Genular: Defining Cellular Identity and Function

Details for: Ppm1a

Gene ID: 19042

Symbol: Ppm1a

Ensembl ID: ENSMUSG00000021096

Description: protein phosphatase 1A, magnesium dependent, alpha isoform

Associated with

Downregulation of smad2/3:smad4 transcriptional activity
(R-MMU-2173795)
Energy dependent regulation of mtor by lkb1-ampk
(R-MMU-380972)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Mtor signalling
(R-MMU-165159)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-MMU-2173793)
Calmodulin-dependent protein phosphatase activity
(GO:0033192)
Cation binding
(GO:0043169)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dephosphorylation
(GO:0016311)
Hydrolase activity
(GO:0016787)
Magnesium ion binding
(GO:0000287)
Manganese ion binding
(GO:0030145)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Myosin phosphatase activity
(GO:0017018)
N-terminal protein myristoylation
(GO:0006499)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of non-canonical nf-kappab signal transduction
(GO:1901223)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Neuron projection
(GO:0043005)
Nucleus
(GO:0005634)
Peptidyl-threonine dephosphorylation
(GO:0035970)
Phosphoprotein phosphatase activity
(GO:0004721)
Plasma membrane
(GO:0005886)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of protein export from nucleus
(GO:0046827)
Protein dephosphorylation
(GO:0006470)
Protein export from nucleus
(GO:0006611)
Protein serine/threonine phosphatase activity
(GO:0004722)
R-smad binding
(GO:0070412)
Transmembrane transporter binding
(GO:0044325)

Other Information

Proteins

Protein phosphatase 1A
Q9EQE3_MOUSE

Genular Protein ID: 786193397

Symbol: PPM1A_MOUSE

Name: Protein phosphatase 1A

UniProtKB Accession Codes:

P49443

Database IDs:

Citations:

PubMed ID: 8056349

Title: The cDNA sequence encoding mouse Mg2+ -dependent protein phosphatase alpha.

PubMed ID: 8056349

DOI: 10.1016/0378-1119(94)90026-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22781750

Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.

PubMed ID: 22781750

DOI: 10.1016/j.cellsig.2012.07.003

PubMed ID: 23088624

Title: N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells.

PubMed ID: 23088624

DOI: 10.1042/bj20121201

Sequence Information:

Length: 382
Mass: 42433
Checksum: DC206610E1583870
Sequence:

MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ETWSFFAVYD 
GHAGSQVAKY CCEHLLDHIT NNQDFRGSAG APSVENVKNG IRTGFLEIDE HMRVMSEKKH 
GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG 
SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG 
IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILIC FPSAPKVSAE 
AVKKEAELDK YLESRVEEII KKQVEGVPDL VHVMRTLASE NIPSLPPGGE LASKRNVIEA 
VYNRLNPYKN DDTDSASTDD MW

Genular Protein ID: 3604149662

Symbol: Q9EQE3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9EQE3

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 326
Mass: 36111
Checksum: 19AA1994931A823B
Sequence:

MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ETWSFFAVYD 
GHAGSQVAKY CCEHLLDHIT NNQDFRGSAG APSVENVKNG IRTGFLEIDE HMRVMSEKKH 
GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG 
SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG 
IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILIC FPSAPKVSAE 
AVKKEAELDK YLESRVEGGS LTKINK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ppm1a

Associated with

Other Information

The cDNA sequence encoding mouse Mg2+ -dependent protein phosphatase alpha. PubMed ID: 8056349

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway. PubMed ID: 22781750

N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells. PubMed ID: 23088624

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073