Genular: Defining Cellular Identity and Function

Details for: Pparg

Gene ID: 19016

Symbol: Pparg

Ensembl ID: ENSMUSG00000000440

Description: peroxisome proliferator activated receptor gamma

Associated with

Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Alpha-actinin binding
(GO:0051393)
Arachidonic acid binding
(GO:0050544)
Bmp signaling pathway
(GO:0030509)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Cellular response to insulin stimulus
(GO:0032869)
Chromatin binding
(GO:0003682)
Diet induced thermogenesis
(GO:0002024)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Dna binding domain binding
(GO:0050692)
Double-stranded dna binding
(GO:0003690)
E-box binding
(GO:0070888)
Enzyme binding
(GO:0019899)
Epithelial cell differentiation
(GO:0030855)
Fatty acid metabolic process
(GO:0006631)
Fatty acid oxidation
(GO:0019395)
Hormone-mediated signaling pathway
(GO:0009755)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Lbd domain binding
(GO:0050693)
Long-chain fatty acid transport
(GO:0015909)
Macrophage derived foam cell differentiation
(GO:0010742)
Metal ion binding
(GO:0046872)
Monocyte differentiation
(GO:0030224)
Negative regulation of acute inflammatory response
(GO:0002674)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cholesterol storage
(GO:0010887)
Negative regulation of collagen biosynthetic process
(GO:0032966)
Negative regulation of cytokine production
(GO:0001818)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Negative regulation of sequestering of triglyceride
(GO:0010891)
Negative regulation of smooth muscle cell migration
(GO:0014912)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Nuclear estrogen receptor binding
(GO:0030331)
Nuclear receptor activity
(GO:0004879)
Nuclear receptor coactivator activity
(GO:0030374)
Nuclear retinoid x receptor binding
(GO:0046965)
Nucleic acid binding
(GO:0003676)
Peptide binding
(GO:0042277)
Peroxisome proliferator activated receptor signaling pathway
(GO:0035357)
Placenta development
(GO:0001890)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of gene expression
(GO:0010628)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Protein phosphatase binding
(GO:0019903)
Protein self-association
(GO:0043621)
R-smad binding
(GO:0070412)
Regulation of blood pressure
(GO:0008217)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to dietary excess
(GO:0002021)
Response to food
(GO:0032094)
Response to light stimulus
(GO:0009416)
Response to lipid
(GO:0033993)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Signal transduction
(GO:0007165)
Stat family protein binding
(GO:0097677)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Transcription coregulator binding
(GO:0001221)
Wound healing involved in inflammatory response
(GO:0002246)
Ww domain binding
(GO:0050699)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Genular Protein ID: 1396041523

Symbol: PPARG_MOUSE

Name: Peroxisome proliferator-activated receptor gamma

UniProtKB Accession Codes:

P37238

Database IDs:

Citations:

PubMed ID: 7926726

Title: mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

PubMed ID: 7926726

DOI: 10.1101/gad.8.10.1224

PubMed ID: 8240342

Title: Identification of two mPPAR related receptors and evidence for the existence of five subfamily members.

PubMed ID: 8240342

DOI: 10.1006/bbrc.1993.2302

PubMed ID: 8262913

Title: Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.

PubMed ID: 8262913

DOI: 10.1016/s0021-9258(19)74184-2

PubMed ID: 8041794

Title: Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

PubMed ID: 8041794

DOI: 10.1073/pnas.91.15.7355

PubMed ID: 8647948

Title: Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

PubMed ID: 8647948

DOI: 10.1172/jci118703

PubMed ID: 7838715

Title: Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha.

PubMed ID: 7838715

DOI: 10.1093/nar/22.25.5628

PubMed ID: 9325263

Title: Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor.

PubMed ID: 9325263

DOI: 10.1074/jbc.272.41.25500

PubMed ID: 10788465

Title: Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR.

PubMed ID: 10788465

DOI: 10.1074/jbc.275.18.13510

PubMed ID: 15687259

Title: Hic-5 regulates an epithelial program mediated by PPARgamma.

PubMed ID: 15687259

DOI: 10.1101/gad.1240705

PubMed ID: 17595322

Title: Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis.

PubMed ID: 17595322

DOI: 10.1210/me.2006-0520

PubMed ID: 19041764

Title: Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1.

PubMed ID: 19041764

DOI: 10.1016/j.cmet.2008.10.009

PubMed ID: 18719582

Title: PRDM16 controls a brown fat/skeletal muscle switch.

PubMed ID: 18719582

DOI: 10.1038/nature07182

PubMed ID: 19037106

Title: SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma.

PubMed ID: 19037106

DOI: 10.1091/mbc.e08-06-0647

PubMed ID: 20078863

Title: The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.

PubMed ID: 20078863

DOI: 10.1186/1471-2199-11-3

PubMed ID: 21035761

Title: PER2 controls lipid metabolism by direct regulation of PPARgamma.

PubMed ID: 21035761

DOI: 10.1016/j.cmet.2010.10.005

PubMed ID: 20498072

Title: A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation.

PubMed ID: 20498072

DOI: 10.1073/pnas.1000788107

PubMed ID: 21994940

Title: Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-? (PPAR?).

PubMed ID: 21994940

DOI: 10.1074/jbc.m111.311662

PubMed ID: 22226965

Title: O-GlcNAc modification of PPARgamma reduces its transcriptional activity.

PubMed ID: 22226965

DOI: 10.1016/j.bbrc.2011.12.086

PubMed ID: 23525231

Title: THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation.

PubMed ID: 23525231

DOI: 10.1210/me.2012-1332

PubMed ID: 25519902

Title: The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor gamma requires G protein pathway suppressor 2.

PubMed ID: 25519902

DOI: 10.1074/jbc.m114.598797

PubMed ID: 27197753

Title: F-box only protein 9 is an E3 ubiquitin ligase of PPARgamma.

PubMed ID: 27197753

DOI: 10.1038/emm.2016.31

PubMed ID: 28683290

Title: CRY1/2 selectively repress PPARdelta and limit exercise capacity.

PubMed ID: 28683290

DOI: 10.1016/j.cmet.2017.06.002

Sequence Information:

Length: 505
Mass: 57598
Checksum: AB8F3F6086E2A10A
Sequence:

MGETLGDSPV DPEHGAFADA LPMSTSQEIT MVDTEMPFWP TNFGISSVDL SVMEDHSHSF 
DIKPFTTVDF SSISAPHYED IPFTRADPMV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT 
QLYNRPHEEP SNSLMAIECR VCGDKASGFH YGVHACEGCK GFFRRTIRLK LIYDRCDLNC 
RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR 
ALAKHLYDSY IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE 
QSKEVAIRIF QGCQFRSVEA VQEITEYAKN IPGFINLDLN DQVTLLKYGV HEIIYTMLAS 
LMNKDGVLIS EGQGFMTREF LKNLRKPFGD FMEPKFEFAV KFNALELDDS DLAIFIAVII 
LSGDRPGLLN VKPIEDIQDN LLQALELQLK LNHPESSQLF AKVLQKMTDL RQIVTEHVQL 
LHVIKKTETD MSLHPLLQEI YKDLY

Genular Protein ID: 1164468668

Symbol: Q6GU14_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q6GU14

Database IDs:

Citations:

PubMed ID: 12588951

Title: Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice.

PubMed ID: 12588951

DOI: 10.1194/jlr.M300002-JLR200

PubMed ID: 12837957

Title: New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice.

PubMed ID: 12837957

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 505
Mass: 57571
Checksum: BA7F33909BE2A10A
Sequence:

MGETLGDSPV DPEHGAFADA LPMSTSQEIT MVDTEMPFWP TNFGISSVDL SVMEDHSHSF 
DIKPFTTVDF SSISAPHYED IPFTRADPMV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT 
QLYNRPHEEP SNSLMAIECR VCGDKASGFH YGVHACEGCK GFFRRTIRLK LIYDRCDLNC 
RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR 
ALAKHLYDSY IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE 
QSKEVAIRIF QGCQFRSVEA VQEITEYAKN IPGFINLDLN DQVTLLKYGV HEIIYTMLAS 
LMNKDGVLIS EGQGFMTREF LKSLRKPFGD FMEPKFEFAV KFNALELDDS DLAIFIAVII 
LSGDRPGLLN VKPIEDIQDN LLQALELQLK LNHPESSQLF AKVLQKMTDL RQIVTEHVQL 
LHVIKKTETD MSLHPLLQEI YKDLY

Genular Protein ID: 814721007

Symbol: M1VPI1_MOUSE

Name: N/A

UniProtKB Accession Codes:

M1VPI1

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 23840343

Title: A Novel Splicing Variant of Peroxisome Proliferator-Activated Receptor-? (Ppar?1sv) Cooperatively Regulates Adipocyte Differentiation with Ppar?2.

PubMed ID: 23840343

Sequence Information:

Length: 475
Mass: 54485
Checksum: EC70B1A0C4197D3F
Sequence:

MVDTEMPFWP TNFGISSVDL SVMEDHSHSF DIKPFTTVDF SSISAPHYED IPFTRADPMV 
ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT QLYNRPHEEP SNSLMAIECR VCGDKASGFH 
YGVHACEGCK GFFRRTIRLK LIYDRCDLNC RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF 
GRMPQAEKEK LLAEISSDID QLNPESADLR ALAKHLYDSY IKSFPLTKAK ARAILTGKTT 
DKSPFVIYDM NSLMMGEDKI KFKHITPLQE QSKEVAIRIF QGCQFRSVEA VQEITEYAKN 
IPGFINLDLN DQVTLLKYGV HEIIYTMLAS LMNKDGVLIS EGQGFMTREF LKSLRKPFGD 
FMEPKFEFAV KFNALELDDS DLAIFIAVII LSGDRPGLLN VKPIEDIQDN LLQALELQLK 
LNHPESSQLF AKVLQKMTDL RQIVTEHVQL LHVIKKTETD MSLHPLLQEI YKDLY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pparg

Associated with

Other Information

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. PubMed ID: 7926726

Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. PubMed ID: 8240342

Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. PubMed ID: 8262913

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. PubMed ID: 8041794

Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. PubMed ID: 8647948

Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. PubMed ID: 7838715

Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. PubMed ID: 9325263

Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. PubMed ID: 10788465

Hic-5 regulates an epithelial program mediated by PPARgamma. PubMed ID: 15687259

Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis. PubMed ID: 17595322

Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1. PubMed ID: 19041764

PRDM16 controls a brown fat/skeletal muscle switch. PubMed ID: 18719582

SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. PubMed ID: 19037106

The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR. PubMed ID: 20078863

PER2 controls lipid metabolism by direct regulation of PPARgamma. PubMed ID: 21035761

A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation. PubMed ID: 20498072

Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-? (PPAR?). PubMed ID: 21994940

O-GlcNAc modification of PPARgamma reduces its transcriptional activity. PubMed ID: 22226965

THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. PubMed ID: 23525231

The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor gamma requires G protein pathway suppressor 2. PubMed ID: 25519902

F-box only protein 9 is an E3 ubiquitin ligase of PPARgamma. PubMed ID: 27197753

CRY1/2 selectively repress PPARdelta and limit exercise capacity. PubMed ID: 28683290

Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice. PubMed ID: 12588951

New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice. PubMed ID: 12837957

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A Novel Splicing Variant of Peroxisome Proliferator-Activated Receptor-? (Ppar?1sv) Cooperatively Regulates Adipocyte Differentiation with Ppar?2. PubMed ID: 23840343

Database document:

PubMed ID: 7926726

PubMed ID: 8240342

PubMed ID: 8262913

PubMed ID: 8041794

PubMed ID: 8647948

PubMed ID: 7838715

PubMed ID: 9325263

PubMed ID: 10788465

PubMed ID: 15687259

PubMed ID: 17595322

PubMed ID: 19041764

PubMed ID: 18719582

PubMed ID: 19037106

PubMed ID: 20078863

PubMed ID: 21035761

PubMed ID: 20498072

PubMed ID: 21994940

PubMed ID: 22226965

PubMed ID: 23525231

PubMed ID: 25519902

PubMed ID: 27197753

PubMed ID: 28683290

PubMed ID: 12588951

PubMed ID: 12837957

PubMed ID: 15489334

PubMed ID: 19468303

PubMed ID: 19468303

PubMed ID: 23840343