Genular: Defining Cellular Identity and Function

Details for: Ppp3ca

Gene ID: 19055

Symbol: Ppp3ca

Ensembl ID: ENSMUSG00000028161

Description: protein phosphatase 3, catalytic subunit, alpha isoform

Associated with

Adaptive immune system
(R-MMU-1280218)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Ca2+ pathway
(R-MMU-4086398)
Calcineurin activates nfat
(R-MMU-2025928)
Clec7a (dectin-1) induces nfat activation
(R-MMU-5607763)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated ca+2 mobilization
(R-MMU-2871809)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Atpase binding
(GO:0051117)
Calcineurin-mediated signaling
(GO:0097720)
Calcineurin-nfat signaling cascade
(GO:0033173)
Calcineurin complex
(GO:0005955)
Calcium-dependent protein serine/threonine phosphatase activity
(GO:0004723)
Calcium-mediated signaling
(GO:0019722)
Calcium ion transport
(GO:0006816)
Calmodulin-dependent protein phosphatase activity
(GO:0033192)
Calmodulin binding
(GO:0005516)
Cardiac muscle hypertrophy in response to stress
(GO:0014898)
Cellular response to glucose stimulus
(GO:0071333)
Cyclosporin a binding
(GO:0016018)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite morphogenesis
(GO:0048813)
Dephosphorylation
(GO:0016311)
Enzyme binding
(GO:0019899)
Epidermis development
(GO:0008544)
Excitatory postsynaptic potential
(GO:0060079)
G1/s transition of mitotic cell cycle
(GO:0000082)
Hydrolase activity
(GO:0016787)
Keratinocyte differentiation
(GO:0030216)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Modulation of chemical synaptic transmission
(GO:0050804)
Multicellular organismal response to stress
(GO:0033555)
Myosin phosphatase activity
(GO:0017018)
Negative regulation of angiotensin-activated signaling pathway
(GO:0110062)
Negative regulation of calcium ion import across plasma membrane
(GO:1905949)
Negative regulation of chromatin binding
(GO:0035562)
Negative regulation of dendrite morphogenesis
(GO:0050774)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of signaling
(GO:0023057)
Nucleus
(GO:0005634)
Peptidyl-serine dephosphorylation
(GO:0070262)
Phosphoprotein phosphatase activity
(GO:0004721)
Plasma membrane
(GO:0005886)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of calcineurin-nfat signaling cascade
(GO:0070886)
Positive regulation of calcium ion import across plasma membrane
(GO:1905665)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cardiac muscle hypertrophy in response to stress
(GO:1903244)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of connective tissue replacement
(GO:1905205)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of endocytosis
(GO:0045807)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glomerulus development
(GO:0090193)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of saliva secretion
(GO:0046878)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Postsynaptic modulation of chemical synaptic transmission
(GO:0099170)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein dimerization activity
(GO:0046983)
Protein import into nucleus
(GO:0006606)
Protein serine/threonine phosphatase activity
(GO:0004722)
Regulation of cell proliferation involved in kidney morphogenesis
(GO:0061006)
Renal filtration
(GO:0097205)
Response to calcium ion
(GO:0051592)
Skeletal muscle fiber development
(GO:0048741)
Transition between fast and slow fiber
(GO:0014883)

Other Information

Proteins

CAM-PRP catalytic subunit

Genular Protein ID: 735070695

Symbol: PP2BA_MOUSE

Name: CAM-PRP catalytic subunit

UniProtKB Accession Codes:

P63328 B2RRX2 P12816 P20652 Q3UCU1 Q64135

Database IDs:

Citations:

PubMed ID: 2162844

Title: Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.

PubMed ID: 2162844

DOI: 10.1016/s0021-9258(19)38593-x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8077208

Title: Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain.

PubMed ID: 8077208

DOI: 10.1016/s0021-9258(17)31686-1

PubMed ID: 2848250

Title: Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin.

PubMed ID: 2848250

DOI: 10.1073/pnas.85.23.8983

PubMed ID: 7791792

Title: Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells.

PubMed ID: 7791792

DOI: 10.1128/mcb.15.7.3857

PubMed ID: 8627154

Title: T cell responses in calcineurin A alpha-deficient mice.

PubMed ID: 8627154

DOI: 10.1084/jem.183.2.413

PubMed ID: 10200317

Title: A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus.

PubMed ID: 10200317

DOI: 10.1073/pnas.96.8.4650

PubMed ID: 11114196

Title: Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.

PubMed ID: 11114196

DOI: 10.1073/pnas.260501097

PubMed ID: 12809556

Title: Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.

PubMed ID: 12809556

DOI: 10.1042/bj20030267

PubMed ID: 12773574

Title: Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.

PubMed ID: 12773574

DOI: 10.1128/mcb.23.12.4331-4343.2003

PubMed ID: 15509543

Title: Calcineurin A-alpha but not A-beta is required for normal kidney development and function.

PubMed ID: 15509543

DOI: 10.1016/s0002-9440(10)63430-x

PubMed ID: 16286645

Title: Calcineurin regulates bone formation by the osteoblast.

PubMed ID: 16286645

DOI: 10.1073/pnas.0508480102

PubMed ID: 16800626

Title: Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease.

PubMed ID: 16800626

DOI: 10.1021/bi060474w

PubMed ID: 16735444

Title: Loss of calcineurin Aalpha results in altered trafficking of AQP2 and in nephrogenic diabetes insipidus.

PubMed ID: 16735444

DOI: 10.1242/jcs.02971

PubMed ID: 16968888

Title: Evidence that calcineurin is required for the genesis of bone-resorbing osteoclasts.

PubMed ID: 16968888

DOI: 10.1152/ajprenal.00415.2005

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19626032

Title: Loss of calcineurin Aalpha alters keratinocyte survival and differentiation.

PubMed ID: 19626032

DOI: 10.1038/jid.2009.222

PubMed ID: 20639889

Title: CIB1 is a regulator of pathological cardiac hypertrophy.

PubMed ID: 20639889

DOI: 10.1038/nm.2181

PubMed ID: 21435446

Title: Rescue of calcineurin Aalpha(-/-) mice reveals a novel role for the alpha isoform in the salivary gland.

PubMed ID: 21435446

DOI: 10.1016/j.ajpath.2010.12.054

PubMed ID: 21427212

Title: Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration.

PubMed ID: 21427212

DOI: 10.1096/fj.10-169219

PubMed ID: 26029823

Title: Catalytic subunits of the phosphatase calcineurin interact with NF-kappaB-inducing kinase (NIK) and attenuate NIK-dependent gene expression.

PubMed ID: 26029823

DOI: 10.1038/srep10758

PubMed ID: 30611118

Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

PubMed ID: 30611118

DOI: 10.1016/j.isci.2018.12.012

PubMed ID: 31696965

Title: Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.

PubMed ID: 31696965

DOI: 10.15252/embj.2018101409

PubMed ID: 26794871

Title: Cooperative autoinhibition and multi-level activation mechanisms of calcineurin.

PubMed ID: 26794871

DOI: 10.1038/cr.2016.14

Sequence Information:

Length: 521
Mass: 58644
Checksum: 16530C27DDBF1F05
Sequence:

MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV 
ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV 
DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD 
AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG 
NEKTQEHFTH NTVRGCSYFY SYPAVCDFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP 
SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK 
VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV 
LTLKGLTPTG MLPSGVLSGG KQTLQSATVE AIEADEAIKG FSPQHKITSF EEAKGLDRIN 
ERMPPRRDAM PSDANLNSIN KALASETNGT DSNGSNSSNI Q

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ppp3ca

Associated with

Other Information

Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods. PubMed ID: 2162844

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. PubMed ID: 8077208

Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin. PubMed ID: 2848250

Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells. PubMed ID: 7791792

T cell responses in calcineurin A alpha-deficient mice. PubMed ID: 8627154

A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus. PubMed ID: 10200317

Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. PubMed ID: 11114196

Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. PubMed ID: 12809556

Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice. PubMed ID: 12773574

Calcineurin A-alpha but not A-beta is required for normal kidney development and function. PubMed ID: 15509543

Calcineurin regulates bone formation by the osteoblast. PubMed ID: 16286645

Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease. PubMed ID: 16800626

Loss of calcineurin Aalpha results in altered trafficking of AQP2 and in nephrogenic diabetes insipidus. PubMed ID: 16735444

Evidence that calcineurin is required for the genesis of bone-resorbing osteoclasts. PubMed ID: 16968888

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Loss of calcineurin Aalpha alters keratinocyte survival and differentiation. PubMed ID: 19626032

CIB1 is a regulator of pathological cardiac hypertrophy. PubMed ID: 20639889

Rescue of calcineurin Aalpha(-/-) mice reveals a novel role for the alpha isoform in the salivary gland. PubMed ID: 21435446

Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration. PubMed ID: 21427212

Catalytic subunits of the phosphatase calcineurin interact with NF-kappaB-inducing kinase (NIK) and attenuate NIK-dependent gene expression. PubMed ID: 26029823

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. PubMed ID: 30611118

Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation. PubMed ID: 31696965

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin. PubMed ID: 26794871