksum: 58E0F595DD193FDA
Sequence:

MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP SSLLDQLQMG 
CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT IRMKLEYEKC DRICKIQKKN 
RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH 
IYNAYLKNFN MTKKKARSIL TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI 
SVHVFYRCQS TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD 
GLLVANGSGF VTHEFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF IAAIILCGDR 
PGLMNVPQVE AIQDTILRAL EFHLQVNHPD SQYLFPKLLQ KMADLRQLVT EHAQMMQWLK 
KTESETLLHP LLQEIYKDMY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ppard

Associated with

Other Information

Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors. PubMed ID: 7836471

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. PubMed ID: 8041794

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. PubMed ID: 8240342

CRY1/2 selectively repress PPARdelta and limit exercise capacity. PubMed ID: 28683290

Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. PubMed ID: 28751364

Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses. PubMed ID: 35675826