Genular: Defining Cellular Identity and Function

Details for: Ppargc1a

Gene ID: 19017

Symbol: Ppargc1a

Ensembl ID: ENSMUSG00000029167

Description: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

Associated with

Adipose tissue development
(GO:0060612)
Alpha-tubulin binding
(GO:0043014)
Apical dendrite
(GO:0097440)
Cellular response to follicle-stimulating hormone stimulus
(GO:0071372)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to thyroid hormone stimulus
(GO:0097067)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Circadian regulation of gene expression
(GO:0032922)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Dna binding
(GO:0003677)
Energy homeostasis
(GO:0097009)
Euchromatin
(GO:0000791)
Gluconeogenesis
(GO:0006094)
Lncrna binding
(GO:0106222)
Mitochondrion organization
(GO:0007005)
Negative regulation of glycolytic process
(GO:0045820)
Negative regulation of mitochondrial fission
(GO:0090258)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of smooth muscle cell migration
(GO:0014912)
Negative regulation of smooth muscle cell proliferation
(GO:0048662)
Neuronal cell body
(GO:0043025)
Neuron apoptotic process
(GO:0051402)
Nuclear estrogen receptor binding
(GO:0030331)
Nuclear receptor binding
(GO:0016922)
Nuclear receptor coactivator activity
(GO:0030374)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peroxisome proliferator activated receptor binding
(GO:0042975)
Positive regulation of atp biosynthetic process
(GO:2001171)
Positive regulation of cellular respiration
(GO:1901857)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fatty acid oxidation
(GO:0046321)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mitochondrial dna metabolic process
(GO:1901860)
Positive regulation of mitochondrion organization
(GO:0010822)
Positive regulation of muscle tissue development
(GO:1901863)
Positive regulation of podocyte apoptotic process
(GO:1904635)
Positive regulation of progesterone biosynthetic process
(GO:2000184)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of vascular associated smooth muscle cell proliferation
(GO:1904707)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Regulation of circadian rhythm
(GO:0042752)
Regulation of dna-templated transcription
(GO:0006355)
Respiratory electron transport chain
(GO:0022904)
Response to activity
(GO:0014823)
Response to dietary excess
(GO:0002021)
Response to muscle activity
(GO:0014850)
Rhythmic process
(GO:0048511)
Rna binding
(GO:0003723)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Sequence-specific dna binding
(GO:0043565)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator activity
(GO:0003712)
Transcription factor binding
(GO:0008134)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Genular Protein ID: 836509221

Symbol: PRGC1_MOUSE

Name: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

UniProtKB Accession Codes:

O70343 L0AM20 L0AN96 L0APB0 Q3UP72

Database IDs:

Citations:

PubMed ID: 9529258

Title: A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.

PubMed ID: 9529258

DOI: 10.1016/s0092-8674(00)81410-5

PubMed ID: 23217713

Title: A PGC-1alpha isoform induced by resistance training regulates skeletal muscle hypertrophy.

PubMed ID: 23217713

DOI: 10.1016/j.cell.2012.10.050

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11108270

Title: Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expression.

PubMed ID: 11108270

DOI: 10.1210/endo.141.12.7804

PubMed ID: 12754525

Title: Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.

PubMed ID: 12754525

DOI: 10.1038/nature01667

PubMed ID: 14744933

Title: Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.

PubMed ID: 14744933

DOI: 10.1101/gad.1152204

PubMed ID: 15716268

Title: SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}.

PubMed ID: 15716268

DOI: 10.1074/jbc.m501485200

PubMed ID: 15744310

Title: Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

PubMed ID: 15744310

DOI: 10.1038/nature03354

PubMed ID: 16950137

Title: Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.

PubMed ID: 16950137

DOI: 10.1016/j.cmet.2006.08.005

PubMed ID: 17618855

Title: Transcriptional control of brown fat determination by PRDM16.

PubMed ID: 17618855

DOI: 10.1016/j.cmet.2007.06.001

PubMed ID: 17609368

Title: AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.

PubMed ID: 17609368

DOI: 10.1073/pnas.0705070104

PubMed ID: 17476214

Title: Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism.

PubMed ID: 17476214

DOI: 10.1038/nature05767

PubMed ID: 18483224

Title: Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.

PubMed ID: 18483224

DOI: 10.1101/gad.1666108

PubMed ID: 20074525

Title: Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis.

PubMed ID: 20074525

DOI: 10.1016/j.cmet.2009.11.006

PubMed ID: 22886304

Title: A metabolic prosurvival role for PML in breast cancer.

PubMed ID: 22886304

DOI: 10.1172/jci62129

PubMed ID: 22237023

Title: A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.

PubMed ID: 22237023

DOI: 10.1038/nature10777

Sequence Information:

Length: 797
Mass: 90588
Checksum: AE73EE2B3A622B05
Sequence:

MAWDMCSQDS VWSDIECAAL VGEDQPLCPD LPELDLSELD VNDLDTDSFL GGLKWCSDQS 
EIISNQYNNE PANIFEKIDE ENEANLLAVL TETLDSLPVD EDGLPSFDAL TDGAVTTDNE 
ASPSSMPDGT PPPQEAEEPS LLKKLLLAPA NTQLSYNECS GLSTQNHAAN HTHRIRTNPA 
IVKTENSWSN KAKSICQQQK PQRRPCSELL KYLTTNDDPP HTKPTENRNS SRDKCASKKK 
SHTQPQSQHA QAKPTTLSLP LTPESPNDPK GSPFENKTIE RTLSVELSGT AGLTPPTTPP 
HKANQDNPFK ASPKLKPSCK TVVPPPTKRA RYSECSGTQG SHSTKKGPEQ SELYAQLSKS 
SGLSRGHEER KTKRPSLRLF GDHDYCQSLN SKTDILINIS QELQDSRQLD FKDASCDWQG 
HICSSTDSGQ CYLRETLEAS KQVSPCSTRK QLQDQEIRAE LNKHFGHPCQ AVFDDKSDKT 
SELRDGDFSN EQFSKLPVFI NSGLAMDGLF DDSEDESDKL SYPWDGTQPY SLFDVSPSCS 
SFNSPCRDSV SPPKSLFSQR PQRMRSRSRS FSRHRSCSRS PYSRSRSRSP GSRSSSRSCY 
YYESSHYRHR THRNSPLYVR SRSRSPYSRR PRYDSYEAYE HERLKRDEYR KEHEKRESER 
AKQRERQKQK AIEERRVIYV GKIRPDTTRT ELRDRFEVFG EIEECTVNLR DDGDSYGFIT 
YRYTCDAFAA LENGYTLRRS NETDFELYFC GRKQFFKSNY ADLDTNSDDF DPASTKSKYD 
SLDFDSLLKE AQRSLRR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ppargc1a

Associated with

Other Information

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. PubMed ID: 9529258

A PGC-1alpha isoform induced by resistance training regulates skeletal muscle hypertrophy. PubMed ID: 23217713

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expression. PubMed ID: 11108270

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. PubMed ID: 12754525

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. PubMed ID: 14744933

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. PubMed ID: 15716268

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. PubMed ID: 15744310

Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. PubMed ID: 16950137

Transcriptional control of brown fat determination by PRDM16. PubMed ID: 17618855

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. PubMed ID: 17609368

Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. PubMed ID: 17476214

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. PubMed ID: 18483224

Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. PubMed ID: 20074525

A metabolic prosurvival role for PML in breast cancer. PubMed ID: 22886304

A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. PubMed ID: 22237023