Genular: Defining Cellular Identity and Function

Details for: Ppp1ca

Gene ID: 19045

Symbol: Ppp1ca

Ensembl ID: ENSMUSG00000040385

Description: protein phosphatase 1 catalytic subunit alpha

Associated with

Darpp-32 events
(R-MMU-180024)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Opioid signalling
(R-MMU-111885)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Adherens junction
(GO:0005912)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Cadherin binding involved in cell-cell adhesion
(GO:0098641)
Carbohydrate metabolic process
(GO:0005975)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Chromosome, telomeric region
(GO:0000781)
Circadian regulation of gene expression
(GO:0032922)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendritic spine
(GO:0043197)
Dephosphorylation
(GO:0016311)
Entrainment of circadian clock by photoperiod
(GO:0043153)
Glutamatergic synapse
(GO:0098978)
Glycogen granule
(GO:0042587)
Glycogen metabolic process
(GO:0005977)
Hydrolase activity
(GO:0016787)
Lung development
(GO:0030324)
Metal ion binding
(GO:0046872)
Myosin phosphatase activity
(GO:0017018)
Neuronal cell body
(GO:0043025)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perikaryon
(GO:0043204)
Phosphatase activity
(GO:0016791)
Phosphoprotein phosphatase activity
(GO:0004721)
Plasma membrane
(GO:0005886)
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001241)
Postsynapse
(GO:0098794)
Presynapse
(GO:0098793)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein phosphatase 1 binding
(GO:0008157)
Protein phosphatase type 1 complex
(GO:0000164)
Protein serine/threonine phosphatase activity
(GO:0004722)
Ptw/pp1 phosphatase complex
(GO:0072357)
Regulation of circadian rhythm
(GO:0042752)
Regulation of glycogen biosynthetic process
(GO:0005979)
Regulation of glycogen catabolic process
(GO:0005981)
Regulation of translation
(GO:0006417)
Response to lead ion
(GO:0010288)
Rhythmic process
(GO:0048511)
Ribonucleoprotein complex binding
(GO:0043021)

Other Information

Proteins

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Genular Protein ID: 2361307338

Symbol: PP1A_MOUSE

Name: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

UniProtKB Accession Codes:

P62137 P08129 P20653 P22802 Q3U7G7 Q9Z1G2

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8077208

Title: Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain.

PubMed ID: 8077208

DOI: 10.1016/s0021-9258(17)31686-1

PubMed ID: 14638860

Title: Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells.

PubMed ID: 14638860

DOI: 10.1083/jcb.200308075

PubMed ID: 16835242

Title: Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.

PubMed ID: 16835242

DOI: 10.1074/jbc.m513556200

PubMed ID: 17609112

Title: Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression.

PubMed ID: 17609112

DOI: 10.1016/j.devcel.2007.04.018

PubMed ID: 18160256

Title: A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB.

PubMed ID: 18160256

DOI: 10.1016/j.cellsig.2007.11.004

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21712997

Title: Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.

PubMed ID: 21712997

DOI: 10.1371/journal.pone.0021325

PubMed ID: 21930935

Title: The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.

PubMed ID: 21930935

DOI: 10.1073/pnas.1107178108

PubMed ID: 22215812

Title: Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity.

PubMed ID: 22215812

DOI: 10.1101/gad.179283.111

PubMed ID: 24156551

Title: KCTD20, a relative of BTBD10, is a positive regulator of Akt.

PubMed ID: 24156551

DOI: 10.1186/1471-2091-14-27

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

Sequence Information:

Length: 330
Mass: 37540
Checksum: 8FBFD158A52282E0
Sequence:

MSDSEKLNLD SIIGRLLEVQ GSRPGKNVQL TENEIRGLCL KSREIFLSQP ILLELEAPLK 
ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIRYPENFFL 
LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL 
QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVQGWGEND RGVSFTFGAE VVAKFLHKHD 
LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAD 
KNKGKYGQFS GLNPGGRPIT PPRNSAKAKK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ppp1ca

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. PubMed ID: 8077208

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. PubMed ID: 14638860

Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress. PubMed ID: 16835242

Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression. PubMed ID: 17609112

A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. PubMed ID: 18160256

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. PubMed ID: 21712997

The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. PubMed ID: 21930935

Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity. PubMed ID: 22215812

KCTD20, a relative of BTBD10, is a positive regulator of Akt. PubMed ID: 24156551

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337