Genular: Defining Cellular Identity and Function

Details for: Ppp2ca

Gene ID: 19052

Symbol: Ppp2ca

Ensembl ID: ENSMUSG00000020349

Description: protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform

Associated with

Adaptive immune system
(R-MMU-1280218)
Amplification of signal from the kinetochores
(R-MMU-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-MMU-141444)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Beta-catenin phosphorylation cascade
(R-MMU-196299)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Costimulation by the cd28 family
(R-MMU-388841)
Ctla4 inhibitory signaling
(R-MMU-389513)
Cyclin a/b1/b2 associated events during g2/m transition
(R-MMU-69273)
Cyclin d associated events in g1
(R-MMU-69231)
Cytokine signaling in immune system
(R-MMU-1280215)
Darpp-32 events
(R-MMU-180024)
Degradation of beta-catenin by the destruction complex
(R-MMU-195253)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-MMU-4641262)
E2f mediated regulation of dna replication
(R-MMU-113510)
Eml4 and nudc in mitotic spindle formation
(R-MMU-9648025)
G1 phase
(R-MMU-69236)
G1/s transition
(R-MMU-69206)
G2/m transition
(R-MMU-69275)
G alpha (i) signalling events
(R-MMU-418594)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Gpcr downstream signalling
(R-MMU-388396)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Inhibition of replication initiation of damaged dna by rb1/e2f1
(R-MMU-113501)
Innate immune system
(R-MMU-168249)
Interferon signaling
(R-MMU-913531)
Interleukin-17 signaling
(R-MMU-448424)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism of rna
(R-MMU-8953854)
Mitotic anaphase
(R-MMU-68882)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prometaphase
(R-MMU-68877)
Mitotic spindle checkpoint
(R-MMU-69618)
M phase
(R-MMU-68886)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Negative regulation of fgfr1 signaling
(R-MMU-5654726)
Negative regulation of fgfr2 signaling
(R-MMU-5654727)
Negative regulation of fgfr3 signaling
(R-MMU-5654732)
Negative regulation of fgfr4 signaling
(R-MMU-5654733)
Negative regulation of mapk pathway
(R-MMU-5675221)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Nonsense-mediated decay (nmd)
(R-MMU-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-MMU-975957)
Nuclear envelope (ne) reassembly
(R-MMU-2995410)
Nuclear events (kinase and transcription factor activation)
(R-MMU-198725)
Opioid signalling
(R-MMU-111885)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Pkr-mediated signaling
(R-MMU-9833482)
Platelet homeostasis
(R-MMU-418346)
Platelet sensitization by ldl
(R-MMU-432142)
Raf/map kinase cascade
(R-MMU-5673001)
Raf activation
(R-MMU-5673000)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 expression and degradation
(R-MMU-6806003)
Resolution of sister chromatid cohesion
(R-MMU-2500257)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Rna polymerase ii transcription
(R-MMU-73857)
Separation of sister chromatids
(R-MMU-2467813)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by fgfr3
(R-MMU-5654741)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by gpcr
(R-MMU-372790)
Signaling by interleukins
(R-MMU-449147)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Spry regulation of fgf signaling
(R-MMU-1295596)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Transcriptional regulation by tp53
(R-MMU-3700989)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)

Other Information

Proteins

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Genular Protein ID: 2567503937

Symbol: PP2AA_MOUSE

Name: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

UniProtKB Accession Codes:

P63330 O88591 P13353 Q5SNY5

Database IDs:

Citations:

PubMed ID: 9920888

Title: Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.

PubMed ID: 9920888

DOI: 10.1074/jbc.274.6.3439

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7510677

Title: Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.

PubMed ID: 7510677

DOI: 10.1016/s0021-9258(17)37144-2

PubMed ID: 10441131

Title: Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.

PubMed ID: 10441131

DOI: 10.1021/bi990902g

PubMed ID: 16764867

Title: Interaction of nucleoredoxin with protein phosphatase 2A.

PubMed ID: 16764867

DOI: 10.1016/j.febslet.2006.04.101

PubMed ID: 16258073

Title: A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.

PubMed ID: 16258073

DOI: 10.1124/mol.105.018275

PubMed ID: 18160256

Title: A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB.

PubMed ID: 18160256

DOI: 10.1016/j.cellsig.2007.11.004

PubMed ID: 18084284

Title: Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells.

PubMed ID: 18084284

DOI: 10.1038/ncb1667

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24156551

Title: KCTD20, a relative of BTBD10, is a positive regulator of Akt.

PubMed ID: 24156551

DOI: 10.1186/1471-2091-14-27

PubMed ID: 25546391

Title: The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development.

PubMed ID: 25546391

DOI: 10.1371/journal.pone.0116150

PubMed ID: 25438055

Title: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.

PubMed ID: 25438055

DOI: 10.1038/ncb3072

PubMed ID: 26974206

Title: Phosphatase PP2A is requisite for the function of regulatory T cells.

PubMed ID: 26974206

DOI: 10.1038/ni.3390

PubMed ID: 28465465

Title: NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain.

PubMed ID: 28465465

DOI: 10.1084/jem.20160933

PubMed ID: 30611118

Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

PubMed ID: 30611118

DOI: 10.1016/j.isci.2018.12.012

PubMed ID: 33505023

Title: AIM2 in regulatory T cells restrains autoimmune diseases.

PubMed ID: 33505023

DOI: 10.1038/s41586-021-03231-w

Sequence Information:

Length: 309
Mass: 35608
Checksum: 8DC11276E6DF9E33
Sequence:

MDEKLFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 
QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 
RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 
RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 
HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 
TRRTPDYFL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ppp2ca

Associated with

Other Information

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. PubMed ID: 9920888

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts. PubMed ID: 7510677

Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2. PubMed ID: 10441131

Interaction of nucleoredoxin with protein phosphatase 2A. PubMed ID: 16764867

A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A. PubMed ID: 16258073

A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. PubMed ID: 18160256

Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells. PubMed ID: 18084284

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

KCTD20, a relative of BTBD10, is a positive regulator of Akt. PubMed ID: 24156551

The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development. PubMed ID: 25546391

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. PubMed ID: 25438055

Phosphatase PP2A is requisite for the function of regulatory T cells. PubMed ID: 26974206

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain. PubMed ID: 28465465

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. PubMed ID: 30611118

AIM2 in regulatory T cells restrains autoimmune diseases. PubMed ID: 33505023